Effect of Acacia Honey on Serum Uric Acid Level and Liver Injury in Rats
Objective Honey is generally considered to be a natural product with rich nutritional value. However, the fructose contained in honey is harmful to the liver. This study aims to observe the effect of acacia honey (AH) on serum uric acid and liver injury in potassium oxonate model rats after drinking...
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| Veröffentlicht in: | Natural product communications 2024-12, Vol.19 (12) |
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| container_title | Natural product communications |
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| creator | Xu, Xiuhe Zhang, Peiyan Cui, Qingke He, Xiaoli Pan, Lizhu Zhou, Zhuojun Li, Jiayue Wang, Caixia Yang, Xiaojuan Zhu, Guiqi |
| description | Objective
Honey is generally considered to be a natural product with rich nutritional value. However, the fructose contained in honey is harmful to the liver. This study aims to observe the effect of acacia honey (AH) on serum uric acid and liver injury in potassium oxonate model rats after drinking AH aqueous solution.
Materials and methods
Sixty male Sprague-Dawley (SD) rats were selected and randomly divided into control group (CON group), potassium oxonate model group (OA model group), 10% fructose group (10%F group) and different concentration AH groups (25%, 12.5% and 6.25% AH groups). 100 mg/kg OA solution combined with fructose solution or AH solution was administered to gavage model rats. After the 4 weeks test, blood and liver tissues were collected, serum uric acid content, biochemical indexes, activities of alanine transaminase and alanine transaminase were determined, and liver histological sections were observed.
Results
AH can significantly increase serum uric acid level, liver weight and liver to body weight ratio (p |
| doi_str_mv | 10.1177/1934578X241302566 |
| format | Article |
| fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1177_1934578X241302566</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1934578X241302566</sage_id><sourcerecordid>10.1177_1934578X241302566</sourcerecordid><originalsourceid>FETCH-LOGICAL-c209t-30cabc0e0d6338cb6fff9b6c7ec8a5776fee6d56251bd89762950727dfc81fa33</originalsourceid><addsrcrecordid>eNp9kN1Kw0AQhRdRsNQ-gHf7Aqn7k_27LKWaQkBQC96FzWZWEtpEdpNC3t4t9U5wbubAmW84HIQeKVlTqtQTNTwXSn-ynHLChJQ3aEGFEJnJlbhNOvnZ5eAerWLsSBqtc5KbBSp23oMb8eDxxlnXWlwMPcx46PE7hOmED6F1yWobXMIZjtj2SbVnCHjfd1OYcdvjNzvGB3Tn7THC6ncv0eF597EtsvL1Zb_dlJljxIwZJ87WjgBpJOfa1dJ7b2rpFDhthVLSA8hGSCZo3WijJDOCKKYa7zT1lvMlote_LgwxBvDVd2hPNswVJdWljepPG4lZX5lov6Dqhin0KeI_wA_8z15K</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effect of Acacia Honey on Serum Uric Acid Level and Liver Injury in Rats</title><source>DOAJ Directory of Open Access Journals</source><source>Sage Journals GOLD Open Access 2024</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Xu, Xiuhe ; Zhang, Peiyan ; Cui, Qingke ; He, Xiaoli ; Pan, Lizhu ; Zhou, Zhuojun ; Li, Jiayue ; Wang, Caixia ; Yang, Xiaojuan ; Zhu, Guiqi</creator><creatorcontrib>Xu, Xiuhe ; Zhang, Peiyan ; Cui, Qingke ; He, Xiaoli ; Pan, Lizhu ; Zhou, Zhuojun ; Li, Jiayue ; Wang, Caixia ; Yang, Xiaojuan ; Zhu, Guiqi</creatorcontrib><description>Objective
Honey is generally considered to be a natural product with rich nutritional value. However, the fructose contained in honey is harmful to the liver. This study aims to observe the effect of acacia honey (AH) on serum uric acid and liver injury in potassium oxonate model rats after drinking AH aqueous solution.
Materials and methods
Sixty male Sprague-Dawley (SD) rats were selected and randomly divided into control group (CON group), potassium oxonate model group (OA model group), 10% fructose group (10%F group) and different concentration AH groups (25%, 12.5% and 6.25% AH groups). 100 mg/kg OA solution combined with fructose solution or AH solution was administered to gavage model rats. After the 4 weeks test, blood and liver tissues were collected, serum uric acid content, biochemical indexes, activities of alanine transaminase and alanine transaminase were determined, and liver histological sections were observed.
Results
AH can significantly increase serum uric acid level, liver weight and liver to body weight ratio (p < 0.05). The levels of serum triglyceride (TG), free fatty acid (FFA), and high-density fatty acid cholesterol (HDL-C) were elevated in 25% and 12.5% AH groups compared with CON group or OA model group (p < 0.05), but serum levels of TG, FFA, HDL-C, total cholesterol (T-CHO) and low density lipoprotein cholesterol (LDL-C) were significantly increased in 6.25%AH group (p < 0.05).
Conclusion
AH can cause fatty liver disease in all rats in a dose dependent manner. In the dose range of the present study, AH can induce hyperuricemia, hypertriglyceridemia and fatty liver disease.</description><identifier>ISSN: 1934-578X</identifier><identifier>EISSN: 1555-9475</identifier><identifier>DOI: 10.1177/1934578X241302566</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><ispartof>Natural product communications, 2024-12, Vol.19 (12)</ispartof><rights>The Author(s) 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c209t-30cabc0e0d6338cb6fff9b6c7ec8a5776fee6d56251bd89762950727dfc81fa33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1934578X241302566$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1934578X241302566$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,21945,27830,27901,27902,44921,45309</link.rule.ids></links><search><creatorcontrib>Xu, Xiuhe</creatorcontrib><creatorcontrib>Zhang, Peiyan</creatorcontrib><creatorcontrib>Cui, Qingke</creatorcontrib><creatorcontrib>He, Xiaoli</creatorcontrib><creatorcontrib>Pan, Lizhu</creatorcontrib><creatorcontrib>Zhou, Zhuojun</creatorcontrib><creatorcontrib>Li, Jiayue</creatorcontrib><creatorcontrib>Wang, Caixia</creatorcontrib><creatorcontrib>Yang, Xiaojuan</creatorcontrib><creatorcontrib>Zhu, Guiqi</creatorcontrib><title>Effect of Acacia Honey on Serum Uric Acid Level and Liver Injury in Rats</title><title>Natural product communications</title><description>Objective
Honey is generally considered to be a natural product with rich nutritional value. However, the fructose contained in honey is harmful to the liver. This study aims to observe the effect of acacia honey (AH) on serum uric acid and liver injury in potassium oxonate model rats after drinking AH aqueous solution.
Materials and methods
Sixty male Sprague-Dawley (SD) rats were selected and randomly divided into control group (CON group), potassium oxonate model group (OA model group), 10% fructose group (10%F group) and different concentration AH groups (25%, 12.5% and 6.25% AH groups). 100 mg/kg OA solution combined with fructose solution or AH solution was administered to gavage model rats. After the 4 weeks test, blood and liver tissues were collected, serum uric acid content, biochemical indexes, activities of alanine transaminase and alanine transaminase were determined, and liver histological sections were observed.
Results
AH can significantly increase serum uric acid level, liver weight and liver to body weight ratio (p < 0.05). The levels of serum triglyceride (TG), free fatty acid (FFA), and high-density fatty acid cholesterol (HDL-C) were elevated in 25% and 12.5% AH groups compared with CON group or OA model group (p < 0.05), but serum levels of TG, FFA, HDL-C, total cholesterol (T-CHO) and low density lipoprotein cholesterol (LDL-C) were significantly increased in 6.25%AH group (p < 0.05).
Conclusion
AH can cause fatty liver disease in all rats in a dose dependent manner. In the dose range of the present study, AH can induce hyperuricemia, hypertriglyceridemia and fatty liver disease.</description><issn>1934-578X</issn><issn>1555-9475</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><recordid>eNp9kN1Kw0AQhRdRsNQ-gHf7Aqn7k_27LKWaQkBQC96FzWZWEtpEdpNC3t4t9U5wbubAmW84HIQeKVlTqtQTNTwXSn-ynHLChJQ3aEGFEJnJlbhNOvnZ5eAerWLsSBqtc5KbBSp23oMb8eDxxlnXWlwMPcx46PE7hOmED6F1yWobXMIZjtj2SbVnCHjfd1OYcdvjNzvGB3Tn7THC6ncv0eF597EtsvL1Zb_dlJljxIwZJ87WjgBpJOfa1dJ7b2rpFDhthVLSA8hGSCZo3WijJDOCKKYa7zT1lvMlote_LgwxBvDVd2hPNswVJdWljepPG4lZX5lov6Dqhin0KeI_wA_8z15K</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Xu, Xiuhe</creator><creator>Zhang, Peiyan</creator><creator>Cui, Qingke</creator><creator>He, Xiaoli</creator><creator>Pan, Lizhu</creator><creator>Zhou, Zhuojun</creator><creator>Li, Jiayue</creator><creator>Wang, Caixia</creator><creator>Yang, Xiaojuan</creator><creator>Zhu, Guiqi</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>202412</creationdate><title>Effect of Acacia Honey on Serum Uric Acid Level and Liver Injury in Rats</title><author>Xu, Xiuhe ; Zhang, Peiyan ; Cui, Qingke ; He, Xiaoli ; Pan, Lizhu ; Zhou, Zhuojun ; Li, Jiayue ; Wang, Caixia ; Yang, Xiaojuan ; Zhu, Guiqi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c209t-30cabc0e0d6338cb6fff9b6c7ec8a5776fee6d56251bd89762950727dfc81fa33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Xiuhe</creatorcontrib><creatorcontrib>Zhang, Peiyan</creatorcontrib><creatorcontrib>Cui, Qingke</creatorcontrib><creatorcontrib>He, Xiaoli</creatorcontrib><creatorcontrib>Pan, Lizhu</creatorcontrib><creatorcontrib>Zhou, Zhuojun</creatorcontrib><creatorcontrib>Li, Jiayue</creatorcontrib><creatorcontrib>Wang, Caixia</creatorcontrib><creatorcontrib>Yang, Xiaojuan</creatorcontrib><creatorcontrib>Zhu, Guiqi</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>CrossRef</collection><jtitle>Natural product communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Xiuhe</au><au>Zhang, Peiyan</au><au>Cui, Qingke</au><au>He, Xiaoli</au><au>Pan, Lizhu</au><au>Zhou, Zhuojun</au><au>Li, Jiayue</au><au>Wang, Caixia</au><au>Yang, Xiaojuan</au><au>Zhu, Guiqi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Acacia Honey on Serum Uric Acid Level and Liver Injury in Rats</atitle><jtitle>Natural product communications</jtitle><date>2024-12</date><risdate>2024</risdate><volume>19</volume><issue>12</issue><issn>1934-578X</issn><eissn>1555-9475</eissn><abstract>Objective
Honey is generally considered to be a natural product with rich nutritional value. However, the fructose contained in honey is harmful to the liver. This study aims to observe the effect of acacia honey (AH) on serum uric acid and liver injury in potassium oxonate model rats after drinking AH aqueous solution.
Materials and methods
Sixty male Sprague-Dawley (SD) rats were selected and randomly divided into control group (CON group), potassium oxonate model group (OA model group), 10% fructose group (10%F group) and different concentration AH groups (25%, 12.5% and 6.25% AH groups). 100 mg/kg OA solution combined with fructose solution or AH solution was administered to gavage model rats. After the 4 weeks test, blood and liver tissues were collected, serum uric acid content, biochemical indexes, activities of alanine transaminase and alanine transaminase were determined, and liver histological sections were observed.
Results
AH can significantly increase serum uric acid level, liver weight and liver to body weight ratio (p < 0.05). The levels of serum triglyceride (TG), free fatty acid (FFA), and high-density fatty acid cholesterol (HDL-C) were elevated in 25% and 12.5% AH groups compared with CON group or OA model group (p < 0.05), but serum levels of TG, FFA, HDL-C, total cholesterol (T-CHO) and low density lipoprotein cholesterol (LDL-C) were significantly increased in 6.25%AH group (p < 0.05).
Conclusion
AH can cause fatty liver disease in all rats in a dose dependent manner. In the dose range of the present study, AH can induce hyperuricemia, hypertriglyceridemia and fatty liver disease.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><doi>10.1177/1934578X241302566</doi><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Sage Journals GOLD Open Access 2024; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| title | Effect of Acacia Honey on Serum Uric Acid Level and Liver Injury in Rats |
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