Chemical Constituents of Tagetes patula and Their Neuroprotecting Action
Two novel flavonoids (1, 2) and 3 known compounds (3-5) were isolated from the flowers and whole plant of Tagetes patula L., and their structures were elucidated by means of ultra-high performance liquid chromatography with electrospray ionization, coupled to quadrupole-time-of-flight/mass spectrome...
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| Veröffentlicht in: | Natural product communications 2020-11, Vol.15 (11) |
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| creator | Liu, Linlin Luo, Simin Yu, Miao Metwaly, Ahmed M. Ran, Xiaoku Ma, Chunyan Dou, Deqiang Cai, Decheng |
| description | Two novel flavonoids (1, 2) and 3 known compounds (3-5) were isolated from the flowers and whole plant of Tagetes patula L., and their structures were elucidated by means of ultra-high performance liquid chromatography with electrospray ionization, coupled to quadrupole-time-of-flight/mass spectrometry, 1H and 13C-nuclear magnetic resonance (NMR), as well as 2-dimensional-NMR (heteronuclear single quantum correlation and heteronuclear multiple bond correlation) and chemical methods. In addition, all the compounds were examined for their neuroprotective action on the injury of SH-SY5Y cells induced by glutamate, indicating that the protective effect of these compounds on glutamate-induced SH-SY5Y cell was marigold biflavone > patuletin > quercetin > kaempferol-3-O-β-d-glucoside > patuletin-3-O-α-l-arabinopyranoside. Thus, it could be concluded that flavonoids played a key role in the neuroprotective action of T. patula. |
| doi_str_mv | 10.1177/1934578X20974507 |
| format | Article |
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In addition, all the compounds were examined for their neuroprotective action on the injury of SH-SY5Y cells induced by glutamate, indicating that the protective effect of these compounds on glutamate-induced SH-SY5Y cell was marigold biflavone > patuletin > quercetin > kaempferol-3-O-β-d-glucoside > patuletin-3-O-α-l-arabinopyranoside. 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In addition, all the compounds were examined for their neuroprotective action on the injury of SH-SY5Y cells induced by glutamate, indicating that the protective effect of these compounds on glutamate-induced SH-SY5Y cell was marigold biflavone > patuletin > quercetin > kaempferol-3-O-β-d-glucoside > patuletin-3-O-α-l-arabinopyranoside. 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| title | Chemical Constituents of Tagetes patula and Their Neuroprotecting Action |
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