Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2
The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Pelargonidin (PEL) is a well-known red pigment...
Gespeichert in:
| Veröffentlicht in: | Natural product communications 2018-08, Vol.13 (8) |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | |
| container_title | Natural product communications |
| container_volume | 13 |
| creator | Lee, In-Chul Bae, Jong-Sup |
| description | The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Pelargonidin (PEL) is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. Here, PEL was examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mouse. Post treatment of cells or mouse with PEL inhibited LPS-induced expression and activity of sPLA2-IIA. Therefore, these results suggest that PEL inhibited LPS mediated expression of sPLA2-IIA. |
| doi_str_mv | 10.1177/1934578X1801300811 |
| format | Article |
| fullrecord | <record><control><sourceid>sage_AFRWT</sourceid><recordid>TN_cdi_crossref_primary_10_1177_1934578X1801300811</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1934578X1801300811</sage_id><sourcerecordid>10.1177_1934578X1801300811</sourcerecordid><originalsourceid>FETCH-LOGICAL-c331t-c8e68296bc796def80fdaca9057254452f341e28db0fd90ec11d271f0984cfd23</originalsourceid><addsrcrecordid>eNp9kFFLwzAQx4MoOOa-gE_5AnW5NGmSxzLmLAwcqOBbSdNk7ahNSbaHfXsz55vgvdzB_X7H8UfoEcgTgBBLUDnjQn6CJJATIgFu0Aw455ligt-mOQHZhbhHixgPJJWUjDA1Q1U1dn3TH30447Vz1hyxd3hnBx32fuzbfsR-xG_WBPvDbII_TbiqSrzrfJw6P_STjhaX9AHdOT1Eu_jtc_TxvH5fvWTb1021KreZyXM4ZkbaQlJVNEaoorVOEtdqoxXhgnLGOHU5A0tl26SFItYAtFSAI0oy41qazxG93jXBxxisq6fQf-lwroHUlzzqv3kkaXmVot7b-uBPYUw__md8A1cSX-o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2</title><source>Sage Journals GOLD Open Access 2024</source><creator>Lee, In-Chul ; Bae, Jong-Sup</creator><creatorcontrib>Lee, In-Chul ; Bae, Jong-Sup</creatorcontrib><description>The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Pelargonidin (PEL) is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. Here, PEL was examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mouse. Post treatment of cells or mouse with PEL inhibited LPS-induced expression and activity of sPLA2-IIA. Therefore, these results suggest that PEL inhibited LPS mediated expression of sPLA2-IIA.</description><identifier>ISSN: 1934-578X</identifier><identifier>EISSN: 1555-9475</identifier><identifier>DOI: 10.1177/1934578X1801300811</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><ispartof>Natural product communications, 2018-08, Vol.13 (8)</ispartof><rights>2018 SAGE Publications Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-c8e68296bc796def80fdaca9057254452f341e28db0fd90ec11d271f0984cfd23</citedby><cites>FETCH-LOGICAL-c331t-c8e68296bc796def80fdaca9057254452f341e28db0fd90ec11d271f0984cfd23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300811$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1934578X1801300811$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21965,27852,27923,27924,44944,45332</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1934578X1801300811?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc></links><search><creatorcontrib>Lee, In-Chul</creatorcontrib><creatorcontrib>Bae, Jong-Sup</creatorcontrib><title>Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2</title><title>Natural product communications</title><description>The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Pelargonidin (PEL) is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. Here, PEL was examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mouse. Post treatment of cells or mouse with PEL inhibited LPS-induced expression and activity of sPLA2-IIA. Therefore, these results suggest that PEL inhibited LPS mediated expression of sPLA2-IIA.</description><issn>1934-578X</issn><issn>1555-9475</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kFFLwzAQx4MoOOa-gE_5AnW5NGmSxzLmLAwcqOBbSdNk7ahNSbaHfXsz55vgvdzB_X7H8UfoEcgTgBBLUDnjQn6CJJATIgFu0Aw455ligt-mOQHZhbhHixgPJJWUjDA1Q1U1dn3TH30447Vz1hyxd3hnBx32fuzbfsR-xG_WBPvDbII_TbiqSrzrfJw6P_STjhaX9AHdOT1Eu_jtc_TxvH5fvWTb1021KreZyXM4ZkbaQlJVNEaoorVOEtdqoxXhgnLGOHU5A0tl26SFItYAtFSAI0oy41qazxG93jXBxxisq6fQf-lwroHUlzzqv3kkaXmVot7b-uBPYUw__md8A1cSX-o</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Lee, In-Chul</creator><creator>Bae, Jong-Sup</creator><general>SAGE Publications</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201808</creationdate><title>Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2</title><author>Lee, In-Chul ; Bae, Jong-Sup</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-c8e68296bc796def80fdaca9057254452f341e28db0fd90ec11d271f0984cfd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, In-Chul</creatorcontrib><creatorcontrib>Bae, Jong-Sup</creatorcontrib><collection>CrossRef</collection><jtitle>Natural product communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Lee, In-Chul</au><au>Bae, Jong-Sup</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2</atitle><jtitle>Natural product communications</jtitle><date>2018-08</date><risdate>2018</risdate><volume>13</volume><issue>8</issue><issn>1934-578X</issn><eissn>1555-9475</eissn><abstract>The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Pelargonidin (PEL) is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. Here, PEL was examined for its effects on the expression and activity of sPLA2-IIA in HUVECs and mouse. Post treatment of cells or mouse with PEL inhibited LPS-induced expression and activity of sPLA2-IIA. Therefore, these results suggest that PEL inhibited LPS mediated expression of sPLA2-IIA.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><doi>10.1177/1934578X1801300811</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1934-578X |
| ispartof | Natural product communications, 2018-08, Vol.13 (8) |
| issn | 1934-578X 1555-9475 |
| language | eng |
| recordid | cdi_crossref_primary_10_1177_1934578X1801300811 |
| source | Sage Journals GOLD Open Access 2024 |
| title | Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T21%3A14%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-sage_AFRWT&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inhibitory%20Effect%20of%20Pelargonidin%20on%20Secretory%20Group%20IIA%20Phospholipase%20A2&rft.jtitle=Natural%20product%20communications&rft.au=Lee,%20In-Chul&rft.date=2018-08&rft.volume=13&rft.issue=8&rft.issn=1934-578X&rft.eissn=1555-9475&rft_id=info:doi/10.1177/1934578X1801300811&rft_dat=%3Csage_AFRWT%3E10.1177_1934578X1801300811%3C/sage_AFRWT%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_sage_id=10.1177_1934578X1801300811&rfr_iscdi=true |