Chemical Constituents of Sinningia hatschbachii
A new naphthoquinone, 6-hydroxy-7-methoxy-2-O-methylduniol (1), was isolated from the tubers of Sinningia hatschbachii Chautems (Gesneriaceae), together with 10 known compounds: 7-hydroxy-α-dunnione, 7-hydroxy-6-methoxy-α-dunnione, 2,4,4’,6-tetramethoxydihydrochalcone, 4’-hydroxy-2,4,6-trimethoxydih...
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| Veröffentlicht in: | Natural product communications 2017-11, Vol.12 (11) |
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| creator | Amorim, Magali S. Serain, Alessandra F. Salvador, Marcos José Stefanello, Maria Élida A. |
| description | A new naphthoquinone, 6-hydroxy-7-methoxy-2-O-methylduniol (1), was isolated from the tubers of Sinningia hatschbachii Chautems (Gesneriaceae), together with 10 known compounds: 7-hydroxy-α-dunnione, 7-hydroxy-6-methoxy-α-dunnione, 2,4,4’,6-tetramethoxydihydrochalcone, 4’-hydroxy-2,4,6-trimethoxydihydrochalcone, 4’,2-dihydroxy-4,6-dimethoxydihydrochalcone, methyl 1-hydroxy-4-methoxy-2-naphthoate, methyl 1,4-dimethoxy-2-naphthoate, methyl 4-hydroxybenzoate, calceolarioside B, and conandroside. All compounds were identified by spectroscopic techniques, and comparison with literature. Extracts in hexane, CH2Cl2, EtOAc and EtOH were evaluated for antimicrobial activity against Staphylococcus aureus, S. epidermidis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, C. dubliniensis, C. glabrata, and C. parapsilosis. All extracts were inactive. |
| doi_str_mv | 10.1177/1934578X1701201128 |
| format | Article |
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All compounds were identified by spectroscopic techniques, and comparison with literature. Extracts in hexane, CH2Cl2, EtOAc and EtOH were evaluated for antimicrobial activity against Staphylococcus aureus, S. epidermidis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, C. dubliniensis, C. glabrata, and C. parapsilosis. 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| title | Chemical Constituents of Sinningia hatschbachii |
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