Proliferation Effects on Hair Growth of Compounds Isolated from the Bark of Dalbergia oliveri

One new isoflavane, 7,4′-dihydroxy-isoflavanquinone (1), together with ten known compounds (2–11) were isolated from the bark of Dalbergia oliveri Prain. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. Us...

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Veröffentlicht in:Natural product communications 2017-11, Vol.12 (11)
Hauptverfasser: Park, Seon Ju, Nhiem, Nguyen Xuan, Tai, Bui Huu, Le Tuan Anh, Hoang, Oh, Seok Hyun, Sung, Jong-Hyuk, Kim, Nanyoung, Yoo, Guijae, Park, Jun Hyung, Kwak, Hee Jae, Loan, Pham Thanh, Kim, Seung Hyun, Van Kiem, Phan
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container_issue 11
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container_title Natural product communications
container_volume 12
creator Park, Seon Ju
Nhiem, Nguyen Xuan
Tai, Bui Huu
Le Tuan Anh, Hoang
Oh, Seok Hyun
Sung, Jong-Hyuk
Kim, Nanyoung
Yoo, Guijae
Park, Jun Hyung
Kwak, Hee Jae
Loan, Pham Thanh
Kim, Seung Hyun
Van Kiem, Phan
description One new isoflavane, 7,4′-dihydroxy-isoflavanquinone (1), together with ten known compounds (2–11) were isolated from the bark of Dalbergia oliveri Prain. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 1D and 2D NMR and CD spectroscopic data. Using a cell proliferation assay, the isolated compounds were evaluated for their proliferation effects on hair growth. (3R)-5’-Methoxyvestitol (2) and (6aR,11aR)-3,8-dihydroxy-9-methoxypterocarpan (10) significantly increased the proliferation of immortalized dermal papilla cells (iDPC).
doi_str_mv 10.1177/1934578X1701201117
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title Proliferation Effects on Hair Growth of Compounds Isolated from the Bark of Dalbergia oliveri
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