Synthesis and Cytotoxic Evaluation of Novel Ester Derivatives of Betulin with AZT, d4T, and 3TC

Novel ester derivatives of betulin with AZT, d4T, and 3TC were synthesized and assessed for antitumor activities against the KB and HepG2 human cancer cell lines in vitro by MTT assay. Some derivatives displayed high anticancer properties, with IC50 values between 1 and 21 μM on the two cancer cell...

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Veröffentlicht in:	Natural product communications 2017-06, Vol.12 (6)
Hauptverfasser:	Anh, Dang Thi Tuyet, Giang, Le Nhat Thuy, Hien, Nguyen Thi, Cuc, Dinh Thi, Thanh, Nguyen Ha, Tra, Nguyen Thanh, Phuong, Hoang Thi, Van Tuyen, Nguyen, Van Kiem, Phan
Format:	Artikel
Sprache:	eng
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Zusammenfassung:	Novel ester derivatives of betulin with AZT, d4T, and 3TC were synthesized and assessed for antitumor activities against the KB and HepG2 human cancer cell lines in vitro by MTT assay. Some derivatives displayed high anticancer properties, with IC50 values between 1 and 21 μM on the two cancer cell lines.
ISSN:	1934-578X 1555-9475
DOI:	10.1177/1934578X1701200613