Cytotoxic Activity of seco-Entkaurenes from Croton caracasana on Human Cancer Cell Lines
In the course of searching for bioactive compounds from Croton species from Venezuela, two seco-entkaurenes isolated from flowers of Croton caracasana were evaluated in vitro for their effect on cell viability by the standard MTT assay in nine human cancer cell lines of different origins and one pri...
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| Veröffentlicht in: | Natural product communications 2009-11, Vol.4 (11), p.1547 |
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| creator | Suárez, Alírica I. Chavez, Katiuska Mateu, Elsa Compagnone, Reinaldo S. Muñoz, Arturo Sojo, Felipe Arvelo, Francisco Mijares, Michael De Sanctis, Juan B. |
| description | In the course of searching for bioactive compounds from Croton species from Venezuela, two seco-entkaurenes isolated from flowers of Croton caracasana were evaluated in vitro for their effect on cell viability by the standard MTT assay in nine human cancer cell lines of different origins and one primary culture. Both compounds induced cytotoxicity in the range of 2 to 25 μM for caracasine and 0.8 to 12 μM for caracasine acid. However, for the normal fibroblasts and the cell lines, HeLa, MCF-7, PC-3, LoVo, X-17, Jurkat E6.1 and Jurkat JCaM1.6, the IC50 values of caracasine acid were lower than their counterparts. Interestingly, no differences in IC50 were recorded for the leukemic cell lines U937 and K562. It can be concluded that the acid moiety in the structure enhances the cytotoxic effect of caracasine by a pathway which seems not to be activated in the leukemic cell lines tested. |
| doi_str_mv | 10.1177/1934578X0900401117 |
| format | Article |
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Both compounds induced cytotoxicity in the range of 2 to 25 μM for caracasine and 0.8 to 12 μM for caracasine acid. However, for the normal fibroblasts and the cell lines, HeLa, MCF-7, PC-3, LoVo, X-17, Jurkat E6.1 and Jurkat JCaM1.6, the IC50 values of caracasine acid were lower than their counterparts. Interestingly, no differences in IC50 were recorded for the leukemic cell lines U937 and K562. It can be concluded that the acid moiety in the structure enhances the cytotoxic effect of caracasine by a pathway which seems not to be activated in the leukemic cell lines tested.</description><identifier>ISSN: 1934-578X</identifier><identifier>EISSN: 1555-9475</identifier><identifier>DOI: 10.1177/1934578X0900401117</identifier><identifier>PMID: 19967987</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - pharmacology ; Cell Line, Tumor ; Cell Survival - drug effects ; Coloring Agents ; Croton - chemistry ; Diterpenes - chemistry ; Diterpenes - pharmacology ; Drug Screening Assays, Antitumor ; Flowers - chemistry ; Humans ; Tetrazolium Salts ; Thiazoles</subject><ispartof>Natural product communications, 2009-11, Vol.4 (11), p.1547</ispartof><rights>2009 SAGE Publications Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-df2592ed15cea928b13e2668d1d0bc7e368cc9e46b9b0cf812dfffa1e8625e993</citedby><cites>FETCH-LOGICAL-c354t-df2592ed15cea928b13e2668d1d0bc7e368cc9e46b9b0cf812dfffa1e8625e993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1934578X0900401117$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1934578X0900401117$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21971,27858,27929,27930,44950,45338</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1934578X0900401117?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19967987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suárez, Alírica I.</creatorcontrib><creatorcontrib>Chavez, Katiuska</creatorcontrib><creatorcontrib>Mateu, Elsa</creatorcontrib><creatorcontrib>Compagnone, Reinaldo S.</creatorcontrib><creatorcontrib>Muñoz, Arturo</creatorcontrib><creatorcontrib>Sojo, Felipe</creatorcontrib><creatorcontrib>Arvelo, Francisco</creatorcontrib><creatorcontrib>Mijares, Michael</creatorcontrib><creatorcontrib>De Sanctis, Juan B.</creatorcontrib><title>Cytotoxic Activity of seco-Entkaurenes from Croton caracasana on Human Cancer Cell Lines</title><title>Natural product communications</title><addtitle>Nat Prod Commun</addtitle><description>In the course of searching for bioactive compounds from Croton species from Venezuela, two seco-entkaurenes isolated from flowers of Croton caracasana were evaluated in vitro for their effect on cell viability by the standard MTT assay in nine human cancer cell lines of different origins and one primary culture. Both compounds induced cytotoxicity in the range of 2 to 25 μM for caracasine and 0.8 to 12 μM for caracasine acid. However, for the normal fibroblasts and the cell lines, HeLa, MCF-7, PC-3, LoVo, X-17, Jurkat E6.1 and Jurkat JCaM1.6, the IC50 values of caracasine acid were lower than their counterparts. Interestingly, no differences in IC50 were recorded for the leukemic cell lines U937 and K562. It can be concluded that the acid moiety in the structure enhances the cytotoxic effect of caracasine by a pathway which seems not to be activated in the leukemic cell lines tested.</description><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Coloring Agents</subject><subject>Croton - chemistry</subject><subject>Diterpenes - chemistry</subject><subject>Diterpenes - pharmacology</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Flowers - chemistry</subject><subject>Humans</subject><subject>Tetrazolium Salts</subject><subject>Thiazoles</subject><issn>1934-578X</issn><issn>1555-9475</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN9KwzAUxoMobsy9gBeSF6hL0qRJLkeZThh4o7C7kqYn0rk2I2nFvb0ZG3gheG7OH37fB-dD6J6SR0qlXFCdcyHVlmhCOKHpdoWmVAiRaS7FdZoTkJ2ICZrHuCOplOKE61s0oVoXUis5RdvyOPjBf7cWL-3QfrXDEXuHI1ifrfrh04wBeojYBd_hMiS0x9YEY000vcFpW4-d6XFpegsBl7Df402bFHfoxpl9hPmlz9D70-qtXGeb1-eXcrnJbC74kDWOCc2gocKC0UzVNAdWFKqhDamthLxQ1mrgRa1rYp2irHHOGQqqYAK0zmeInX1t8DEGcNUhtJ0Jx4qS6pRU9TepJHo4iw5j3UHzK7nkkoDFGYjmA6qdH0OfnvjP8gf6q3Ih</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Suárez, Alírica I.</creator><creator>Chavez, Katiuska</creator><creator>Mateu, Elsa</creator><creator>Compagnone, Reinaldo S.</creator><creator>Muñoz, Arturo</creator><creator>Sojo, Felipe</creator><creator>Arvelo, Francisco</creator><creator>Mijares, Michael</creator><creator>De Sanctis, Juan B.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20091101</creationdate><title>Cytotoxic Activity of seco-Entkaurenes from Croton caracasana on Human Cancer Cell Lines</title><author>Suárez, Alírica I. ; Chavez, Katiuska ; Mateu, Elsa ; Compagnone, Reinaldo S. ; Muñoz, Arturo ; Sojo, Felipe ; Arvelo, Francisco ; Mijares, Michael ; De Sanctis, Juan B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-df2592ed15cea928b13e2668d1d0bc7e368cc9e46b9b0cf812dfffa1e8625e993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Coloring Agents</topic><topic>Croton - chemistry</topic><topic>Diterpenes - chemistry</topic><topic>Diterpenes - pharmacology</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Flowers - chemistry</topic><topic>Humans</topic><topic>Tetrazolium Salts</topic><topic>Thiazoles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suárez, Alírica I.</creatorcontrib><creatorcontrib>Chavez, Katiuska</creatorcontrib><creatorcontrib>Mateu, Elsa</creatorcontrib><creatorcontrib>Compagnone, Reinaldo S.</creatorcontrib><creatorcontrib>Muñoz, Arturo</creatorcontrib><creatorcontrib>Sojo, Felipe</creatorcontrib><creatorcontrib>Arvelo, Francisco</creatorcontrib><creatorcontrib>Mijares, Michael</creatorcontrib><creatorcontrib>De Sanctis, Juan B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Natural product communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Suárez, Alírica I.</au><au>Chavez, Katiuska</au><au>Mateu, Elsa</au><au>Compagnone, Reinaldo S.</au><au>Muñoz, Arturo</au><au>Sojo, Felipe</au><au>Arvelo, Francisco</au><au>Mijares, Michael</au><au>De Sanctis, Juan B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic Activity of seco-Entkaurenes from Croton caracasana on Human Cancer Cell Lines</atitle><jtitle>Natural product communications</jtitle><addtitle>Nat Prod Commun</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>4</volume><issue>11</issue><spage>1547</spage><pages>1547-</pages><issn>1934-578X</issn><eissn>1555-9475</eissn><abstract>In the course of searching for bioactive compounds from Croton species from Venezuela, two seco-entkaurenes isolated from flowers of Croton caracasana were evaluated in vitro for their effect on cell viability by the standard MTT assay in nine human cancer cell lines of different origins and one primary culture. Both compounds induced cytotoxicity in the range of 2 to 25 μM for caracasine and 0.8 to 12 μM for caracasine acid. However, for the normal fibroblasts and the cell lines, HeLa, MCF-7, PC-3, LoVo, X-17, Jurkat E6.1 and Jurkat JCaM1.6, the IC50 values of caracasine acid were lower than their counterparts. Interestingly, no differences in IC50 were recorded for the leukemic cell lines U937 and K562. It can be concluded that the acid moiety in the structure enhances the cytotoxic effect of caracasine by a pathway which seems not to be activated in the leukemic cell lines tested.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>19967987</pmid><doi>10.1177/1934578X0900401117</doi><oa>free_for_read</oa></addata></record> |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Cell Line, Tumor Cell Survival - drug effects Coloring Agents Croton - chemistry Diterpenes - chemistry Diterpenes - pharmacology Drug Screening Assays, Antitumor Flowers - chemistry Humans Tetrazolium Salts Thiazoles |
| title | Cytotoxic Activity of seco-Entkaurenes from Croton caracasana on Human Cancer Cell Lines |
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