Major Constituents of the Predominant Endophytic Fungi from the Nigerian Plants Bryophyllum Pinnatum, Morinda Lucida and Jathropha Gossypiifolia

Major Constituents of the Predominant Endophytic Fungi from the Nigerian Plants Bryophyllum Pinnatum, Morinda Lucida and Jathropha Gossypiifolia

In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while As...

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Veröffentlicht in:Natural product communications 2008-08, Vol.3 (8)
Hauptverfasser: Sowemimo, Abimbola A., Edrada-Ebel, RuAngelie, Ebel, Rainer, Proksch, Peter, Omobuwajo, Olanrewaju R., Adesanya, Saburi A.
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container_issue 8
container_start_page
container_title Natural product communications
container_volume 3
creator Sowemimo, Abimbola A.
Edrada-Ebel, RuAngelie
Ebel, Rainer
Proksch, Peter
Omobuwajo, Olanrewaju R.
Adesanya, Saburi A.
description In a chemical screening of fungal strains endophytic to Nigerian plants, Diaporthe phaseolorum, the endophyte of Bryophyllum pinnatum, gave cytochalasin D and (3R,4R)-3,4,5-trihydroxy-1-tetralone, Neurospora discreta from Morinda lucida yielded multiforisin I and 4-hydroxyphenylacetic acid, while Aspergillus japonicus from Jatropha gossypiifolia gave (+)-eupenoxide and microsphaerone C, a new 4-pyridone derivative. When tested for cytotoxic activity, cytochalasin D displayed strong activity towards the mouse lymphoma cell line L5178Y, while the remaining compounds, except 4-hydroxyphenylacetic acid, were found to be moderately active.
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title Major Constituents of the Predominant Endophytic Fungi from the Nigerian Plants Bryophyllum Pinnatum, Morinda Lucida and Jathropha Gossypiifolia
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