Subereaphenol A, a new Cytotoxic and Antimicrobial Dibrominated Phenol from the Red Sea Sponge Suberea Mollis

An investigation of the sponge Suberea mollis collected at the Egyptian Red Sea coast afforded a new cytotoxic and antimicrobial dibrominated phenol, subereaphenol A (1), together with the previously reported compounds 2-(3′,5′-dibromo-2′-hydroxy-4′-methoxyphenyl)acetamide (2), dibromoverongiaquinol (3), bromochloroverongiaquinol (4), and 2-(3′,5′-dibromo-4′-ethoxy-1′-hydroxy-4′-methoxy-2′,5′-cyclohexadien-1-yl)acetamide (5). The structure of the compounds was determined by a combination of 1D and 2D NMR techniques and High-resolution mass spectral determinations. Complete and new NMR data for the known compounds has been reported. The cytotoxic and the antimicrobial activities of the compounds are reported.