Transforming Growth Factor β1 Gene Polymorphism —509C/T in Deep Infiltrating Endometriosis

Transforming Growth Factor β1 Gene Polymorphism —509C/T in Deep Infiltrating Endometriosis

Deep infiltrating endometriosis is characterized by the presence of nodular lesions largely composed of fibromuscular tissue. Transforming growth factor beta 1 (TGF-β1) is the cytokine most causatively associated with disorders characterized by fibrosis throughout the body. Therefore, the hypothesis...

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Veröffentlicht in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2007-05, Vol.14 (4), p.367-373
Hauptverfasser: van Kaam, K. J. A. F., Romano, A., Dunselman, G. A. J., Groothuis, P. G.
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Sprache:eng
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Biological and medical sciences
Female genital diseases
Gynecology. Andrology. Obstetrics
Medical sciences
Non tumoral diseases
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container_end_page 373
container_issue 4
container_start_page 367
container_title Reproductive sciences (Thousand Oaks, Calif.)
container_volume 14
creator van Kaam, K. J. A. F.
Romano, A.
Dunselman, G. A. J.
Groothuis, P. G.
description Deep infiltrating endometriosis is characterized by the presence of nodular lesions largely composed of fibromuscular tissue. Transforming growth factor beta 1 (TGF-β1) is the cytokine most causatively associated with disorders characterized by fibrosis throughout the body. Therefore, the hypothesis was tested that mechanisms increasing the fraction of biologically active TGF-β1, such as TGF-β 1 gene polymorphisms, lead to an increased risk of developing deep infiltrating endometriosis. The frequency of the -509C/T polymorphism of the TGF-β 1 gene was tested in women with deep infiltrating endometriosis (n = 72), gynecological patients without symptoms of endometriosis (n = 95) and healthy females (n = 93). Detection of the -509C/T polymorphisms was performed using PCR-restriction fragment length polymorphism analysis. We did not observe statistically significant differences in the frequency of the -509C/T polymorphism between the groups. Our study does not support an association between the −509C/T polymorphism of the TGF-β 1 gene and an increased risk of deep infiltrating endometriosis.
doi_str_mv 10.1177/1933719107303436
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subjects Biological and medical sciences
Female genital diseases
Gynecology. Andrology. Obstetrics
Medical sciences
Non tumoral diseases
title Transforming Growth Factor β1 Gene Polymorphism —509C/T in Deep Infiltrating Endometriosis
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