Production of a p65 fl/fl /LysMCre mouse model with dysfunctional NF-κB signaling in bone marrow-derived macrophages

Here, we describe the production and characterization of a novel p65 /LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signalin...

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Veröffentlicht in:	Innate immunity (London, England) England), 2023-11, Vol.29 (8), p.171-185
Hauptverfasser:	Korkaya, Ahmet K, Fischer, Jeffrey, Peppers, Anthony, Crosson, Sean M, Rayamajhi, Manira, Miao, Edward A, Baldwin, Jr, Albert S, Bradford, Jennifer W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Female Macrophages Mice NF-kappa B - metabolism Signal Transduction Transcription Factor RelA
Online-Zugang:	Volltext
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