K562 cell sensitization to 5-fluorouracil- or interferon-alpha-induced apoptosis via cordycepin (3'-deoxyadenosine): Fine control of cell apoptosis via poly(A) polymerase upregulation

K562 cells represent a classical model for the study of drug resistance. Induction of apoptosis is accompanied by concomitant distinct modulations of poly(A) polymerase (PAP) and other proteins involved in mRNA maturation. Recent data suggest the involvement of mRNA stability in the induction of spe...

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Veröffentlicht in:	The International journal of biological markers 2004, Vol.19 (1), p.58-66
Hauptverfasser:	LALLAS, G. C, COURTIS, N, HAVREDAKI, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Apoptosis Biological and medical sciences Blotting, Western Cell Nucleus - metabolism Cell Separation Cell Survival Coloring Agents - pharmacology Deoxyadenosines - pharmacology DNA - chemistry DNA Fragmentation Flow Cytometry Fluorouracil - pharmacology Fundamental and applied biological sciences. Psychology Humans Immunoblotting Indoles - pharmacology Interferon-alpha - pharmacology Investigative techniques, diagnostic techniques (general aspects) K562 Cells Medical sciences Membrane Potentials Mitochondria - metabolism Polyadenylation Polynucleotide Adenylyltransferase - biosynthesis Protein Isoforms RNA, Messenger - metabolism Tetrazolium Salts - pharmacology Thiazoles - pharmacology Time Factors Up-Regulation
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