Is the Remarkable Contradiction between Histology and 14 C Urea Breath Test in the Detection of Helicobacter pylori due to False-negative Histology or False-positive 14 C Urea Breath Test?
We assessed the diagnostic value of the 14 C urea breath test (UBT) in the detection of Helicobacter pylori compared with histology and the rapid urease test (RUT). The study included 68 patients (22 men and 46 women) with dyspeptic symptoms. H. pylori status was evaluated by 14 C UBT, RUT and histo...
Gespeichert in:
| Veröffentlicht in: | Journal of international medical research 2005-11, Vol.33 (6), p.632-640 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 640 |
|---|---|
| container_issue | 6 |
| container_start_page | 632 |
| container_title | Journal of international medical research |
| container_volume | 33 |
| creator | Gurbuz, AK Ozel, AM Narin, Y Yazgan, Y Baloglu, H Demirturk, L |
| description | We assessed the diagnostic value of the
14
C urea breath test (UBT) in the detection of Helicobacter pylori compared with histology and the rapid urease test (RUT). The study included 68 patients (22 men and 46 women) with dyspeptic symptoms. H. pylori status was evaluated by
14
C UBT, RUT and histology. Sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy were determined for
14
C UBT and for RUT. Histology revealed dense yeast-like micro-organisms in the biopsy specimens in all patients with false-positive results by
14
C UBT (n = 8), a significantly higher proportion than in patients with negative
14
C UBT (five of 31). The low specificity of the H. pylori
14
C UBT should not be neglected by accepting histology results as false-negative. Gastric mucosal colonization by yeast-like micro-organisms with urease activity can account for the high frequency of false-positive results for
14
C UBT. |
| doi_str_mv | 10.1177/147323000503300604 |
| format | Article |
| fullrecord | <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_1177_147323000503300604</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1177_147323000503300604</sourcerecordid><originalsourceid>FETCH-LOGICAL-c924-4ddd5970eb9583eef1ff9f36110a58f448a341dcdd1da9df34a6ec51fe7840db3</originalsourceid><addsrcrecordid>eNptUEtOwzAUtBBIlMIFWL0LBOzY-a0QBEorVUJCZR058XNrCHFlG1DuxuFI2i6QYPNGmpk3Iw0hl4xeMZZl10xkPOaU0oTyAVIqjshkJKORPSYTOkA08MkpOfP-lVIRp0k8Id8LD2GD8Izv0r3JukUobRecVKYJxnZQY_hC7GBufLCtXfcgOwVMQAkvDiXcDSdsYIU-gOl2WfcYcP9sNcyxNY2tZRPQwbZvrTOgPhCChZlsPUYdrmUwn_irwbqDtrXe7LR_-27OyYkefRcHnJLV7GFVzqPl0-OivF1GTRGLSCilkiKjWBdJzhE107rQPGWMyiTXQuSSC6YapZiShdJcyBSbhGnMckFVzack3sc2znrvUFdbZ4a5-orRapy_-js__wHNRXoU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Is the Remarkable Contradiction between Histology and 14 C Urea Breath Test in the Detection of Helicobacter pylori due to False-negative Histology or False-positive 14 C Urea Breath Test?</title><source>Sage Journals GOLD Open Access 2024</source><source>Alma/SFX Local Collection</source><creator>Gurbuz, AK ; Ozel, AM ; Narin, Y ; Yazgan, Y ; Baloglu, H ; Demirturk, L</creator><creatorcontrib>Gurbuz, AK ; Ozel, AM ; Narin, Y ; Yazgan, Y ; Baloglu, H ; Demirturk, L</creatorcontrib><description>We assessed the diagnostic value of the
14
C urea breath test (UBT) in the detection of Helicobacter pylori compared with histology and the rapid urease test (RUT). The study included 68 patients (22 men and 46 women) with dyspeptic symptoms. H. pylori status was evaluated by
14
C UBT, RUT and histology. Sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy were determined for
14
C UBT and for RUT. Histology revealed dense yeast-like micro-organisms in the biopsy specimens in all patients with false-positive results by
14
C UBT (n = 8), a significantly higher proportion than in patients with negative
14
C UBT (five of 31). The low specificity of the H. pylori
14
C UBT should not be neglected by accepting histology results as false-negative. Gastric mucosal colonization by yeast-like micro-organisms with urease activity can account for the high frequency of false-positive results for
14
C UBT.</description><identifier>ISSN: 0300-0605</identifier><identifier>EISSN: 1473-2300</identifier><identifier>DOI: 10.1177/147323000503300604</identifier><language>eng</language><ispartof>Journal of international medical research, 2005-11, Vol.33 (6), p.632-640</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c924-4ddd5970eb9583eef1ff9f36110a58f448a341dcdd1da9df34a6ec51fe7840db3</citedby><cites>FETCH-LOGICAL-c924-4ddd5970eb9583eef1ff9f36110a58f448a341dcdd1da9df34a6ec51fe7840db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Gurbuz, AK</creatorcontrib><creatorcontrib>Ozel, AM</creatorcontrib><creatorcontrib>Narin, Y</creatorcontrib><creatorcontrib>Yazgan, Y</creatorcontrib><creatorcontrib>Baloglu, H</creatorcontrib><creatorcontrib>Demirturk, L</creatorcontrib><title>Is the Remarkable Contradiction between Histology and 14 C Urea Breath Test in the Detection of Helicobacter pylori due to False-negative Histology or False-positive 14 C Urea Breath Test?</title><title>Journal of international medical research</title><description>We assessed the diagnostic value of the
14
C urea breath test (UBT) in the detection of Helicobacter pylori compared with histology and the rapid urease test (RUT). The study included 68 patients (22 men and 46 women) with dyspeptic symptoms. H. pylori status was evaluated by
14
C UBT, RUT and histology. Sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy were determined for
14
C UBT and for RUT. Histology revealed dense yeast-like micro-organisms in the biopsy specimens in all patients with false-positive results by
14
C UBT (n = 8), a significantly higher proportion than in patients with negative
14
C UBT (five of 31). The low specificity of the H. pylori
14
C UBT should not be neglected by accepting histology results as false-negative. Gastric mucosal colonization by yeast-like micro-organisms with urease activity can account for the high frequency of false-positive results for
14
C UBT.</description><issn>0300-0605</issn><issn>1473-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNptUEtOwzAUtBBIlMIFWL0LBOzY-a0QBEorVUJCZR058XNrCHFlG1DuxuFI2i6QYPNGmpk3Iw0hl4xeMZZl10xkPOaU0oTyAVIqjshkJKORPSYTOkA08MkpOfP-lVIRp0k8Id8LD2GD8Izv0r3JukUobRecVKYJxnZQY_hC7GBufLCtXfcgOwVMQAkvDiXcDSdsYIU-gOl2WfcYcP9sNcyxNY2tZRPQwbZvrTOgPhCChZlsPUYdrmUwn_irwbqDtrXe7LR_-27OyYkefRcHnJLV7GFVzqPl0-OivF1GTRGLSCilkiKjWBdJzhE107rQPGWMyiTXQuSSC6YapZiShdJcyBSbhGnMckFVzack3sc2znrvUFdbZ4a5-orRapy_-js__wHNRXoU</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Gurbuz, AK</creator><creator>Ozel, AM</creator><creator>Narin, Y</creator><creator>Yazgan, Y</creator><creator>Baloglu, H</creator><creator>Demirturk, L</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200511</creationdate><title>Is the Remarkable Contradiction between Histology and 14 C Urea Breath Test in the Detection of Helicobacter pylori due to False-negative Histology or False-positive 14 C Urea Breath Test?</title><author>Gurbuz, AK ; Ozel, AM ; Narin, Y ; Yazgan, Y ; Baloglu, H ; Demirturk, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c924-4ddd5970eb9583eef1ff9f36110a58f448a341dcdd1da9df34a6ec51fe7840db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gurbuz, AK</creatorcontrib><creatorcontrib>Ozel, AM</creatorcontrib><creatorcontrib>Narin, Y</creatorcontrib><creatorcontrib>Yazgan, Y</creatorcontrib><creatorcontrib>Baloglu, H</creatorcontrib><creatorcontrib>Demirturk, L</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of international medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gurbuz, AK</au><au>Ozel, AM</au><au>Narin, Y</au><au>Yazgan, Y</au><au>Baloglu, H</au><au>Demirturk, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is the Remarkable Contradiction between Histology and 14 C Urea Breath Test in the Detection of Helicobacter pylori due to False-negative Histology or False-positive 14 C Urea Breath Test?</atitle><jtitle>Journal of international medical research</jtitle><date>2005-11</date><risdate>2005</risdate><volume>33</volume><issue>6</issue><spage>632</spage><epage>640</epage><pages>632-640</pages><issn>0300-0605</issn><eissn>1473-2300</eissn><abstract>We assessed the diagnostic value of the
14
C urea breath test (UBT) in the detection of Helicobacter pylori compared with histology and the rapid urease test (RUT). The study included 68 patients (22 men and 46 women) with dyspeptic symptoms. H. pylori status was evaluated by
14
C UBT, RUT and histology. Sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy were determined for
14
C UBT and for RUT. Histology revealed dense yeast-like micro-organisms in the biopsy specimens in all patients with false-positive results by
14
C UBT (n = 8), a significantly higher proportion than in patients with negative
14
C UBT (five of 31). The low specificity of the H. pylori
14
C UBT should not be neglected by accepting histology results as false-negative. Gastric mucosal colonization by yeast-like micro-organisms with urease activity can account for the high frequency of false-positive results for
14
C UBT.</abstract><doi>10.1177/147323000503300604</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-0605 |
| ispartof | Journal of international medical research, 2005-11, Vol.33 (6), p.632-640 |
| issn | 0300-0605 1473-2300 |
| language | eng |
| recordid | cdi_crossref_primary_10_1177_147323000503300604 |
| source | Sage Journals GOLD Open Access 2024; Alma/SFX Local Collection |
| title | Is the Remarkable Contradiction between Histology and 14 C Urea Breath Test in the Detection of Helicobacter pylori due to False-negative Histology or False-positive 14 C Urea Breath Test? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T21%3A27%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Is%20the%20Remarkable%20Contradiction%20between%20Histology%20and%2014%20C%20Urea%20Breath%20Test%20in%20the%20Detection%20of%20Helicobacter%20pylori%20due%20to%20False-negative%20Histology%20or%20False-positive%2014%20C%20Urea%20Breath%20Test?&rft.jtitle=Journal%20of%20international%20medical%20research&rft.au=Gurbuz,%20AK&rft.date=2005-11&rft.volume=33&rft.issue=6&rft.spage=632&rft.epage=640&rft.pages=632-640&rft.issn=0300-0605&rft.eissn=1473-2300&rft_id=info:doi/10.1177/147323000503300604&rft_dat=%3Ccrossref%3E10_1177_147323000503300604%3C/crossref%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |