Exploring mitochondrial nephrotoxicity as a potential mechanism of kidney dysfunction among HIV-infected patients on highly active antiretroviral therapy

Tenofovir (TDF) exposure has been associated with renal dysfunction. Mitochondrial nephrotoxicity was investigated as an underlying mechanism. Given the interaction between TDF and didanosine (ddl), their concurrent use was also investigated. Relative kidney biopsy mitochondrial DNA (mtDNA) to nucle...

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Veröffentlicht in:	Antiviral therapy 2006, Vol.11 (1), p.79-86
Hauptverfasser:	COTE, Hélène C. F, MAGIL, Alex B, HOGG, Robert, HARRIGAN, P. Richard, MONTANER, Julio S, HARRIS, Marianne, SCARTH, Brian J, GADAWSKI, Izabelle, WANG, Nancy, YU, Eugenia, YIP, Benita, ZALUNARDO, Nadia, WERB, Ron
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - administration & dosage Adenine - adverse effects Adenine - analogs & derivatives Adult Aged Aged, 80 and over Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active - adverse effects Antiviral agents Biological and medical sciences Biopsy Didanosine - administration & dosage Didanosine - adverse effects DNA, Mitochondrial - metabolism DNA, Mitochondrial - ultrastructure Drug Therapy, Combination Female HIV Infections - drug therapy HIV Infections - pathology Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Kidney - drug effects Kidney - metabolism Kidney - pathology Male Medical sciences Microscopy, Electron Middle Aged Mitochondria - drug effects Mitochondria - ultrastructure Organophosphonates - administration & dosage Organophosphonates - adverse effects Pharmacology. Drug treatments Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - adverse effects Tenofovir Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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