Effects of zidovudine, stavudine and β-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting

Although mitochondrial DNA (mtDNA) depletion could play a role in nucleoside reverse transcriptase inhibitor-induced lipoatrophy, poor correlations between fat mtDNA levels and lipoatrophy suggest additional mechanism(s). Stavudine (d4T), zidovudine (AZT) and the thymine catabolite, beta-aminoisobut...

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Veröffentlicht in:	Antiviral therapy 2004-10, Vol.9 (5), p.801-810
Hauptverfasser:	MOISONNEUVE, Caroline, IGOUDJIL, Anissa, BEGRICHE, Karima, LETTERON, Philippe, GUIMONT, Marie-Christine, BASTIN, Jean, LAIGNEAU, Jean-Pierre, PESSAYRE, Dominique, FROMENTY, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoisobutyric Acids - adverse effects Aminoisobutyric Acids - blood Animals Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Body Weight Homeostasis Lipid Metabolism Lipodystrophy - chemically induced Male Medical sciences Mice Mice, Inbred C57BL Mice, Obese Pharmacology. Drug treatments Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - adverse effects Stavudine - administration & dosage Stavudine - adverse effects Thinness Zidovudine - administration & dosage Zidovudine - adverse effects
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