Efficacy and safety of twice-daily versus three-times daily saquinavir soft gelatin capsules as part of triple combination therapy for HIV-1 infection

The objective of this study was to determine whether a triple therapy regimen incorporating twice-daily saquinavir is as effective as a three-times daily regimen. This was an open-label, Phase III, multicentre, 48-week study involving 837 HIV-1-infected patients randomised to one of the following: s...

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Veröffentlicht in:	Antiviral therapy 2002-09, Vol.7 (3), p.199-209
Hauptverfasser:	WHEAT, L. Joseph, FARTHING, Charles, COHEN, Calvin, PIERONE, Gerald, LALEZARI, Jay, PILSON, Robert S, SIEMON-HRYCZYK, Peggy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Capsules - administration & dosage CD4 Lymphocyte Count Dose-Response Relationship, Drug Drug Administration Schedule Drug Therapy, Combination Female HIV Infections - blood HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - adverse effects HIV Protease Inhibitors - therapeutic use HIV-1 - genetics HIV-1 - immunology HIV-1 - isolation & purification Humans Lipids - blood Male Medical sciences Middle Aged Patient Compliance Pharmacology. Drug treatments RNA, Viral - blood Saquinavir - administration & dosage Saquinavir - adverse effects Saquinavir - therapeutic use
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