New insights in the pathogenic mechanism of multiple sclerosis: Is Epstein-Barr virus associated with optic nerve involvement?
Introduction There are no reports in the literature studying the possible relationship between Epstein-Barr virus (EBV) and optic nerve involvement in multiple sclerosis (MS). The aim of our study was to analyze the association between EBV antibodies titres and optical coherence tomography (OCT) and...
Gespeichert in:
| Veröffentlicht in: | European journal of ophthalmology 2024-11, Vol.34 (6), p.2045-2052 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2052 |
|---|---|
| container_issue | 6 |
| container_start_page | 2045 |
| container_title | European journal of ophthalmology |
| container_volume | 34 |
| creator | Remolí-Sargues, Lidia Monferrer-Adsuara, Clara López-Salvador, Belén García-Villanueva, Carolina Gracia-García, Alicia Castro-Navarro, Verónica Cervera-Taulet, Enrique |
| description | Introduction
There are no reports in the literature studying the possible relationship between Epstein-Barr virus (EBV) and optic nerve involvement in multiple sclerosis (MS). The aim of our study was to analyze the association between EBV antibodies titres and optical coherence tomography (OCT) and OCT angiography (OCTA) quantitative parameters
Methods
We conducted a retrospective study. The study included 98 eyes of 49 patients with MS. Years of MS duration, relapse count, history of optic neuritis (ON), and immunoglobulin (Ig) G antibodies to the EBV viral capsid antigen (VCA) were recorded from each patient. Also, OCT analysis (including retinal nerve fibre layer (RNFL) thickness and ganglion cell-inner plexiform layer (GCIPL) thickness) and OCTA analysis (including perfusion density (PD) and flux index (FI) of the radial peripapillary capillary plexus) were performed in each participant.
Results
No significant associations were observed between anti-EBV antibody levels and OCT or OCTA parameters (p > 0,05). Correlation analysis between OCT and OCTA measurements showed a significant positive correlation between RNFL thickness and GCIPL thickness with peripapillary PD and FI (p |
| doi_str_mv | 10.1177/11206721241230567 |
| format | Article |
| fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1177_11206721241230567</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_11206721241230567</sage_id><sourcerecordid>10.1177_11206721241230567</sourcerecordid><originalsourceid>FETCH-LOGICAL-c292t-4ee649b90fb88419108666ea806735a1f9702152b21d96c7df384f46a829f8463</originalsourceid><addsrcrecordid>eNp9UMtOwzAQtBCIQuEDuCD_QIrXcR2HC4KqQKUKLnCO3HTTuMpLtpOKC9-OqwIXJE470s7M7gwhV8AmAElyA8CZTDhwATxmU5kckTNIuIgkA3kccNhHe8KInDu3ZYyzVPBTMopVDKBUckY-X3BHTePMpvQuAOpLpJ32ZbvBxuS0xrzUjXE1bQta95U3XYXU5RXa1hl3SxeOzjvn0TTRg7aWDsb2jmrn2txoj2u6M76kbeeDWYN2wHBkaKsBa2z83QU5KXTl8PJ7jsn74_xt9hwtX58Ws_tllPOU-0ggSpGuUlaslBKQAlNSStQqxI-nGoo0YRymfMVhnco8WRexEoWQWvG0UELGYwIH3zy87SwWWWdNre1HBizbd5n96TJorg-arl_VuP5V_JQXCJMDwekNZtu2t03I8I_jF7wBfQ8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>New insights in the pathogenic mechanism of multiple sclerosis: Is Epstein-Barr virus associated with optic nerve involvement?</title><source>Access via SAGE</source><source>MEDLINE</source><creator>Remolí-Sargues, Lidia ; Monferrer-Adsuara, Clara ; López-Salvador, Belén ; García-Villanueva, Carolina ; Gracia-García, Alicia ; Castro-Navarro, Verónica ; Cervera-Taulet, Enrique</creator><creatorcontrib>Remolí-Sargues, Lidia ; Monferrer-Adsuara, Clara ; López-Salvador, Belén ; García-Villanueva, Carolina ; Gracia-García, Alicia ; Castro-Navarro, Verónica ; Cervera-Taulet, Enrique</creatorcontrib><description>Introduction
There are no reports in the literature studying the possible relationship between Epstein-Barr virus (EBV) and optic nerve involvement in multiple sclerosis (MS). The aim of our study was to analyze the association between EBV antibodies titres and optical coherence tomography (OCT) and OCT angiography (OCTA) quantitative parameters
Methods
We conducted a retrospective study. The study included 98 eyes of 49 patients with MS. Years of MS duration, relapse count, history of optic neuritis (ON), and immunoglobulin (Ig) G antibodies to the EBV viral capsid antigen (VCA) were recorded from each patient. Also, OCT analysis (including retinal nerve fibre layer (RNFL) thickness and ganglion cell-inner plexiform layer (GCIPL) thickness) and OCTA analysis (including perfusion density (PD) and flux index (FI) of the radial peripapillary capillary plexus) were performed in each participant.
Results
No significant associations were observed between anti-EBV antibody levels and OCT or OCTA parameters (p > 0,05). Correlation analysis between OCT and OCTA measurements showed a significant positive correlation between RNFL thickness and GCIPL thickness with peripapillary PD and FI (p < 0,035). Subgroup analysis revealed a significant diminution of RNFL thickness, GCIPL thickness and peripapillary PD and FI (p < 0,05) in the ON group.
Conclusion
We were unable to demonstrate a significant association between anti-EBV VCA IgG antibody titres and OCT or OCTA parameters. Nonetheless, further longitudinal studies are needed to explore the possible association of EBV with optic nerve involvement in MS.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.1177/11206721241230567</identifier><identifier>PMID: 38311887</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Antibodies, Viral - blood ; Antigens, Viral ; Capsid Proteins - immunology ; Epstein-Barr Virus Infections - complications ; Epstein-Barr Virus Infections - diagnosis ; Epstein-Barr Virus Infections - virology ; Eye Infections, Viral - diagnosis ; Eye Infections, Viral - virology ; Female ; Fluorescein Angiography - methods ; Herpesvirus 4, Human - immunology ; Herpesvirus 4, Human - isolation & purification ; Humans ; Immunoglobulin G - blood ; Male ; Middle Aged ; Multiple Sclerosis - diagnosis ; Multiple Sclerosis - virology ; Nerve Fibers - pathology ; Optic Nerve - diagnostic imaging ; Optic Nerve - pathology ; Optic Nerve - virology ; Optic Neuritis - diagnosis ; Optic Neuritis - immunology ; Optic Neuritis - virology ; Retinal Ganglion Cells - pathology ; Retinal Ganglion Cells - virology ; Retrospective Studies ; Tomography, Optical Coherence ; Young Adult</subject><ispartof>European journal of ophthalmology, 2024-11, Vol.34 (6), p.2045-2052</ispartof><rights>The Author(s) 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c292t-4ee649b90fb88419108666ea806735a1f9702152b21d96c7df384f46a829f8463</cites><orcidid>0000-0003-0399-0903 ; 0000-0002-7919-0462</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/11206721241230567$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/11206721241230567$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21824,27929,27930,43626,43627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38311887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Remolí-Sargues, Lidia</creatorcontrib><creatorcontrib>Monferrer-Adsuara, Clara</creatorcontrib><creatorcontrib>López-Salvador, Belén</creatorcontrib><creatorcontrib>García-Villanueva, Carolina</creatorcontrib><creatorcontrib>Gracia-García, Alicia</creatorcontrib><creatorcontrib>Castro-Navarro, Verónica</creatorcontrib><creatorcontrib>Cervera-Taulet, Enrique</creatorcontrib><title>New insights in the pathogenic mechanism of multiple sclerosis: Is Epstein-Barr virus associated with optic nerve involvement?</title><title>European journal of ophthalmology</title><addtitle>Eur J Ophthalmol</addtitle><description>Introduction
There are no reports in the literature studying the possible relationship between Epstein-Barr virus (EBV) and optic nerve involvement in multiple sclerosis (MS). The aim of our study was to analyze the association between EBV antibodies titres and optical coherence tomography (OCT) and OCT angiography (OCTA) quantitative parameters
Methods
We conducted a retrospective study. The study included 98 eyes of 49 patients with MS. Years of MS duration, relapse count, history of optic neuritis (ON), and immunoglobulin (Ig) G antibodies to the EBV viral capsid antigen (VCA) were recorded from each patient. Also, OCT analysis (including retinal nerve fibre layer (RNFL) thickness and ganglion cell-inner plexiform layer (GCIPL) thickness) and OCTA analysis (including perfusion density (PD) and flux index (FI) of the radial peripapillary capillary plexus) were performed in each participant.
Results
No significant associations were observed between anti-EBV antibody levels and OCT or OCTA parameters (p > 0,05). Correlation analysis between OCT and OCTA measurements showed a significant positive correlation between RNFL thickness and GCIPL thickness with peripapillary PD and FI (p < 0,035). Subgroup analysis revealed a significant diminution of RNFL thickness, GCIPL thickness and peripapillary PD and FI (p < 0,05) in the ON group.
Conclusion
We were unable to demonstrate a significant association between anti-EBV VCA IgG antibody titres and OCT or OCTA parameters. Nonetheless, further longitudinal studies are needed to explore the possible association of EBV with optic nerve involvement in MS.</description><subject>Adult</subject><subject>Antibodies, Viral - blood</subject><subject>Antigens, Viral</subject><subject>Capsid Proteins - immunology</subject><subject>Epstein-Barr Virus Infections - complications</subject><subject>Epstein-Barr Virus Infections - diagnosis</subject><subject>Epstein-Barr Virus Infections - virology</subject><subject>Eye Infections, Viral - diagnosis</subject><subject>Eye Infections, Viral - virology</subject><subject>Female</subject><subject>Fluorescein Angiography - methods</subject><subject>Herpesvirus 4, Human - immunology</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Multiple Sclerosis - virology</subject><subject>Nerve Fibers - pathology</subject><subject>Optic Nerve - diagnostic imaging</subject><subject>Optic Nerve - pathology</subject><subject>Optic Nerve - virology</subject><subject>Optic Neuritis - diagnosis</subject><subject>Optic Neuritis - immunology</subject><subject>Optic Neuritis - virology</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Retinal Ganglion Cells - virology</subject><subject>Retrospective Studies</subject><subject>Tomography, Optical Coherence</subject><subject>Young Adult</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UMtOwzAQtBCIQuEDuCD_QIrXcR2HC4KqQKUKLnCO3HTTuMpLtpOKC9-OqwIXJE470s7M7gwhV8AmAElyA8CZTDhwATxmU5kckTNIuIgkA3kccNhHe8KInDu3ZYyzVPBTMopVDKBUckY-X3BHTePMpvQuAOpLpJ32ZbvBxuS0xrzUjXE1bQta95U3XYXU5RXa1hl3SxeOzjvn0TTRg7aWDsb2jmrn2txoj2u6M76kbeeDWYN2wHBkaKsBa2z83QU5KXTl8PJ7jsn74_xt9hwtX58Ws_tllPOU-0ggSpGuUlaslBKQAlNSStQqxI-nGoo0YRymfMVhnco8WRexEoWQWvG0UELGYwIH3zy87SwWWWdNre1HBizbd5n96TJorg-arl_VuP5V_JQXCJMDwekNZtu2t03I8I_jF7wBfQ8</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Remolí-Sargues, Lidia</creator><creator>Monferrer-Adsuara, Clara</creator><creator>López-Salvador, Belén</creator><creator>García-Villanueva, Carolina</creator><creator>Gracia-García, Alicia</creator><creator>Castro-Navarro, Verónica</creator><creator>Cervera-Taulet, Enrique</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-0399-0903</orcidid><orcidid>https://orcid.org/0000-0002-7919-0462</orcidid></search><sort><creationdate>20241101</creationdate><title>New insights in the pathogenic mechanism of multiple sclerosis: Is Epstein-Barr virus associated with optic nerve involvement?</title><author>Remolí-Sargues, Lidia ; Monferrer-Adsuara, Clara ; López-Salvador, Belén ; García-Villanueva, Carolina ; Gracia-García, Alicia ; Castro-Navarro, Verónica ; Cervera-Taulet, Enrique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-4ee649b90fb88419108666ea806735a1f9702152b21d96c7df384f46a829f8463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Antibodies, Viral - blood</topic><topic>Antigens, Viral</topic><topic>Capsid Proteins - immunology</topic><topic>Epstein-Barr Virus Infections - complications</topic><topic>Epstein-Barr Virus Infections - diagnosis</topic><topic>Epstein-Barr Virus Infections - virology</topic><topic>Eye Infections, Viral - diagnosis</topic><topic>Eye Infections, Viral - virology</topic><topic>Female</topic><topic>Fluorescein Angiography - methods</topic><topic>Herpesvirus 4, Human - immunology</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple Sclerosis - virology</topic><topic>Nerve Fibers - pathology</topic><topic>Optic Nerve - diagnostic imaging</topic><topic>Optic Nerve - pathology</topic><topic>Optic Nerve - virology</topic><topic>Optic Neuritis - diagnosis</topic><topic>Optic Neuritis - immunology</topic><topic>Optic Neuritis - virology</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Retinal Ganglion Cells - virology</topic><topic>Retrospective Studies</topic><topic>Tomography, Optical Coherence</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Remolí-Sargues, Lidia</creatorcontrib><creatorcontrib>Monferrer-Adsuara, Clara</creatorcontrib><creatorcontrib>López-Salvador, Belén</creatorcontrib><creatorcontrib>García-Villanueva, Carolina</creatorcontrib><creatorcontrib>Gracia-García, Alicia</creatorcontrib><creatorcontrib>Castro-Navarro, Verónica</creatorcontrib><creatorcontrib>Cervera-Taulet, Enrique</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Remolí-Sargues, Lidia</au><au>Monferrer-Adsuara, Clara</au><au>López-Salvador, Belén</au><au>García-Villanueva, Carolina</au><au>Gracia-García, Alicia</au><au>Castro-Navarro, Verónica</au><au>Cervera-Taulet, Enrique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New insights in the pathogenic mechanism of multiple sclerosis: Is Epstein-Barr virus associated with optic nerve involvement?</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>Eur J Ophthalmol</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>34</volume><issue>6</issue><spage>2045</spage><epage>2052</epage><pages>2045-2052</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>Introduction
There are no reports in the literature studying the possible relationship between Epstein-Barr virus (EBV) and optic nerve involvement in multiple sclerosis (MS). The aim of our study was to analyze the association between EBV antibodies titres and optical coherence tomography (OCT) and OCT angiography (OCTA) quantitative parameters
Methods
We conducted a retrospective study. The study included 98 eyes of 49 patients with MS. Years of MS duration, relapse count, history of optic neuritis (ON), and immunoglobulin (Ig) G antibodies to the EBV viral capsid antigen (VCA) were recorded from each patient. Also, OCT analysis (including retinal nerve fibre layer (RNFL) thickness and ganglion cell-inner plexiform layer (GCIPL) thickness) and OCTA analysis (including perfusion density (PD) and flux index (FI) of the radial peripapillary capillary plexus) were performed in each participant.
Results
No significant associations were observed between anti-EBV antibody levels and OCT or OCTA parameters (p > 0,05). Correlation analysis between OCT and OCTA measurements showed a significant positive correlation between RNFL thickness and GCIPL thickness with peripapillary PD and FI (p < 0,035). Subgroup analysis revealed a significant diminution of RNFL thickness, GCIPL thickness and peripapillary PD and FI (p < 0,05) in the ON group.
Conclusion
We were unable to demonstrate a significant association between anti-EBV VCA IgG antibody titres and OCT or OCTA parameters. Nonetheless, further longitudinal studies are needed to explore the possible association of EBV with optic nerve involvement in MS.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>38311887</pmid><doi>10.1177/11206721241230567</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0399-0903</orcidid><orcidid>https://orcid.org/0000-0002-7919-0462</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1120-6721 |
| ispartof | European journal of ophthalmology, 2024-11, Vol.34 (6), p.2045-2052 |
| issn | 1120-6721 1724-6016 |
| language | eng |
| recordid | cdi_crossref_primary_10_1177_11206721241230567 |
| source | Access via SAGE; MEDLINE |
| subjects | Adult Antibodies, Viral - blood Antigens, Viral Capsid Proteins - immunology Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - diagnosis Epstein-Barr Virus Infections - virology Eye Infections, Viral - diagnosis Eye Infections, Viral - virology Female Fluorescein Angiography - methods Herpesvirus 4, Human - immunology Herpesvirus 4, Human - isolation & purification Humans Immunoglobulin G - blood Male Middle Aged Multiple Sclerosis - diagnosis Multiple Sclerosis - virology Nerve Fibers - pathology Optic Nerve - diagnostic imaging Optic Nerve - pathology Optic Nerve - virology Optic Neuritis - diagnosis Optic Neuritis - immunology Optic Neuritis - virology Retinal Ganglion Cells - pathology Retinal Ganglion Cells - virology Retrospective Studies Tomography, Optical Coherence Young Adult |
| title | New insights in the pathogenic mechanism of multiple sclerosis: Is Epstein-Barr virus associated with optic nerve involvement? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T07%3A31%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-sage_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20insights%20in%20the%20pathogenic%20mechanism%20of%20multiple%20sclerosis:%20Is%20Epstein-Barr%20virus%20associated%20with%20optic%20nerve%20involvement?&rft.jtitle=European%20journal%20of%20ophthalmology&rft.au=Remol%C3%AD-Sargues,%20Lidia&rft.date=2024-11-01&rft.volume=34&rft.issue=6&rft.spage=2045&rft.epage=2052&rft.pages=2045-2052&rft.issn=1120-6721&rft.eissn=1724-6016&rft_id=info:doi/10.1177/11206721241230567&rft_dat=%3Csage_cross%3E10.1177_11206721241230567%3C/sage_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/38311887&rft_sage_id=10.1177_11206721241230567&rfr_iscdi=true |