Do intravitreal anti-VEGF injections have an effect on corneal endothelial remodeling in children with premature retinopathy?
Purpose This study was carried out to investigate the effects of retinopathy of prematurity (ROP) and intravitreal antivascular endothelial growth factor (VEGF) injections on the corneal endothelium in the childhood period of patients who have had ROP. Methods The material of comparative case-contro...
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| Veröffentlicht in: | European journal of ophthalmology 2024-09, Vol.34 (5), p.1393-1399 |
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| container_title | European journal of ophthalmology |
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| creator | Yavuz, Sibel Kazım Erol, Muhammet Küçük, Mehmet Fatih Süren, Elçin Doğan, Berna Deniz İlhan, Hatice Sabancı, Şenol Yaprak, Lütfiye Gedik, Birumut Türkmen, Berkay Duman, Fulya |
| description | Purpose
This study was carried out to investigate the effects of retinopathy of prematurity (ROP) and intravitreal antivascular endothelial growth factor (VEGF) injections on the corneal endothelium in the childhood period of patients who have had ROP.
Methods
The material of comparative case-control clinical study consisted of patients followed up with ROP between February 2013 and February 2023. The eyes in the study group were divided into two subgroups consisting of those who received intravitreal anti-VEGF injections (subgroup 1) and those who were followed up only (subgroup 2). Central corneal endothelial cell density (ECD), coefficient of variation (CV), central corneal thickness (CCT), and pleomorphism parameters in the childhood period were evaluated by corneal specular microscopy and compared with age-matched healthy control subjects.
Results
There were 84 eyes of 42 patients with ROP in the study group and 80 eyes of 40 healthy children in the control group. Mean CCT was significantly higher in subgroup 1 and the control group than in subgroup 2 (p = 0.037), and mean ECD was significantly higher in subgroup 2 than in subgroup 1 and the control group (p |
| doi_str_mv | 10.1177/11206721241229320 |
| format | Article |
| fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1177_11206721241229320</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_11206721241229320</sage_id><sourcerecordid>10.1177_11206721241229320</sourcerecordid><originalsourceid>FETCH-LOGICAL-c292t-885d8d4b5aaf562644fff8b9fa3d130d2e052efe1ef3cc6caafa352f101eebd13</originalsourceid><addsrcrecordid>eNp9kM1KAzEUhYMoVqsP4EbyAlPzM78rkdpWoeBG3Q6Z5KaTMk2GTFrpwnc3pepGcHUP93znwj0I3VAyobQo7ihlJC8YZSllrOKMnKALWrA0yQnNT6OOfnIARuhyGNaEMFKl7ByNeMkJz1JygT4fHTY2eLEzwYPosLDBJO-zxTyu1yCDcXbArdhBdDBoHVfYWSydtwccrHKhhc5E7WHjVJR2FbNYtqZTHiz-MKHFfTRF2HqIVDDW9SK0-_srdKZFN8D19xyjt_nsdfqULF8Wz9OHZSJZxUJSlpkqVdpkQugsZ3maaq3LptKCK8qJYkAyBhooaC5lLiMmeMY0JRSgicgY0eNd6d0weNB1781G-H1NSX2osv5TZczcHjP9ttmA-k38dBeByREYxArqtdt6G3_45-IXXPF-8g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Do intravitreal anti-VEGF injections have an effect on corneal endothelial remodeling in children with premature retinopathy?</title><source>Access via SAGE</source><source>MEDLINE</source><creator>Yavuz, Sibel ; Kazım Erol, Muhammet ; Küçük, Mehmet Fatih ; Süren, Elçin ; Doğan, Berna ; Deniz İlhan, Hatice ; Sabancı, Şenol ; Yaprak, Lütfiye ; Gedik, Birumut ; Türkmen, Berkay ; Duman, Fulya</creator><creatorcontrib>Yavuz, Sibel ; Kazım Erol, Muhammet ; Küçük, Mehmet Fatih ; Süren, Elçin ; Doğan, Berna ; Deniz İlhan, Hatice ; Sabancı, Şenol ; Yaprak, Lütfiye ; Gedik, Birumut ; Türkmen, Berkay ; Duman, Fulya</creatorcontrib><description>Purpose
This study was carried out to investigate the effects of retinopathy of prematurity (ROP) and intravitreal antivascular endothelial growth factor (VEGF) injections on the corneal endothelium in the childhood period of patients who have had ROP.
Methods
The material of comparative case-control clinical study consisted of patients followed up with ROP between February 2013 and February 2023. The eyes in the study group were divided into two subgroups consisting of those who received intravitreal anti-VEGF injections (subgroup 1) and those who were followed up only (subgroup 2). Central corneal endothelial cell density (ECD), coefficient of variation (CV), central corneal thickness (CCT), and pleomorphism parameters in the childhood period were evaluated by corneal specular microscopy and compared with age-matched healthy control subjects.
Results
There were 84 eyes of 42 patients with ROP in the study group and 80 eyes of 40 healthy children in the control group. Mean CCT was significantly higher in subgroup 1 and the control group than in subgroup 2 (p = 0.037), and mean ECD was significantly higher in subgroup 2 than in subgroup 1 and the control group (p < 0.001). There was no significant difference between subgroup 1 and the control group in mean ECD and CCT values (p = 1.000 for both cases).
Conclusions
Considering that ROP patients who received intravitreal anti-VEGF injections had more advanced-stage ROP than ROP patients who were followed up only, these findings suggest that intravitreal anti-VEGF applications in ROP cases may lead to corneal endothelial parameters similar to those of healthy eyes.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.1177/11206721241229320</identifier><identifier>PMID: 38303540</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Angiogenesis Inhibitors - administration & dosage ; Angiogenesis Inhibitors - therapeutic use ; Bevacizumab - administration & dosage ; Bevacizumab - therapeutic use ; Case-Control Studies ; Cell Count ; Child ; Child, Preschool ; Endothelium, Corneal - pathology ; Female ; Follow-Up Studies ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Intravitreal Injections ; Male ; Ranibizumab - administration & dosage ; Ranibizumab - therapeutic use ; Retinopathy of Prematurity - diagnosis ; Retinopathy of Prematurity - drug therapy ; Retinopathy of Prematurity - physiopathology ; Vascular Endothelial Growth Factor A - antagonists & inhibitors</subject><ispartof>European journal of ophthalmology, 2024-09, Vol.34 (5), p.1393-1399</ispartof><rights>The Author(s) 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c292t-885d8d4b5aaf562644fff8b9fa3d130d2e052efe1ef3cc6caafa352f101eebd13</cites><orcidid>0000-0002-9087-7644</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/11206721241229320$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/11206721241229320$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38303540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yavuz, Sibel</creatorcontrib><creatorcontrib>Kazım Erol, Muhammet</creatorcontrib><creatorcontrib>Küçük, Mehmet Fatih</creatorcontrib><creatorcontrib>Süren, Elçin</creatorcontrib><creatorcontrib>Doğan, Berna</creatorcontrib><creatorcontrib>Deniz İlhan, Hatice</creatorcontrib><creatorcontrib>Sabancı, Şenol</creatorcontrib><creatorcontrib>Yaprak, Lütfiye</creatorcontrib><creatorcontrib>Gedik, Birumut</creatorcontrib><creatorcontrib>Türkmen, Berkay</creatorcontrib><creatorcontrib>Duman, Fulya</creatorcontrib><title>Do intravitreal anti-VEGF injections have an effect on corneal endothelial remodeling in children with premature retinopathy?</title><title>European journal of ophthalmology</title><addtitle>Eur J Ophthalmol</addtitle><description>Purpose
This study was carried out to investigate the effects of retinopathy of prematurity (ROP) and intravitreal antivascular endothelial growth factor (VEGF) injections on the corneal endothelium in the childhood period of patients who have had ROP.
Methods
The material of comparative case-control clinical study consisted of patients followed up with ROP between February 2013 and February 2023. The eyes in the study group were divided into two subgroups consisting of those who received intravitreal anti-VEGF injections (subgroup 1) and those who were followed up only (subgroup 2). Central corneal endothelial cell density (ECD), coefficient of variation (CV), central corneal thickness (CCT), and pleomorphism parameters in the childhood period were evaluated by corneal specular microscopy and compared with age-matched healthy control subjects.
Results
There were 84 eyes of 42 patients with ROP in the study group and 80 eyes of 40 healthy children in the control group. Mean CCT was significantly higher in subgroup 1 and the control group than in subgroup 2 (p = 0.037), and mean ECD was significantly higher in subgroup 2 than in subgroup 1 and the control group (p < 0.001). There was no significant difference between subgroup 1 and the control group in mean ECD and CCT values (p = 1.000 for both cases).
Conclusions
Considering that ROP patients who received intravitreal anti-VEGF injections had more advanced-stage ROP than ROP patients who were followed up only, these findings suggest that intravitreal anti-VEGF applications in ROP cases may lead to corneal endothelial parameters similar to those of healthy eyes.</description><subject>Angiogenesis Inhibitors - administration & dosage</subject><subject>Angiogenesis Inhibitors - therapeutic use</subject><subject>Bevacizumab - administration & dosage</subject><subject>Bevacizumab - therapeutic use</subject><subject>Case-Control Studies</subject><subject>Cell Count</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Endothelium, Corneal - pathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Intravitreal Injections</subject><subject>Male</subject><subject>Ranibizumab - administration & dosage</subject><subject>Ranibizumab - therapeutic use</subject><subject>Retinopathy of Prematurity - diagnosis</subject><subject>Retinopathy of Prematurity - drug therapy</subject><subject>Retinopathy of Prematurity - physiopathology</subject><subject>Vascular Endothelial Growth Factor A - antagonists & inhibitors</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KAzEUhYMoVqsP4EbyAlPzM78rkdpWoeBG3Q6Z5KaTMk2GTFrpwnc3pepGcHUP93znwj0I3VAyobQo7ihlJC8YZSllrOKMnKALWrA0yQnNT6OOfnIARuhyGNaEMFKl7ByNeMkJz1JygT4fHTY2eLEzwYPosLDBJO-zxTyu1yCDcXbArdhBdDBoHVfYWSydtwccrHKhhc5E7WHjVJR2FbNYtqZTHiz-MKHFfTRF2HqIVDDW9SK0-_srdKZFN8D19xyjt_nsdfqULF8Wz9OHZSJZxUJSlpkqVdpkQugsZ3maaq3LptKCK8qJYkAyBhooaC5lLiMmeMY0JRSgicgY0eNd6d0weNB1781G-H1NSX2osv5TZczcHjP9ttmA-k38dBeByREYxArqtdt6G3_45-IXXPF-8g</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Yavuz, Sibel</creator><creator>Kazım Erol, Muhammet</creator><creator>Küçük, Mehmet Fatih</creator><creator>Süren, Elçin</creator><creator>Doğan, Berna</creator><creator>Deniz İlhan, Hatice</creator><creator>Sabancı, Şenol</creator><creator>Yaprak, Lütfiye</creator><creator>Gedik, Birumut</creator><creator>Türkmen, Berkay</creator><creator>Duman, Fulya</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-9087-7644</orcidid></search><sort><creationdate>20240901</creationdate><title>Do intravitreal anti-VEGF injections have an effect on corneal endothelial remodeling in children with premature retinopathy?</title><author>Yavuz, Sibel ; Kazım Erol, Muhammet ; Küçük, Mehmet Fatih ; Süren, Elçin ; Doğan, Berna ; Deniz İlhan, Hatice ; Sabancı, Şenol ; Yaprak, Lütfiye ; Gedik, Birumut ; Türkmen, Berkay ; Duman, Fulya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-885d8d4b5aaf562644fff8b9fa3d130d2e052efe1ef3cc6caafa352f101eebd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Angiogenesis Inhibitors - administration & dosage</topic><topic>Angiogenesis Inhibitors - therapeutic use</topic><topic>Bevacizumab - administration & dosage</topic><topic>Bevacizumab - therapeutic use</topic><topic>Case-Control Studies</topic><topic>Cell Count</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Endothelium, Corneal - pathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Intravitreal Injections</topic><topic>Male</topic><topic>Ranibizumab - administration & dosage</topic><topic>Ranibizumab - therapeutic use</topic><topic>Retinopathy of Prematurity - diagnosis</topic><topic>Retinopathy of Prematurity - drug therapy</topic><topic>Retinopathy of Prematurity - physiopathology</topic><topic>Vascular Endothelial Growth Factor A - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yavuz, Sibel</creatorcontrib><creatorcontrib>Kazım Erol, Muhammet</creatorcontrib><creatorcontrib>Küçük, Mehmet Fatih</creatorcontrib><creatorcontrib>Süren, Elçin</creatorcontrib><creatorcontrib>Doğan, Berna</creatorcontrib><creatorcontrib>Deniz İlhan, Hatice</creatorcontrib><creatorcontrib>Sabancı, Şenol</creatorcontrib><creatorcontrib>Yaprak, Lütfiye</creatorcontrib><creatorcontrib>Gedik, Birumut</creatorcontrib><creatorcontrib>Türkmen, Berkay</creatorcontrib><creatorcontrib>Duman, Fulya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yavuz, Sibel</au><au>Kazım Erol, Muhammet</au><au>Küçük, Mehmet Fatih</au><au>Süren, Elçin</au><au>Doğan, Berna</au><au>Deniz İlhan, Hatice</au><au>Sabancı, Şenol</au><au>Yaprak, Lütfiye</au><au>Gedik, Birumut</au><au>Türkmen, Berkay</au><au>Duman, Fulya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do intravitreal anti-VEGF injections have an effect on corneal endothelial remodeling in children with premature retinopathy?</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>Eur J Ophthalmol</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>34</volume><issue>5</issue><spage>1393</spage><epage>1399</epage><pages>1393-1399</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>Purpose
This study was carried out to investigate the effects of retinopathy of prematurity (ROP) and intravitreal antivascular endothelial growth factor (VEGF) injections on the corneal endothelium in the childhood period of patients who have had ROP.
Methods
The material of comparative case-control clinical study consisted of patients followed up with ROP between February 2013 and February 2023. The eyes in the study group were divided into two subgroups consisting of those who received intravitreal anti-VEGF injections (subgroup 1) and those who were followed up only (subgroup 2). Central corneal endothelial cell density (ECD), coefficient of variation (CV), central corneal thickness (CCT), and pleomorphism parameters in the childhood period were evaluated by corneal specular microscopy and compared with age-matched healthy control subjects.
Results
There were 84 eyes of 42 patients with ROP in the study group and 80 eyes of 40 healthy children in the control group. Mean CCT was significantly higher in subgroup 1 and the control group than in subgroup 2 (p = 0.037), and mean ECD was significantly higher in subgroup 2 than in subgroup 1 and the control group (p < 0.001). There was no significant difference between subgroup 1 and the control group in mean ECD and CCT values (p = 1.000 for both cases).
Conclusions
Considering that ROP patients who received intravitreal anti-VEGF injections had more advanced-stage ROP than ROP patients who were followed up only, these findings suggest that intravitreal anti-VEGF applications in ROP cases may lead to corneal endothelial parameters similar to those of healthy eyes.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>38303540</pmid><doi>10.1177/11206721241229320</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9087-7644</orcidid></addata></record> |
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| ispartof | European journal of ophthalmology, 2024-09, Vol.34 (5), p.1393-1399 |
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| subjects | Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - therapeutic use Bevacizumab - administration & dosage Bevacizumab - therapeutic use Case-Control Studies Cell Count Child Child, Preschool Endothelium, Corneal - pathology Female Follow-Up Studies Gestational Age Humans Infant Infant, Newborn Intravitreal Injections Male Ranibizumab - administration & dosage Ranibizumab - therapeutic use Retinopathy of Prematurity - diagnosis Retinopathy of Prematurity - drug therapy Retinopathy of Prematurity - physiopathology Vascular Endothelial Growth Factor A - antagonists & inhibitors |
| title | Do intravitreal anti-VEGF injections have an effect on corneal endothelial remodeling in children with premature retinopathy? |
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