Liposomal ozonated oil effectiveness in the signs and symptoms of blepharitis in usual clinical practice
Purpose To analyze the efficacy of liposomal ozonated oil (Ozonest®) treatment, in patients with blepharitis or blepharoconjunctivitis, in improving the signs and symptoms of the pathology. Methods Exploratory, open-label, prospective, single-arm, pre-post comparative pilot study in usual clinical p...
Gespeichert in:
| Veröffentlicht in: | European journal of ophthalmology 2024-05, Vol.34 (3), p.678-682 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 682 |
|---|---|
| container_issue | 3 |
| container_start_page | 678 |
| container_title | European journal of ophthalmology |
| container_volume | 34 |
| creator | Benítez-Del-Castillo, Jose Manuel |
| description | Purpose
To analyze the efficacy of liposomal ozonated oil (Ozonest®) treatment, in patients with blepharitis or blepharoconjunctivitis, in improving the signs and symptoms of the pathology.
Methods
Exploratory, open-label, prospective, single-arm, pre-post comparative pilot study in usual clinical practice, in 20 patients with blepharitis/blepharoconjunctivitis, receiving treatment with liposomal ozonated oil, one drop in each eye, 4 times a day, for 28 days. Main purpose was to assess whether there was a clinically improvement in the blepharitis specific BLISS questionnaire score. Changes in the 12-item OSDI, in eyelid signs of blepharitis assessed by the physicians were also evaluated among other tests, and there was also a subjective evaluation of the treatment by patients.
Results
The BLISS score significantly improved from 16.4 before treatment to 11.8 after treatment (p |
| doi_str_mv | 10.1177/11206721231207116 |
| format | Article |
| fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1177_11206721231207116</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_11206721231207116</sage_id><sourcerecordid>10.1177_11206721231207116</sourcerecordid><originalsourceid>FETCH-LOGICAL-c292t-fd63a2a71126c0f308e4c998749ceed7574f6e79f156d9bf89edb13a470f06ab3</originalsourceid><addsrcrecordid>eNp9kF9LwzAUxYMobk4_gC-SL9CZpFnSPMrwHxR80eeSJjdbRtuUphXmpzdz6ovg0z1czvnBOQhdU7KkVMpbShkRklGWJyEpFSdoTiXjmSBUnCad3tnBMEMXMe4IYURxdo5muSw4F4TM0bb0fYih1Q0OH6HTI1gcfIPBOTCjf4cOYsS-w-MWcPSbLmLdWRz3bT-GNuLgcN1Av9WDH_2XcYpTgpnGd94k0Q86cQxcojOnmwhX33eB3h7uX9dPWfny-Ly-KzPDFBszZ0WumU5lmDDE5aQAbpQqJFcGwMqV5E6AVI6uhFW1KxTYmuaaS-KI0HW-QPTINUOIcQBX9YNv9bCvKKkOq1V_VkuZm2Omn-oW7G_iZ6ZkWB4NUW-g2oVp6FKHf4ifVHd2XA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Liposomal ozonated oil effectiveness in the signs and symptoms of blepharitis in usual clinical practice</title><source>MEDLINE</source><source>SAGE Complete</source><creator>Benítez-Del-Castillo, Jose Manuel</creator><creatorcontrib>Benítez-Del-Castillo, Jose Manuel</creatorcontrib><description>Purpose
To analyze the efficacy of liposomal ozonated oil (Ozonest®) treatment, in patients with blepharitis or blepharoconjunctivitis, in improving the signs and symptoms of the pathology.
Methods
Exploratory, open-label, prospective, single-arm, pre-post comparative pilot study in usual clinical practice, in 20 patients with blepharitis/blepharoconjunctivitis, receiving treatment with liposomal ozonated oil, one drop in each eye, 4 times a day, for 28 days. Main purpose was to assess whether there was a clinically improvement in the blepharitis specific BLISS questionnaire score. Changes in the 12-item OSDI, in eyelid signs of blepharitis assessed by the physicians were also evaluated among other tests, and there was also a subjective evaluation of the treatment by patients.
Results
The BLISS score significantly improved from 16.4 before treatment to 11.8 after treatment (p < 0.05). The OSDI score was also significantly improved from 27.5 before treatment to 20.5 after treatment (p < 0.05). All tests conducted before and after treatment showed significant improvement (p < 0.05), except for NIBUT. The treatment received a score of 7 out of 10 by the patients. There were no adverse events in any patient.
Conclusion
Liposomal ozonated oil treatment showed good efficacy in improving the signs and symptoms of blepharitis/blepharoconjunctivitis, satisfaction of patients, and good safety and tolerability.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.1177/11206721231207116</identifier><identifier>PMID: 37844600</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anti-Infective Agents, Local - administration & dosage ; Anti-Infective Agents, Local - pharmacology ; Blepharitis - therapy ; Female ; Humans ; Liposomes ; Male ; Middle Aged ; Oils - administration & dosage ; Oils - pharmacology ; Ozone - administration & dosage ; Ozone - pharmacology ; Pilot Projects ; Prospective Studies ; Young Adult</subject><ispartof>European journal of ophthalmology, 2024-05, Vol.34 (3), p.678-682</ispartof><rights>The Author(s) 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c292t-fd63a2a71126c0f308e4c998749ceed7574f6e79f156d9bf89edb13a470f06ab3</cites><orcidid>0000-0002-2010-1701</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/11206721231207116$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/11206721231207116$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37844600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benítez-Del-Castillo, Jose Manuel</creatorcontrib><title>Liposomal ozonated oil effectiveness in the signs and symptoms of blepharitis in usual clinical practice</title><title>European journal of ophthalmology</title><addtitle>European Journal of Ophthalmology</addtitle><description>Purpose
To analyze the efficacy of liposomal ozonated oil (Ozonest®) treatment, in patients with blepharitis or blepharoconjunctivitis, in improving the signs and symptoms of the pathology.
Methods
Exploratory, open-label, prospective, single-arm, pre-post comparative pilot study in usual clinical practice, in 20 patients with blepharitis/blepharoconjunctivitis, receiving treatment with liposomal ozonated oil, one drop in each eye, 4 times a day, for 28 days. Main purpose was to assess whether there was a clinically improvement in the blepharitis specific BLISS questionnaire score. Changes in the 12-item OSDI, in eyelid signs of blepharitis assessed by the physicians were also evaluated among other tests, and there was also a subjective evaluation of the treatment by patients.
Results
The BLISS score significantly improved from 16.4 before treatment to 11.8 after treatment (p < 0.05). The OSDI score was also significantly improved from 27.5 before treatment to 20.5 after treatment (p < 0.05). All tests conducted before and after treatment showed significant improvement (p < 0.05), except for NIBUT. The treatment received a score of 7 out of 10 by the patients. There were no adverse events in any patient.
Conclusion
Liposomal ozonated oil treatment showed good efficacy in improving the signs and symptoms of blepharitis/blepharoconjunctivitis, satisfaction of patients, and good safety and tolerability.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Infective Agents, Local - administration & dosage</subject><subject>Anti-Infective Agents, Local - pharmacology</subject><subject>Blepharitis - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Liposomes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oils - administration & dosage</subject><subject>Oils - pharmacology</subject><subject>Ozone - administration & dosage</subject><subject>Ozone - pharmacology</subject><subject>Pilot Projects</subject><subject>Prospective Studies</subject><subject>Young Adult</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9LwzAUxYMobk4_gC-SL9CZpFnSPMrwHxR80eeSJjdbRtuUphXmpzdz6ovg0z1czvnBOQhdU7KkVMpbShkRklGWJyEpFSdoTiXjmSBUnCad3tnBMEMXMe4IYURxdo5muSw4F4TM0bb0fYih1Q0OH6HTI1gcfIPBOTCjf4cOYsS-w-MWcPSbLmLdWRz3bT-GNuLgcN1Av9WDH_2XcYpTgpnGd94k0Q86cQxcojOnmwhX33eB3h7uX9dPWfny-Ly-KzPDFBszZ0WumU5lmDDE5aQAbpQqJFcGwMqV5E6AVI6uhFW1KxTYmuaaS-KI0HW-QPTINUOIcQBX9YNv9bCvKKkOq1V_VkuZm2Omn-oW7G_iZ6ZkWB4NUW-g2oVp6FKHf4ifVHd2XA</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Benítez-Del-Castillo, Jose Manuel</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-2010-1701</orcidid></search><sort><creationdate>202405</creationdate><title>Liposomal ozonated oil effectiveness in the signs and symptoms of blepharitis in usual clinical practice</title><author>Benítez-Del-Castillo, Jose Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-fd63a2a71126c0f308e4c998749ceed7574f6e79f156d9bf89edb13a470f06ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Infective Agents, Local - administration & dosage</topic><topic>Anti-Infective Agents, Local - pharmacology</topic><topic>Blepharitis - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Liposomes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oils - administration & dosage</topic><topic>Oils - pharmacology</topic><topic>Ozone - administration & dosage</topic><topic>Ozone - pharmacology</topic><topic>Pilot Projects</topic><topic>Prospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benítez-Del-Castillo, Jose Manuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benítez-Del-Castillo, Jose Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liposomal ozonated oil effectiveness in the signs and symptoms of blepharitis in usual clinical practice</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>European Journal of Ophthalmology</addtitle><date>2024-05</date><risdate>2024</risdate><volume>34</volume><issue>3</issue><spage>678</spage><epage>682</epage><pages>678-682</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>Purpose
To analyze the efficacy of liposomal ozonated oil (Ozonest®) treatment, in patients with blepharitis or blepharoconjunctivitis, in improving the signs and symptoms of the pathology.
Methods
Exploratory, open-label, prospective, single-arm, pre-post comparative pilot study in usual clinical practice, in 20 patients with blepharitis/blepharoconjunctivitis, receiving treatment with liposomal ozonated oil, one drop in each eye, 4 times a day, for 28 days. Main purpose was to assess whether there was a clinically improvement in the blepharitis specific BLISS questionnaire score. Changes in the 12-item OSDI, in eyelid signs of blepharitis assessed by the physicians were also evaluated among other tests, and there was also a subjective evaluation of the treatment by patients.
Results
The BLISS score significantly improved from 16.4 before treatment to 11.8 after treatment (p < 0.05). The OSDI score was also significantly improved from 27.5 before treatment to 20.5 after treatment (p < 0.05). All tests conducted before and after treatment showed significant improvement (p < 0.05), except for NIBUT. The treatment received a score of 7 out of 10 by the patients. There were no adverse events in any patient.
Conclusion
Liposomal ozonated oil treatment showed good efficacy in improving the signs and symptoms of blepharitis/blepharoconjunctivitis, satisfaction of patients, and good safety and tolerability.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>37844600</pmid><doi>10.1177/11206721231207116</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-2010-1701</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1120-6721 |
| ispartof | European journal of ophthalmology, 2024-05, Vol.34 (3), p.678-682 |
| issn | 1120-6721 1724-6016 |
| language | eng |
| recordid | cdi_crossref_primary_10_1177_11206721231207116 |
| source | MEDLINE; SAGE Complete |
| subjects | Adult Aged Aged, 80 and over Anti-Infective Agents, Local - administration & dosage Anti-Infective Agents, Local - pharmacology Blepharitis - therapy Female Humans Liposomes Male Middle Aged Oils - administration & dosage Oils - pharmacology Ozone - administration & dosage Ozone - pharmacology Pilot Projects Prospective Studies Young Adult |
| title | Liposomal ozonated oil effectiveness in the signs and symptoms of blepharitis in usual clinical practice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T00%3A54%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-sage_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Liposomal%20ozonated%20oil%20effectiveness%20in%20the%20signs%20and%20symptoms%20of%20blepharitis%20in%20usual%20clinical%20practice&rft.jtitle=European%20journal%20of%20ophthalmology&rft.au=Ben%C3%ADtez-Del-Castillo,%20Jose%20Manuel&rft.date=2024-05&rft.volume=34&rft.issue=3&rft.spage=678&rft.epage=682&rft.pages=678-682&rft.issn=1120-6721&rft.eissn=1724-6016&rft_id=info:doi/10.1177/11206721231207116&rft_dat=%3Csage_cross%3E10.1177_11206721231207116%3C/sage_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/37844600&rft_sage_id=10.1177_11206721231207116&rfr_iscdi=true |