Birth prevalence and characteristics of congenital corneal opacities
Purpose/Aim To report the birth prevalence and natural history of congenital corneal opacities among a population-based cohort of children. Materials and methods The medical records of patients
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| Veröffentlicht in: | European journal of ophthalmology 2024-05, Vol.34 (3), p.734-738 |
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| container_title | European journal of ophthalmology |
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| creator | Borik, Kaitlynn Mohney, Brian G. Hodge, David Reynolds, Margaret M. |
| description | Purpose/Aim
To report the birth prevalence and natural history of congenital corneal opacities among a population-based cohort of children.
Materials and methods
The medical records of patients |
| doi_str_mv | 10.1177/11206721231202900 |
| format | Article |
| fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1177_11206721231202900</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_11206721231202900</sage_id><sourcerecordid>10.1177_11206721231202900</sourcerecordid><originalsourceid>FETCH-LOGICAL-c340t-bb6b79d9cf65058d80d4e81b98112e440ef856ce166cddcb03f59ef545c50de63</originalsourceid><addsrcrecordid>eNp9UMtOwzAQtBCIlsIHcEH5gcDa8SM-QnlKlbjAOXLsdeuqTSI7ReLvcVXggsRpRquZ0c4QcknhmlKlbihlIBWjrMqEaYAjMqWK8VIClceZ53O5F0zIWUprAAaas1MyqZTildBySu7vQhxXxRDxw2yws1iYzhV2ZaKxI8aQxmBT0fvC9t0SuzCaTaaxw4z9YGwYA6ZzcuLNJuHFN87I--PD2_y5XLw-vcxvF6WtOIxl28pWaaetlwJE7WpwHGva6jo_ipwD-lpIi1RK65xtofJCoxdcWAEOZTUj9JBrY59SRN8MMWxN_GwoNPtFmj-LZM_VwTPs2i26X8fPBFlwfRAks8Rm3e9ilzv8k_gFTYRo_g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Birth prevalence and characteristics of congenital corneal opacities</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><creator>Borik, Kaitlynn ; Mohney, Brian G. ; Hodge, David ; Reynolds, Margaret M.</creator><creatorcontrib>Borik, Kaitlynn ; Mohney, Brian G. ; Hodge, David ; Reynolds, Margaret M.</creatorcontrib><description>Purpose/Aim
To report the birth prevalence and natural history of congenital corneal opacities among a population-based cohort of children.
Materials and methods
The medical records of patients <5 years diagnosed with a congenital onset corneal opacity while residing in Olmsted County, Minnesota, from January 1, 1977, through December 31, 2016, were retrospectively reviewed.
Results
Fourteen patients were diagnosed with a congenital corneal opacity during the 40-year study period for a birth prevalence of 1 in 5188 live births. The mean age at diagnosis was 7.5 months (range 0–48 months) and 9 (64.3%) were males. Four patients had congenital glaucoma, 4 had limbal dermoids, 2 had sclerocornea, and 1 patient each had Descemet's tear from birth trauma, herpes simplex virus type 1 keratitis, corneal leukoma, and an undiagnosed scar. Six (42.8%) patients required treatment for their underlying corneal opacity including the four patients with congenital glaucoma. The other 8 (57.1%) patients had a clear central axis. Four (28.6%) of 14 patients required amblyopia therapy, and 4 (28.6%) developed strabismus. Four (28.6%) patients had associated systemic conditions. During a mean follow up of 5.4 years (range 1.3–27.0 years), the median best corrected visual acuity (BCVA) was logmar 0.16 (20/25) (range 20/20-hand motion) with one patient with unilateral BCVA less than 20/60 and one patient with bilateral BCVA less than 20/60.
Conclusions
In this 40-year cohort, congenital corneal opacities were relatively rare and the result of a variety of disorders. Although amblyopia and strabismus occurred commonly, most patients had good visual outcomes.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.1177/11206721231202900</identifier><identifier>PMID: 37743596</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Child, Preschool ; Corneal Opacity - congenital ; Corneal Opacity - diagnosis ; Corneal Opacity - epidemiology ; Female ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Male ; Minnesota - epidemiology ; Prevalence ; Retrospective Studies ; Visual Acuity - physiology</subject><ispartof>European journal of ophthalmology, 2024-05, Vol.34 (3), p.734-738</ispartof><rights>The Author(s) 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-bb6b79d9cf65058d80d4e81b98112e440ef856ce166cddcb03f59ef545c50de63</citedby><cites>FETCH-LOGICAL-c340t-bb6b79d9cf65058d80d4e81b98112e440ef856ce166cddcb03f59ef545c50de63</cites><orcidid>0000-0002-2588-5517 ; 0000-0001-7678-8090</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/11206721231202900$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/11206721231202900$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21818,27923,27924,43620,43621</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37743596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borik, Kaitlynn</creatorcontrib><creatorcontrib>Mohney, Brian G.</creatorcontrib><creatorcontrib>Hodge, David</creatorcontrib><creatorcontrib>Reynolds, Margaret M.</creatorcontrib><title>Birth prevalence and characteristics of congenital corneal opacities</title><title>European journal of ophthalmology</title><addtitle>European Journal of Ophthalmology</addtitle><description>Purpose/Aim
To report the birth prevalence and natural history of congenital corneal opacities among a population-based cohort of children.
Materials and methods
The medical records of patients <5 years diagnosed with a congenital onset corneal opacity while residing in Olmsted County, Minnesota, from January 1, 1977, through December 31, 2016, were retrospectively reviewed.
Results
Fourteen patients were diagnosed with a congenital corneal opacity during the 40-year study period for a birth prevalence of 1 in 5188 live births. The mean age at diagnosis was 7.5 months (range 0–48 months) and 9 (64.3%) were males. Four patients had congenital glaucoma, 4 had limbal dermoids, 2 had sclerocornea, and 1 patient each had Descemet's tear from birth trauma, herpes simplex virus type 1 keratitis, corneal leukoma, and an undiagnosed scar. Six (42.8%) patients required treatment for their underlying corneal opacity including the four patients with congenital glaucoma. The other 8 (57.1%) patients had a clear central axis. Four (28.6%) of 14 patients required amblyopia therapy, and 4 (28.6%) developed strabismus. Four (28.6%) patients had associated systemic conditions. During a mean follow up of 5.4 years (range 1.3–27.0 years), the median best corrected visual acuity (BCVA) was logmar 0.16 (20/25) (range 20/20-hand motion) with one patient with unilateral BCVA less than 20/60 and one patient with bilateral BCVA less than 20/60.
Conclusions
In this 40-year cohort, congenital corneal opacities were relatively rare and the result of a variety of disorders. Although amblyopia and strabismus occurred commonly, most patients had good visual outcomes.</description><subject>Child, Preschool</subject><subject>Corneal Opacity - congenital</subject><subject>Corneal Opacity - diagnosis</subject><subject>Corneal Opacity - epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Minnesota - epidemiology</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Visual Acuity - physiology</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UMtOwzAQtBCIlsIHcEH5gcDa8SM-QnlKlbjAOXLsdeuqTSI7ReLvcVXggsRpRquZ0c4QcknhmlKlbihlIBWjrMqEaYAjMqWK8VIClceZ53O5F0zIWUprAAaas1MyqZTildBySu7vQhxXxRDxw2yws1iYzhV2ZaKxI8aQxmBT0fvC9t0SuzCaTaaxw4z9YGwYA6ZzcuLNJuHFN87I--PD2_y5XLw-vcxvF6WtOIxl28pWaaetlwJE7WpwHGva6jo_ipwD-lpIi1RK65xtofJCoxdcWAEOZTUj9JBrY59SRN8MMWxN_GwoNPtFmj-LZM_VwTPs2i26X8fPBFlwfRAks8Rm3e9ilzv8k_gFTYRo_g</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Borik, Kaitlynn</creator><creator>Mohney, Brian G.</creator><creator>Hodge, David</creator><creator>Reynolds, Margaret M.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-2588-5517</orcidid><orcidid>https://orcid.org/0000-0001-7678-8090</orcidid></search><sort><creationdate>202405</creationdate><title>Birth prevalence and characteristics of congenital corneal opacities</title><author>Borik, Kaitlynn ; Mohney, Brian G. ; Hodge, David ; Reynolds, Margaret M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-bb6b79d9cf65058d80d4e81b98112e440ef856ce166cddcb03f59ef545c50de63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Child, Preschool</topic><topic>Corneal Opacity - congenital</topic><topic>Corneal Opacity - diagnosis</topic><topic>Corneal Opacity - epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Minnesota - epidemiology</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Visual Acuity - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borik, Kaitlynn</creatorcontrib><creatorcontrib>Mohney, Brian G.</creatorcontrib><creatorcontrib>Hodge, David</creatorcontrib><creatorcontrib>Reynolds, Margaret M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borik, Kaitlynn</au><au>Mohney, Brian G.</au><au>Hodge, David</au><au>Reynolds, Margaret M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Birth prevalence and characteristics of congenital corneal opacities</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>European Journal of Ophthalmology</addtitle><date>2024-05</date><risdate>2024</risdate><volume>34</volume><issue>3</issue><spage>734</spage><epage>738</epage><pages>734-738</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>Purpose/Aim
To report the birth prevalence and natural history of congenital corneal opacities among a population-based cohort of children.
Materials and methods
The medical records of patients <5 years diagnosed with a congenital onset corneal opacity while residing in Olmsted County, Minnesota, from January 1, 1977, through December 31, 2016, were retrospectively reviewed.
Results
Fourteen patients were diagnosed with a congenital corneal opacity during the 40-year study period for a birth prevalence of 1 in 5188 live births. The mean age at diagnosis was 7.5 months (range 0–48 months) and 9 (64.3%) were males. Four patients had congenital glaucoma, 4 had limbal dermoids, 2 had sclerocornea, and 1 patient each had Descemet's tear from birth trauma, herpes simplex virus type 1 keratitis, corneal leukoma, and an undiagnosed scar. Six (42.8%) patients required treatment for their underlying corneal opacity including the four patients with congenital glaucoma. The other 8 (57.1%) patients had a clear central axis. Four (28.6%) of 14 patients required amblyopia therapy, and 4 (28.6%) developed strabismus. Four (28.6%) patients had associated systemic conditions. During a mean follow up of 5.4 years (range 1.3–27.0 years), the median best corrected visual acuity (BCVA) was logmar 0.16 (20/25) (range 20/20-hand motion) with one patient with unilateral BCVA less than 20/60 and one patient with bilateral BCVA less than 20/60.
Conclusions
In this 40-year cohort, congenital corneal opacities were relatively rare and the result of a variety of disorders. Although amblyopia and strabismus occurred commonly, most patients had good visual outcomes.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>37743596</pmid><doi>10.1177/11206721231202900</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-2588-5517</orcidid><orcidid>https://orcid.org/0000-0001-7678-8090</orcidid></addata></record> |
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| ispartof | European journal of ophthalmology, 2024-05, Vol.34 (3), p.734-738 |
| issn | 1120-6721 1724-6016 |
| language | eng |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Child, Preschool Corneal Opacity - congenital Corneal Opacity - diagnosis Corneal Opacity - epidemiology Female Follow-Up Studies Humans Infant Infant, Newborn Male Minnesota - epidemiology Prevalence Retrospective Studies Visual Acuity - physiology |
| title | Birth prevalence and characteristics of congenital corneal opacities |
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