Is there any correlation between alpha-synuclein levels in tears and retinal layer thickness in Parkinson's disease?
Purpose To determine the total alpha-synuclein (αSyn) reflex tears and its association with retinal layers thickness in Parkinson's disease (PD). Methods Fifty-two eyes of 26 PD subjects and 52 eyes of age-and sex-matched healthy controls were included. Total αSyn in reflex tears was quantified...
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| Veröffentlicht in: | European journal of ophthalmology 2024-01, Vol.34 (1), p.252-259 |
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| creator | Camacho-Ordonez, Azyadeh Cervantes-Arriaga, Amin Rodríguez-Violante, Mayela Hernandez-Medrano, Ana Jimena Somilleda-Ventura, Selma Alin Pérez-Cano, Hector J. Nava-Castañeda, Ángel Guerrero-Berger, Oscar |
| description | Purpose
To determine the total alpha-synuclein (αSyn) reflex tears and its association with retinal layers thickness in Parkinson's disease (PD).
Methods
Fifty-two eyes of 26 PD subjects and 52 eyes of age-and sex-matched healthy controls were included. Total αSyn in reflex tears was quantified using a human total αSyn enzyme-linked immunosorbent assay (ELISA) kit. The retinal thickness was evaluated with spectral-domain optical coherence tomography. The Movement Disorder Society-Unified Parkinsońs Disease Rating Scale (MDS-UPDRS), Non-Motor Symptoms Scale (NMSS), and Montreal Cognitive Assessment (MoCA) were used to assess motor, non-motor, and cognition.
Results
In PD, total αSyn levels were increased compared to control subjects [1.76pg/mL (IQR 1.74–1.80) vs 1.73pg/mL (IQR 1.70–1.77), p |
| doi_str_mv | 10.1177/11206721231173725 |
| format | Article |
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To determine the total alpha-synuclein (αSyn) reflex tears and its association with retinal layers thickness in Parkinson's disease (PD).
Methods
Fifty-two eyes of 26 PD subjects and 52 eyes of age-and sex-matched healthy controls were included. Total αSyn in reflex tears was quantified using a human total αSyn enzyme-linked immunosorbent assay (ELISA) kit. The retinal thickness was evaluated with spectral-domain optical coherence tomography. The Movement Disorder Society-Unified Parkinsońs Disease Rating Scale (MDS-UPDRS), Non-Motor Symptoms Scale (NMSS), and Montreal Cognitive Assessment (MoCA) were used to assess motor, non-motor, and cognition.
Results
In PD, total αSyn levels were increased compared to control subjects [1.76pg/mL (IQR 1.74–1.80) vs 1.73pg/mL (IQR 1.70–1.77), p < 0.004]. The nerve fiber layer, ganglion cell layer, internal plexiform layer, inner nuclear layer, and outer nuclear layer were thinner in PD in comparison with controls (p < 0.05). The outer plexiform layer and retinal pigment epithelium were thicker in PD (p < 0.05). The total αSyn levels positively correlated with the central volume of the inner nuclear layer (r = 0.357, p = 0.009).
Conclusion
Total αSyn reflex tear levels were increased in subjects with PD compared to controls. PD patients showed significant thinning of the inner retinal layers and thickening of outer retinal layers in comparison with controls. Total αSyn levels positively correlate with the central volume of the inner nuclear layer in PD. The combination of these biomarkers might have a possible role as a diagnostic tool in PD subjects.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.1177/11206721231173725</identifier><identifier>PMID: 37151018</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>alpha-Synuclein ; Humans ; Nerve Fibers ; Parkinson Disease - diagnosis ; Retina ; Retinal Pigment Epithelium ; Tomography, Optical Coherence - methods</subject><ispartof>European journal of ophthalmology, 2024-01, Vol.34 (1), p.252-259</ispartof><rights>The Author(s) 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c292t-a241f50d49da5a4e20bc0c43d6d348dceb0ee95f1d9e9bddf296eaa6db93fd2a3</cites><orcidid>0000-0003-3714-4406 ; 0000-0002-6531-9288</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/11206721231173725$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/11206721231173725$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37151018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Camacho-Ordonez, Azyadeh</creatorcontrib><creatorcontrib>Cervantes-Arriaga, Amin</creatorcontrib><creatorcontrib>Rodríguez-Violante, Mayela</creatorcontrib><creatorcontrib>Hernandez-Medrano, Ana Jimena</creatorcontrib><creatorcontrib>Somilleda-Ventura, Selma Alin</creatorcontrib><creatorcontrib>Pérez-Cano, Hector J.</creatorcontrib><creatorcontrib>Nava-Castañeda, Ángel</creatorcontrib><creatorcontrib>Guerrero-Berger, Oscar</creatorcontrib><title>Is there any correlation between alpha-synuclein levels in tears and retinal layer thickness in Parkinson's disease?</title><title>European journal of ophthalmology</title><addtitle>European Journal of Ophthalmology</addtitle><description>Purpose
To determine the total alpha-synuclein (αSyn) reflex tears and its association with retinal layers thickness in Parkinson's disease (PD).
Methods
Fifty-two eyes of 26 PD subjects and 52 eyes of age-and sex-matched healthy controls were included. Total αSyn in reflex tears was quantified using a human total αSyn enzyme-linked immunosorbent assay (ELISA) kit. The retinal thickness was evaluated with spectral-domain optical coherence tomography. The Movement Disorder Society-Unified Parkinsońs Disease Rating Scale (MDS-UPDRS), Non-Motor Symptoms Scale (NMSS), and Montreal Cognitive Assessment (MoCA) were used to assess motor, non-motor, and cognition.
Results
In PD, total αSyn levels were increased compared to control subjects [1.76pg/mL (IQR 1.74–1.80) vs 1.73pg/mL (IQR 1.70–1.77), p < 0.004]. The nerve fiber layer, ganglion cell layer, internal plexiform layer, inner nuclear layer, and outer nuclear layer were thinner in PD in comparison with controls (p < 0.05). The outer plexiform layer and retinal pigment epithelium were thicker in PD (p < 0.05). The total αSyn levels positively correlated with the central volume of the inner nuclear layer (r = 0.357, p = 0.009).
Conclusion
Total αSyn reflex tear levels were increased in subjects with PD compared to controls. PD patients showed significant thinning of the inner retinal layers and thickening of outer retinal layers in comparison with controls. Total αSyn levels positively correlate with the central volume of the inner nuclear layer in PD. The combination of these biomarkers might have a possible role as a diagnostic tool in PD subjects.</description><subject>alpha-Synuclein</subject><subject>Humans</subject><subject>Nerve Fibers</subject><subject>Parkinson Disease - diagnosis</subject><subject>Retina</subject><subject>Retinal Pigment Epithelium</subject><subject>Tomography, Optical Coherence - methods</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LAzEQxYMotlb_AC-Sm6fVJPvVnESKH4WCHvS8zCazdts0WzJbpf-9qVUvgqd5w_zeg3mMnUtxJWVZXkupRFEqqdK4pqXKD9hQlipLCiGLw6jjPdkBA3ZCtBBCCZ2pYzZIS5lLIcdD1k-J93MMyMFvuelCQAd923leY_-B6Dm49RwS2vqNcdh67vAdHfGoeoRA0Wd5wL714LiDLYaY15qlR_qCniEsW0-dvyRuW0IgvDllRw04wrPvOWKv93cvk8dk9vQwndzOEqO06hNQmWxyYTNtIYcMlaiNMFlqC5tmY2uwFog6b6TVqGtrG6ULBChsrdPGKkhHTO5zTeiIAjbVOrQrCNtKimrXYPWnwei52HvWm3qF9tfxU1kErvYAwRtWi24T4uf0T-InYWN7vg</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Camacho-Ordonez, Azyadeh</creator><creator>Cervantes-Arriaga, Amin</creator><creator>Rodríguez-Violante, Mayela</creator><creator>Hernandez-Medrano, Ana Jimena</creator><creator>Somilleda-Ventura, Selma Alin</creator><creator>Pérez-Cano, Hector J.</creator><creator>Nava-Castañeda, Ángel</creator><creator>Guerrero-Berger, Oscar</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-3714-4406</orcidid><orcidid>https://orcid.org/0000-0002-6531-9288</orcidid></search><sort><creationdate>202401</creationdate><title>Is there any correlation between alpha-synuclein levels in tears and retinal layer thickness in Parkinson's disease?</title><author>Camacho-Ordonez, Azyadeh ; Cervantes-Arriaga, Amin ; Rodríguez-Violante, Mayela ; Hernandez-Medrano, Ana Jimena ; Somilleda-Ventura, Selma Alin ; Pérez-Cano, Hector J. ; Nava-Castañeda, Ángel ; Guerrero-Berger, Oscar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-a241f50d49da5a4e20bc0c43d6d348dceb0ee95f1d9e9bddf296eaa6db93fd2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>alpha-Synuclein</topic><topic>Humans</topic><topic>Nerve Fibers</topic><topic>Parkinson Disease - diagnosis</topic><topic>Retina</topic><topic>Retinal Pigment Epithelium</topic><topic>Tomography, Optical Coherence - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Camacho-Ordonez, Azyadeh</creatorcontrib><creatorcontrib>Cervantes-Arriaga, Amin</creatorcontrib><creatorcontrib>Rodríguez-Violante, Mayela</creatorcontrib><creatorcontrib>Hernandez-Medrano, Ana Jimena</creatorcontrib><creatorcontrib>Somilleda-Ventura, Selma Alin</creatorcontrib><creatorcontrib>Pérez-Cano, Hector J.</creatorcontrib><creatorcontrib>Nava-Castañeda, Ángel</creatorcontrib><creatorcontrib>Guerrero-Berger, Oscar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Camacho-Ordonez, Azyadeh</au><au>Cervantes-Arriaga, Amin</au><au>Rodríguez-Violante, Mayela</au><au>Hernandez-Medrano, Ana Jimena</au><au>Somilleda-Ventura, Selma Alin</au><au>Pérez-Cano, Hector J.</au><au>Nava-Castañeda, Ángel</au><au>Guerrero-Berger, Oscar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is there any correlation between alpha-synuclein levels in tears and retinal layer thickness in Parkinson's disease?</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>European Journal of Ophthalmology</addtitle><date>2024-01</date><risdate>2024</risdate><volume>34</volume><issue>1</issue><spage>252</spage><epage>259</epage><pages>252-259</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>Purpose
To determine the total alpha-synuclein (αSyn) reflex tears and its association with retinal layers thickness in Parkinson's disease (PD).
Methods
Fifty-two eyes of 26 PD subjects and 52 eyes of age-and sex-matched healthy controls were included. Total αSyn in reflex tears was quantified using a human total αSyn enzyme-linked immunosorbent assay (ELISA) kit. The retinal thickness was evaluated with spectral-domain optical coherence tomography. The Movement Disorder Society-Unified Parkinsońs Disease Rating Scale (MDS-UPDRS), Non-Motor Symptoms Scale (NMSS), and Montreal Cognitive Assessment (MoCA) were used to assess motor, non-motor, and cognition.
Results
In PD, total αSyn levels were increased compared to control subjects [1.76pg/mL (IQR 1.74–1.80) vs 1.73pg/mL (IQR 1.70–1.77), p < 0.004]. The nerve fiber layer, ganglion cell layer, internal plexiform layer, inner nuclear layer, and outer nuclear layer were thinner in PD in comparison with controls (p < 0.05). The outer plexiform layer and retinal pigment epithelium were thicker in PD (p < 0.05). The total αSyn levels positively correlated with the central volume of the inner nuclear layer (r = 0.357, p = 0.009).
Conclusion
Total αSyn reflex tear levels were increased in subjects with PD compared to controls. PD patients showed significant thinning of the inner retinal layers and thickening of outer retinal layers in comparison with controls. Total αSyn levels positively correlate with the central volume of the inner nuclear layer in PD. The combination of these biomarkers might have a possible role as a diagnostic tool in PD subjects.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>37151018</pmid><doi>10.1177/11206721231173725</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3714-4406</orcidid><orcidid>https://orcid.org/0000-0002-6531-9288</orcidid></addata></record> |
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| ispartof | European journal of ophthalmology, 2024-01, Vol.34 (1), p.252-259 |
| issn | 1120-6721 1724-6016 |
| language | eng |
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| source | MEDLINE; SAGE Complete |
| subjects | alpha-Synuclein Humans Nerve Fibers Parkinson Disease - diagnosis Retina Retinal Pigment Epithelium Tomography, Optical Coherence - methods |
| title | Is there any correlation between alpha-synuclein levels in tears and retinal layer thickness in Parkinson's disease? |
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