Contributory factors for developing foveal neovascularization in proliferative diabetic retinopathy
Purpose Foveal neovascularisation (NV) in proliferative diabetic retinopathy (PDR) is uncommon. The study aim is to analyse a series of cases of foveal NV in PDR and ascertain the factors leading to its development. Methods In this retrospective case-control study, optical coherence tomography (OCT)...
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| Veröffentlicht in: | European journal of ophthalmology 2022-11, Vol.32 (6), p.3615-3621 |
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| container_title | European journal of ophthalmology |
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| creator | Venkatesh, Ramesh Reddy, Nikitha Gurram Jayadev, Chaitra Mutalik, Deepashri Agrawal, Sameeksha Mishra, Pranjal Bhatt, Abhishek Yadav, Naresh Kumar Chhablani, Jay |
| description | Purpose
Foveal neovascularisation (NV) in proliferative diabetic retinopathy (PDR) is uncommon. The study aim is to analyse a series of cases of foveal NV in PDR and ascertain the factors leading to its development.
Methods
In this retrospective case-control study, optical coherence tomography (OCT) and OCT-angiography (OCTA) images of PDR cases with/without foveal NV diagnosed on fluorescein angiography were analysed.
Results
From 124 consecutive PDR eyes, foveal NV was identified in 12 (10%) eyes. Eyes with foveal NV showed thin choroid (p = 0.001), increased FAZ area and reduced vessel density at the macula compared to control group on OCT and OCTA. After regression analysis, an increased FAZ in the superficial capillary plexus slab (p = 0.002) was associated with foveal NV development.
Conclusion
Our case series suggest that foveal NV is an uncommon finding, occurring due to reduced choroidal and inner retinal perfusion at the macula. Further studies are required to assess the treatment outcomes in such eyes. |
| doi_str_mv | 10.1177/11206721221075900 |
| format | Article |
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Foveal neovascularisation (NV) in proliferative diabetic retinopathy (PDR) is uncommon. The study aim is to analyse a series of cases of foveal NV in PDR and ascertain the factors leading to its development.
Methods
In this retrospective case-control study, optical coherence tomography (OCT) and OCT-angiography (OCTA) images of PDR cases with/without foveal NV diagnosed on fluorescein angiography were analysed.
Results
From 124 consecutive PDR eyes, foveal NV was identified in 12 (10%) eyes. Eyes with foveal NV showed thin choroid (p = 0.001), increased FAZ area and reduced vessel density at the macula compared to control group on OCT and OCTA. After regression analysis, an increased FAZ in the superficial capillary plexus slab (p = 0.002) was associated with foveal NV development.
Conclusion
Our case series suggest that foveal NV is an uncommon finding, occurring due to reduced choroidal and inner retinal perfusion at the macula. Further studies are required to assess the treatment outcomes in such eyes.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.1177/11206721221075900</identifier><identifier>PMID: 35060418</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><ispartof>European journal of ophthalmology, 2022-11, Vol.32 (6), p.3615-3621</ispartof><rights>The Author(s) 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c292t-a34d014de0a8507efe08fdb1364afdbf010c226028a5e5782205cad69de2b2a13</cites><orcidid>0000-0002-0953-6261 ; 0000-0002-4479-9390 ; 0000-0001-8932-5343 ; 0000-0001-8997-0879 ; 0000-0001-8392-7159</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/11206721221075900$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/11206721221075900$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21824,27929,27930,43626,43627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35060418$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Venkatesh, Ramesh</creatorcontrib><creatorcontrib>Reddy, Nikitha Gurram</creatorcontrib><creatorcontrib>Jayadev, Chaitra</creatorcontrib><creatorcontrib>Mutalik, Deepashri</creatorcontrib><creatorcontrib>Agrawal, Sameeksha</creatorcontrib><creatorcontrib>Mishra, Pranjal</creatorcontrib><creatorcontrib>Bhatt, Abhishek</creatorcontrib><creatorcontrib>Yadav, Naresh Kumar</creatorcontrib><creatorcontrib>Chhablani, Jay</creatorcontrib><title>Contributory factors for developing foveal neovascularization in proliferative diabetic retinopathy</title><title>European journal of ophthalmology</title><addtitle>European Journal of Ophthalmology</addtitle><description>Purpose
Foveal neovascularisation (NV) in proliferative diabetic retinopathy (PDR) is uncommon. The study aim is to analyse a series of cases of foveal NV in PDR and ascertain the factors leading to its development.
Methods
In this retrospective case-control study, optical coherence tomography (OCT) and OCT-angiography (OCTA) images of PDR cases with/without foveal NV diagnosed on fluorescein angiography were analysed.
Results
From 124 consecutive PDR eyes, foveal NV was identified in 12 (10%) eyes. Eyes with foveal NV showed thin choroid (p = 0.001), increased FAZ area and reduced vessel density at the macula compared to control group on OCT and OCTA. After regression analysis, an increased FAZ in the superficial capillary plexus slab (p = 0.002) was associated with foveal NV development.
Conclusion
Our case series suggest that foveal NV is an uncommon finding, occurring due to reduced choroidal and inner retinal perfusion at the macula. Further studies are required to assess the treatment outcomes in such eyes.</description><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9UMtOwzAQtBCIQuEDuCD_QMraefaIKl5SJS5wjjb2urhK48hOIpWvx1WBCxKXnX3MjLTD2I2AhRBleSeEhKKUQkoBZb4EOGEXopRZUoAoTmMf78mBMGOXIWwBJCwzec5maQ4FZKK6YGrlusHbZhyc33ODKmLgxnmuaaLW9bbbxHEibHlHbsKgxha9_cTBuo7bjvfetdaQj4uJuLbY0GAV97F2rsfhY3_Fzgy2ga6_cc7eHx_eVs_J-vXpZXW_TpRcyiHBNNMgMk2AVQ4lGYLK6EakRYYRDQhQUhYgK8wpLyspIVeoi6Um2UgU6ZyJo6_yLgRPpu693aHf1wLqQ2D1n8Ci5vao6cdmR_pX8ZNQJCyOhIAbqrdu9F384R_HLwxEdcQ</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Venkatesh, Ramesh</creator><creator>Reddy, Nikitha Gurram</creator><creator>Jayadev, Chaitra</creator><creator>Mutalik, Deepashri</creator><creator>Agrawal, Sameeksha</creator><creator>Mishra, Pranjal</creator><creator>Bhatt, Abhishek</creator><creator>Yadav, Naresh Kumar</creator><creator>Chhablani, Jay</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-0953-6261</orcidid><orcidid>https://orcid.org/0000-0002-4479-9390</orcidid><orcidid>https://orcid.org/0000-0001-8932-5343</orcidid><orcidid>https://orcid.org/0000-0001-8997-0879</orcidid><orcidid>https://orcid.org/0000-0001-8392-7159</orcidid></search><sort><creationdate>20221101</creationdate><title>Contributory factors for developing foveal neovascularization in proliferative diabetic retinopathy</title><author>Venkatesh, Ramesh ; Reddy, Nikitha Gurram ; Jayadev, Chaitra ; Mutalik, Deepashri ; Agrawal, Sameeksha ; Mishra, Pranjal ; Bhatt, Abhishek ; Yadav, Naresh Kumar ; Chhablani, Jay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-a34d014de0a8507efe08fdb1364afdbf010c226028a5e5782205cad69de2b2a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Venkatesh, Ramesh</creatorcontrib><creatorcontrib>Reddy, Nikitha Gurram</creatorcontrib><creatorcontrib>Jayadev, Chaitra</creatorcontrib><creatorcontrib>Mutalik, Deepashri</creatorcontrib><creatorcontrib>Agrawal, Sameeksha</creatorcontrib><creatorcontrib>Mishra, Pranjal</creatorcontrib><creatorcontrib>Bhatt, Abhishek</creatorcontrib><creatorcontrib>Yadav, Naresh Kumar</creatorcontrib><creatorcontrib>Chhablani, Jay</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Venkatesh, Ramesh</au><au>Reddy, Nikitha Gurram</au><au>Jayadev, Chaitra</au><au>Mutalik, Deepashri</au><au>Agrawal, Sameeksha</au><au>Mishra, Pranjal</au><au>Bhatt, Abhishek</au><au>Yadav, Naresh Kumar</au><au>Chhablani, Jay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contributory factors for developing foveal neovascularization in proliferative diabetic retinopathy</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>European Journal of Ophthalmology</addtitle><date>2022-11-01</date><risdate>2022</risdate><volume>32</volume><issue>6</issue><spage>3615</spage><epage>3621</epage><pages>3615-3621</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>Purpose
Foveal neovascularisation (NV) in proliferative diabetic retinopathy (PDR) is uncommon. The study aim is to analyse a series of cases of foveal NV in PDR and ascertain the factors leading to its development.
Methods
In this retrospective case-control study, optical coherence tomography (OCT) and OCT-angiography (OCTA) images of PDR cases with/without foveal NV diagnosed on fluorescein angiography were analysed.
Results
From 124 consecutive PDR eyes, foveal NV was identified in 12 (10%) eyes. Eyes with foveal NV showed thin choroid (p = 0.001), increased FAZ area and reduced vessel density at the macula compared to control group on OCT and OCTA. After regression analysis, an increased FAZ in the superficial capillary plexus slab (p = 0.002) was associated with foveal NV development.
Conclusion
Our case series suggest that foveal NV is an uncommon finding, occurring due to reduced choroidal and inner retinal perfusion at the macula. Further studies are required to assess the treatment outcomes in such eyes.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>35060418</pmid><doi>10.1177/11206721221075900</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0953-6261</orcidid><orcidid>https://orcid.org/0000-0002-4479-9390</orcidid><orcidid>https://orcid.org/0000-0001-8932-5343</orcidid><orcidid>https://orcid.org/0000-0001-8997-0879</orcidid><orcidid>https://orcid.org/0000-0001-8392-7159</orcidid></addata></record> |
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| title | Contributory factors for developing foveal neovascularization in proliferative diabetic retinopathy |
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