Granulomatous uveitis and choroidal detachment in a patient after topical treatment with Bimatoprost: A case report
Background: Bimatoprost 0.03% is an intraocular pressure (IOP) lowering prostaglandin analog with different adverse side effects such as potential ocular inflammatory effect and ocular hyperemia. Case presentation: We report a case of 80-year-old woman diagnosed with bilateral glaucomatous uveitis,...
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| Veröffentlicht in: | European journal of ophthalmology 2022-05, Vol.32 (3), p.NP19-NP22 |
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| container_title | European journal of ophthalmology |
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| creator | Massimo, Lorusso Micelli Ferrari, Luisa Nikolopoulou Gisotti, Eleni Zito, Roberta MicelliFerrari, Tommaso Anna, Ferretta Bordinone, Marco Antonio |
| description | Background:
Bimatoprost 0.03% is an intraocular pressure (IOP) lowering prostaglandin analog with different adverse side effects such as potential ocular inflammatory effect and ocular hyperemia.
Case presentation:
We report a case of 80-year-old woman diagnosed with bilateral glaucomatous uveitis, and choroidal detachment in the left eye after topical bimatoprost administration. During the patient’s hospitalization, Bimatoprost treatment was discontinued and local steroid therapy was administrated. After 1 week we reported a marked improvement of visual acuity, IOP measurement was 12 mmHg in both eyes. Anterior segment examination showed complete resolution of conjunctival and pericheratic hyperemia with significant reduction of endothelial precipitates in both eyes.
Conclusions:
In our case, the anterior granulomatous uveitis occurred in both pseudophakic eyes and the choroidal detachment (CD) in the eye that previously had trabeculectomy. Probably the scar tissue of the trabeculectomy allowed a better penetration of the Bimatoprost or a greater sensitivity due to an altered trabecular tissue. This work confirms that the onset physiopathology mechanism of granulomatous uveitis and CD following instillation of Bimatoprost remains uncertain. |
| doi_str_mv | 10.1177/1120672121990573 |
| format | Article |
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Bimatoprost 0.03% is an intraocular pressure (IOP) lowering prostaglandin analog with different adverse side effects such as potential ocular inflammatory effect and ocular hyperemia.
Case presentation:
We report a case of 80-year-old woman diagnosed with bilateral glaucomatous uveitis, and choroidal detachment in the left eye after topical bimatoprost administration. During the patient’s hospitalization, Bimatoprost treatment was discontinued and local steroid therapy was administrated. After 1 week we reported a marked improvement of visual acuity, IOP measurement was 12 mmHg in both eyes. Anterior segment examination showed complete resolution of conjunctival and pericheratic hyperemia with significant reduction of endothelial precipitates in both eyes.
Conclusions:
In our case, the anterior granulomatous uveitis occurred in both pseudophakic eyes and the choroidal detachment (CD) in the eye that previously had trabeculectomy. Probably the scar tissue of the trabeculectomy allowed a better penetration of the Bimatoprost or a greater sensitivity due to an altered trabecular tissue. This work confirms that the onset physiopathology mechanism of granulomatous uveitis and CD following instillation of Bimatoprost remains uncertain.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.1177/1120672121990573</identifier><identifier>PMID: 33508974</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged, 80 and over ; Amides - adverse effects ; Antihypertensive Agents - therapeutic use ; Bimatoprost - adverse effects ; Choroidal Effusions ; Cloprostenol - therapeutic use ; Female ; Glaucoma - chemically induced ; Glaucoma - drug therapy ; Humans ; Hyperemia - chemically induced ; Intraocular Pressure ; Uveitis - chemically induced ; Uveitis - diagnosis ; Uveitis - drug therapy ; Uveitis, Anterior - drug therapy</subject><ispartof>European journal of ophthalmology, 2022-05, Vol.32 (3), p.NP19-NP22</ispartof><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-34f6e3c18ed83c6b01860a49921c1c12756ce91902fe30c3474fcf346593c1263</citedby><cites>FETCH-LOGICAL-c337t-34f6e3c18ed83c6b01860a49921c1c12756ce91902fe30c3474fcf346593c1263</cites><orcidid>0000-0003-2279-9557 ; 0000-0002-3624-1776</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1120672121990573$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1120672121990573$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33508974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Massimo, Lorusso</creatorcontrib><creatorcontrib>Micelli Ferrari, Luisa</creatorcontrib><creatorcontrib>Nikolopoulou Gisotti, Eleni</creatorcontrib><creatorcontrib>Zito, Roberta</creatorcontrib><creatorcontrib>MicelliFerrari, Tommaso</creatorcontrib><creatorcontrib>Anna, Ferretta</creatorcontrib><creatorcontrib>Bordinone, Marco Antonio</creatorcontrib><title>Granulomatous uveitis and choroidal detachment in a patient after topical treatment with Bimatoprost: A case report</title><title>European journal of ophthalmology</title><addtitle>Eur J Ophthalmol</addtitle><description>Background:
Bimatoprost 0.03% is an intraocular pressure (IOP) lowering prostaglandin analog with different adverse side effects such as potential ocular inflammatory effect and ocular hyperemia.
Case presentation:
We report a case of 80-year-old woman diagnosed with bilateral glaucomatous uveitis, and choroidal detachment in the left eye after topical bimatoprost administration. During the patient’s hospitalization, Bimatoprost treatment was discontinued and local steroid therapy was administrated. After 1 week we reported a marked improvement of visual acuity, IOP measurement was 12 mmHg in both eyes. Anterior segment examination showed complete resolution of conjunctival and pericheratic hyperemia with significant reduction of endothelial precipitates in both eyes.
Conclusions:
In our case, the anterior granulomatous uveitis occurred in both pseudophakic eyes and the choroidal detachment (CD) in the eye that previously had trabeculectomy. Probably the scar tissue of the trabeculectomy allowed a better penetration of the Bimatoprost or a greater sensitivity due to an altered trabecular tissue. This work confirms that the onset physiopathology mechanism of granulomatous uveitis and CD following instillation of Bimatoprost remains uncertain.</description><subject>Aged, 80 and over</subject><subject>Amides - adverse effects</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Bimatoprost - adverse effects</subject><subject>Choroidal Effusions</subject><subject>Cloprostenol - therapeutic use</subject><subject>Female</subject><subject>Glaucoma - chemically induced</subject><subject>Glaucoma - drug therapy</subject><subject>Humans</subject><subject>Hyperemia - chemically induced</subject><subject>Intraocular Pressure</subject><subject>Uveitis - chemically induced</subject><subject>Uveitis - diagnosis</subject><subject>Uveitis - drug therapy</subject><subject>Uveitis, Anterior - drug therapy</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UMtOwzAQtBCIQuHOCfkHAn7FjrmVCgpSJS5wjlxnQ121cWQ7IP4ehwIHJLSH3dXOjGYHoQtKrihV6ppSRqRilFGtSan4ATqhiolCEioP85zPxXifoNMYN4QwogU7RhPOS1JpJU5QXATTDVu_M8kPEQ9v4JKL2HQNtmsfvGvMFjeQjF3voEvYddjg3iQ3LqZNEHDyvbMZlQKY9AV6d2mNb92o2Qcf0w2eYWsi4AC9D-kMHbVmG-H8u0_Ry_3d8_yhWD4tHuezZWE5V6ngopXALa2gqbiVK0IrSYzQmlGbi6lSWtBUE9YCJ5YLJVrbciFLnVlM8ikie12bTcQAbd2HbCp81JTUY3713_wy5XJP6YfVDppfwk9gGVDsAdG8Qr3xQ-jyC_8LfgKatHi5</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Massimo, Lorusso</creator><creator>Micelli Ferrari, Luisa</creator><creator>Nikolopoulou Gisotti, Eleni</creator><creator>Zito, Roberta</creator><creator>MicelliFerrari, Tommaso</creator><creator>Anna, Ferretta</creator><creator>Bordinone, Marco Antonio</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-2279-9557</orcidid><orcidid>https://orcid.org/0000-0002-3624-1776</orcidid></search><sort><creationdate>20220501</creationdate><title>Granulomatous uveitis and choroidal detachment in a patient after topical treatment with Bimatoprost: A case report</title><author>Massimo, Lorusso ; Micelli Ferrari, Luisa ; Nikolopoulou Gisotti, Eleni ; Zito, Roberta ; MicelliFerrari, Tommaso ; Anna, Ferretta ; Bordinone, Marco Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-34f6e3c18ed83c6b01860a49921c1c12756ce91902fe30c3474fcf346593c1263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged, 80 and over</topic><topic>Amides - adverse effects</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Bimatoprost - adverse effects</topic><topic>Choroidal Effusions</topic><topic>Cloprostenol - therapeutic use</topic><topic>Female</topic><topic>Glaucoma - chemically induced</topic><topic>Glaucoma - drug therapy</topic><topic>Humans</topic><topic>Hyperemia - chemically induced</topic><topic>Intraocular Pressure</topic><topic>Uveitis - chemically induced</topic><topic>Uveitis - diagnosis</topic><topic>Uveitis - drug therapy</topic><topic>Uveitis, Anterior - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Massimo, Lorusso</creatorcontrib><creatorcontrib>Micelli Ferrari, Luisa</creatorcontrib><creatorcontrib>Nikolopoulou Gisotti, Eleni</creatorcontrib><creatorcontrib>Zito, Roberta</creatorcontrib><creatorcontrib>MicelliFerrari, Tommaso</creatorcontrib><creatorcontrib>Anna, Ferretta</creatorcontrib><creatorcontrib>Bordinone, Marco Antonio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Massimo, Lorusso</au><au>Micelli Ferrari, Luisa</au><au>Nikolopoulou Gisotti, Eleni</au><au>Zito, Roberta</au><au>MicelliFerrari, Tommaso</au><au>Anna, Ferretta</au><au>Bordinone, Marco Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Granulomatous uveitis and choroidal detachment in a patient after topical treatment with Bimatoprost: A case report</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>Eur J Ophthalmol</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>32</volume><issue>3</issue><spage>NP19</spage><epage>NP22</epage><pages>NP19-NP22</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>Background:
Bimatoprost 0.03% is an intraocular pressure (IOP) lowering prostaglandin analog with different adverse side effects such as potential ocular inflammatory effect and ocular hyperemia.
Case presentation:
We report a case of 80-year-old woman diagnosed with bilateral glaucomatous uveitis, and choroidal detachment in the left eye after topical bimatoprost administration. During the patient’s hospitalization, Bimatoprost treatment was discontinued and local steroid therapy was administrated. After 1 week we reported a marked improvement of visual acuity, IOP measurement was 12 mmHg in both eyes. Anterior segment examination showed complete resolution of conjunctival and pericheratic hyperemia with significant reduction of endothelial precipitates in both eyes.
Conclusions:
In our case, the anterior granulomatous uveitis occurred in both pseudophakic eyes and the choroidal detachment (CD) in the eye that previously had trabeculectomy. Probably the scar tissue of the trabeculectomy allowed a better penetration of the Bimatoprost or a greater sensitivity due to an altered trabecular tissue. This work confirms that the onset physiopathology mechanism of granulomatous uveitis and CD following instillation of Bimatoprost remains uncertain.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>33508974</pmid><doi>10.1177/1120672121990573</doi><orcidid>https://orcid.org/0000-0003-2279-9557</orcidid><orcidid>https://orcid.org/0000-0002-3624-1776</orcidid></addata></record> |
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| subjects | Aged, 80 and over Amides - adverse effects Antihypertensive Agents - therapeutic use Bimatoprost - adverse effects Choroidal Effusions Cloprostenol - therapeutic use Female Glaucoma - chemically induced Glaucoma - drug therapy Humans Hyperemia - chemically induced Intraocular Pressure Uveitis - chemically induced Uveitis - diagnosis Uveitis - drug therapy Uveitis, Anterior - drug therapy |
| title | Granulomatous uveitis and choroidal detachment in a patient after topical treatment with Bimatoprost: A case report |
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