OCT-Angiography as a reliable prognostic tool in laser-treated proliferative diabetic retinopathy: The RENOCTA Study
Purpose: To quantitatively assess retinal neovascularizations (RNVs) in proliferative diabetic retinopathy (PDR) before and after photocoagulative laser treatment (PLT) using Optical Coherence Tomography Angiography (OCT-A). Methods: Consecutive patients with PDR were examined with fluorescein angio...
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| Veröffentlicht in: | European journal of ophthalmology 2021-09, Vol.31 (5), p.2511-2519 |
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| creator | Lupidi, Marco Gujar, Ramkailash Cerquaglia, Alessio Chablani, Jay Fruttini, Daniela Muzi, Alessio Corbucci, Roberta Fiore, Tito Coscas, Florence Coscas, Gabriel Parravano, Mariacristina Cagini, Carlo |
| description | Purpose:
To quantitatively assess retinal neovascularizations (RNVs) in proliferative diabetic retinopathy (PDR) before and after photocoagulative laser treatment (PLT) using Optical Coherence Tomography Angiography (OCT-A).
Methods:
Consecutive patients with PDR were examined with fluorescein angiography (FA) and OCT-A before and after PLT. Baseline and after-treatment FA images were quantitatively analyzed to assess both the RNVs area and leakage area. On OCT-A RNVs area, vascular perfusion density (VPD), vessel length density (VLD) and fractal dimension were computed. VPD of the full-retina OCT-A underneath the RNV was determined to evaluate potential laser-induced changes in vascular perfusion.
Results:
Fifteen eyes of 13 patients with PDR were enrolled. The mean area of the RNVs was 0.47 ± 0.50 mm2 in the baseline OCT-A and 0.32 ± 0.40 mm2 in the post-treatment assessment (p = 0.0002). The mean RNV VPD of RNV was 2% ± 4% in pre-treatment and 1% ± 1% for the post-treatment (p = 0.0001). The mean VLD of RNV was 7.26 ± 1.53 at baseline and 6.64 ± 1.65 in the post treatment (p = 0.0002). A significant difference in terms of mean RNVs area and VPD reduction between eyes that needed additional treatment and those that did not (~40% vs ~20%; p |
| doi_str_mv | 10.1177/1120672120963451 |
| format | Article |
| fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1177_1120672120963451</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1120672120963451</sage_id><sourcerecordid>10.1177_1120672120963451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-6c4a4f60cc710523219d45a767fab6359123ebfad1827f05cb902c99404f24183</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMotlbvniR_IJqvTbreSqkfIBa0npdsNtlu2W6WJBX235ul6kHwMjPwPu8M8wJwTfAtIVLeEUKxkDTVXDCekRMwJZJyJDARp2lOAhr1CbgIYYdx4jg9BxPGCMt4zqcgrpcbtOjqxtVe9dsBqgAV9KZtVNka2HtXdy7ERsPoXAubDrYqGI-iNyqaagTaxhqvYvNpYJVcZoR9qp3rVdwO93CzNfBt9ZouLeB7PFTDJTizqg3m6rvPwMfDarN8Qi_rx-fl4gVpxmREQnPFrcBaS4IzyijJK54pKaRVpWBZTigzpVUVmVNpcabLHFOd5xxzSzmZsxnAx73auxC8sUXvm73yQ0FwMQZY_A0wWW6Olv5Q7k31a_hJLAHoCARVm2LnDr5LL_y_8AvCvHfz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>OCT-Angiography as a reliable prognostic tool in laser-treated proliferative diabetic retinopathy: The RENOCTA Study</title><source>Access via SAGE</source><source>MEDLINE</source><creator>Lupidi, Marco ; Gujar, Ramkailash ; Cerquaglia, Alessio ; Chablani, Jay ; Fruttini, Daniela ; Muzi, Alessio ; Corbucci, Roberta ; Fiore, Tito ; Coscas, Florence ; Coscas, Gabriel ; Parravano, Mariacristina ; Cagini, Carlo</creator><creatorcontrib>Lupidi, Marco ; Gujar, Ramkailash ; Cerquaglia, Alessio ; Chablani, Jay ; Fruttini, Daniela ; Muzi, Alessio ; Corbucci, Roberta ; Fiore, Tito ; Coscas, Florence ; Coscas, Gabriel ; Parravano, Mariacristina ; Cagini, Carlo</creatorcontrib><description>Purpose:
To quantitatively assess retinal neovascularizations (RNVs) in proliferative diabetic retinopathy (PDR) before and after photocoagulative laser treatment (PLT) using Optical Coherence Tomography Angiography (OCT-A).
Methods:
Consecutive patients with PDR were examined with fluorescein angiography (FA) and OCT-A before and after PLT. Baseline and after-treatment FA images were quantitatively analyzed to assess both the RNVs area and leakage area. On OCT-A RNVs area, vascular perfusion density (VPD), vessel length density (VLD) and fractal dimension were computed. VPD of the full-retina OCT-A underneath the RNV was determined to evaluate potential laser-induced changes in vascular perfusion.
Results:
Fifteen eyes of 13 patients with PDR were enrolled. The mean area of the RNVs was 0.47 ± 0.50 mm2 in the baseline OCT-A and 0.32 ± 0.40 mm2 in the post-treatment assessment (p = 0.0002). The mean RNV VPD of RNV was 2% ± 4% in pre-treatment and 1% ± 1% for the post-treatment (p = 0.0001). The mean VLD of RNV was 7.26 ± 1.53 at baseline and 6.64 ± 1.65 in the post treatment (p = 0.0002). A significant difference in terms of mean RNVs area and VPD reduction between eyes that needed additional treatment and those that did not (~40% vs ~20%; p < 0.05), was observed. Mean VPD of full-retinal thickness OCT-angiogram was 55% ± 10% for the pre-treatment and 53% ± 8% for the post treatment scan (p = 0.02).
Conclusion:
The quantitative OCT-A assessment of laser-induced changes of RNVs can be a useful non-invasive approach for determining treatment efficacy. A reduction of RNVs area or VPD ⩾ 40% might reveal those eyes that won’t require additional treatment. Retinal perfusion impairment seemed to progress independently from the treatment.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.1177/1120672120963451</identifier><identifier>PMID: 33135494</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Diabetes Mellitus ; Diabetic Retinopathy - diagnostic imaging ; Diabetic Retinopathy - surgery ; Fluorescein Angiography ; Humans ; Lasers ; Prognosis ; Retinal Vessels - diagnostic imaging ; Tomography, Optical Coherence</subject><ispartof>European journal of ophthalmology, 2021-09, Vol.31 (5), p.2511-2519</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-6c4a4f60cc710523219d45a767fab6359123ebfad1827f05cb902c99404f24183</citedby><cites>FETCH-LOGICAL-c337t-6c4a4f60cc710523219d45a767fab6359123ebfad1827f05cb902c99404f24183</cites><orcidid>0000-0002-6817-2488 ; 0000-0002-2223-7311 ; 0000-0003-2765-0639 ; 0000-0002-9888-5040 ; 0000-0002-3812-9219</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1120672120963451$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1120672120963451$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33135494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lupidi, Marco</creatorcontrib><creatorcontrib>Gujar, Ramkailash</creatorcontrib><creatorcontrib>Cerquaglia, Alessio</creatorcontrib><creatorcontrib>Chablani, Jay</creatorcontrib><creatorcontrib>Fruttini, Daniela</creatorcontrib><creatorcontrib>Muzi, Alessio</creatorcontrib><creatorcontrib>Corbucci, Roberta</creatorcontrib><creatorcontrib>Fiore, Tito</creatorcontrib><creatorcontrib>Coscas, Florence</creatorcontrib><creatorcontrib>Coscas, Gabriel</creatorcontrib><creatorcontrib>Parravano, Mariacristina</creatorcontrib><creatorcontrib>Cagini, Carlo</creatorcontrib><title>OCT-Angiography as a reliable prognostic tool in laser-treated proliferative diabetic retinopathy: The RENOCTA Study</title><title>European journal of ophthalmology</title><addtitle>Eur J Ophthalmol</addtitle><description>Purpose:
To quantitatively assess retinal neovascularizations (RNVs) in proliferative diabetic retinopathy (PDR) before and after photocoagulative laser treatment (PLT) using Optical Coherence Tomography Angiography (OCT-A).
Methods:
Consecutive patients with PDR were examined with fluorescein angiography (FA) and OCT-A before and after PLT. Baseline and after-treatment FA images were quantitatively analyzed to assess both the RNVs area and leakage area. On OCT-A RNVs area, vascular perfusion density (VPD), vessel length density (VLD) and fractal dimension were computed. VPD of the full-retina OCT-A underneath the RNV was determined to evaluate potential laser-induced changes in vascular perfusion.
Results:
Fifteen eyes of 13 patients with PDR were enrolled. The mean area of the RNVs was 0.47 ± 0.50 mm2 in the baseline OCT-A and 0.32 ± 0.40 mm2 in the post-treatment assessment (p = 0.0002). The mean RNV VPD of RNV was 2% ± 4% in pre-treatment and 1% ± 1% for the post-treatment (p = 0.0001). The mean VLD of RNV was 7.26 ± 1.53 at baseline and 6.64 ± 1.65 in the post treatment (p = 0.0002). A significant difference in terms of mean RNVs area and VPD reduction between eyes that needed additional treatment and those that did not (~40% vs ~20%; p < 0.05), was observed. Mean VPD of full-retinal thickness OCT-angiogram was 55% ± 10% for the pre-treatment and 53% ± 8% for the post treatment scan (p = 0.02).
Conclusion:
The quantitative OCT-A assessment of laser-induced changes of RNVs can be a useful non-invasive approach for determining treatment efficacy. A reduction of RNVs area or VPD ⩾ 40% might reveal those eyes that won’t require additional treatment. Retinal perfusion impairment seemed to progress independently from the treatment.</description><subject>Diabetes Mellitus</subject><subject>Diabetic Retinopathy - diagnostic imaging</subject><subject>Diabetic Retinopathy - surgery</subject><subject>Fluorescein Angiography</subject><subject>Humans</subject><subject>Lasers</subject><subject>Prognosis</subject><subject>Retinal Vessels - diagnostic imaging</subject><subject>Tomography, Optical Coherence</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMotlbvniR_IJqvTbreSqkfIBa0npdsNtlu2W6WJBX235ul6kHwMjPwPu8M8wJwTfAtIVLeEUKxkDTVXDCekRMwJZJyJDARp2lOAhr1CbgIYYdx4jg9BxPGCMt4zqcgrpcbtOjqxtVe9dsBqgAV9KZtVNka2HtXdy7ERsPoXAubDrYqGI-iNyqaagTaxhqvYvNpYJVcZoR9qp3rVdwO93CzNfBt9ZouLeB7PFTDJTizqg3m6rvPwMfDarN8Qi_rx-fl4gVpxmREQnPFrcBaS4IzyijJK54pKaRVpWBZTigzpVUVmVNpcabLHFOd5xxzSzmZsxnAx73auxC8sUXvm73yQ0FwMQZY_A0wWW6Olv5Q7k31a_hJLAHoCARVm2LnDr5LL_y_8AvCvHfz</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Lupidi, Marco</creator><creator>Gujar, Ramkailash</creator><creator>Cerquaglia, Alessio</creator><creator>Chablani, Jay</creator><creator>Fruttini, Daniela</creator><creator>Muzi, Alessio</creator><creator>Corbucci, Roberta</creator><creator>Fiore, Tito</creator><creator>Coscas, Florence</creator><creator>Coscas, Gabriel</creator><creator>Parravano, Mariacristina</creator><creator>Cagini, Carlo</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-6817-2488</orcidid><orcidid>https://orcid.org/0000-0002-2223-7311</orcidid><orcidid>https://orcid.org/0000-0003-2765-0639</orcidid><orcidid>https://orcid.org/0000-0002-9888-5040</orcidid><orcidid>https://orcid.org/0000-0002-3812-9219</orcidid></search><sort><creationdate>202109</creationdate><title>OCT-Angiography as a reliable prognostic tool in laser-treated proliferative diabetic retinopathy: The RENOCTA Study</title><author>Lupidi, Marco ; Gujar, Ramkailash ; Cerquaglia, Alessio ; Chablani, Jay ; Fruttini, Daniela ; Muzi, Alessio ; Corbucci, Roberta ; Fiore, Tito ; Coscas, Florence ; Coscas, Gabriel ; Parravano, Mariacristina ; Cagini, Carlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-6c4a4f60cc710523219d45a767fab6359123ebfad1827f05cb902c99404f24183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Diabetes Mellitus</topic><topic>Diabetic Retinopathy - diagnostic imaging</topic><topic>Diabetic Retinopathy - surgery</topic><topic>Fluorescein Angiography</topic><topic>Humans</topic><topic>Lasers</topic><topic>Prognosis</topic><topic>Retinal Vessels - diagnostic imaging</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lupidi, Marco</creatorcontrib><creatorcontrib>Gujar, Ramkailash</creatorcontrib><creatorcontrib>Cerquaglia, Alessio</creatorcontrib><creatorcontrib>Chablani, Jay</creatorcontrib><creatorcontrib>Fruttini, Daniela</creatorcontrib><creatorcontrib>Muzi, Alessio</creatorcontrib><creatorcontrib>Corbucci, Roberta</creatorcontrib><creatorcontrib>Fiore, Tito</creatorcontrib><creatorcontrib>Coscas, Florence</creatorcontrib><creatorcontrib>Coscas, Gabriel</creatorcontrib><creatorcontrib>Parravano, Mariacristina</creatorcontrib><creatorcontrib>Cagini, Carlo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lupidi, Marco</au><au>Gujar, Ramkailash</au><au>Cerquaglia, Alessio</au><au>Chablani, Jay</au><au>Fruttini, Daniela</au><au>Muzi, Alessio</au><au>Corbucci, Roberta</au><au>Fiore, Tito</au><au>Coscas, Florence</au><au>Coscas, Gabriel</au><au>Parravano, Mariacristina</au><au>Cagini, Carlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>OCT-Angiography as a reliable prognostic tool in laser-treated proliferative diabetic retinopathy: The RENOCTA Study</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>Eur J Ophthalmol</addtitle><date>2021-09</date><risdate>2021</risdate><volume>31</volume><issue>5</issue><spage>2511</spage><epage>2519</epage><pages>2511-2519</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>Purpose:
To quantitatively assess retinal neovascularizations (RNVs) in proliferative diabetic retinopathy (PDR) before and after photocoagulative laser treatment (PLT) using Optical Coherence Tomography Angiography (OCT-A).
Methods:
Consecutive patients with PDR were examined with fluorescein angiography (FA) and OCT-A before and after PLT. Baseline and after-treatment FA images were quantitatively analyzed to assess both the RNVs area and leakage area. On OCT-A RNVs area, vascular perfusion density (VPD), vessel length density (VLD) and fractal dimension were computed. VPD of the full-retina OCT-A underneath the RNV was determined to evaluate potential laser-induced changes in vascular perfusion.
Results:
Fifteen eyes of 13 patients with PDR were enrolled. The mean area of the RNVs was 0.47 ± 0.50 mm2 in the baseline OCT-A and 0.32 ± 0.40 mm2 in the post-treatment assessment (p = 0.0002). The mean RNV VPD of RNV was 2% ± 4% in pre-treatment and 1% ± 1% for the post-treatment (p = 0.0001). The mean VLD of RNV was 7.26 ± 1.53 at baseline and 6.64 ± 1.65 in the post treatment (p = 0.0002). A significant difference in terms of mean RNVs area and VPD reduction between eyes that needed additional treatment and those that did not (~40% vs ~20%; p < 0.05), was observed. Mean VPD of full-retinal thickness OCT-angiogram was 55% ± 10% for the pre-treatment and 53% ± 8% for the post treatment scan (p = 0.02).
Conclusion:
The quantitative OCT-A assessment of laser-induced changes of RNVs can be a useful non-invasive approach for determining treatment efficacy. A reduction of RNVs area or VPD ⩾ 40% might reveal those eyes that won’t require additional treatment. Retinal perfusion impairment seemed to progress independently from the treatment.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>33135494</pmid><doi>10.1177/1120672120963451</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6817-2488</orcidid><orcidid>https://orcid.org/0000-0002-2223-7311</orcidid><orcidid>https://orcid.org/0000-0003-2765-0639</orcidid><orcidid>https://orcid.org/0000-0002-9888-5040</orcidid><orcidid>https://orcid.org/0000-0002-3812-9219</orcidid></addata></record> |
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| source | Access via SAGE; MEDLINE |
| subjects | Diabetes Mellitus Diabetic Retinopathy - diagnostic imaging Diabetic Retinopathy - surgery Fluorescein Angiography Humans Lasers Prognosis Retinal Vessels - diagnostic imaging Tomography, Optical Coherence |
| title | OCT-Angiography as a reliable prognostic tool in laser-treated proliferative diabetic retinopathy: The RENOCTA Study |
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