Clinical findings and outcomes of uveitis associated with multiple sclerosis
Purpose: To describe the clinical findings and outcomes in patients who presented with uveitis associated with multiple sclerosis. Methods: Retrospective review of 20 patients (38 eyes). Results: The most frequent ocular finding was multifocal elongated retinal perivenous “sheathing” with focal vasc...
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| Veröffentlicht in: | European journal of ophthalmology 2021-03, Vol.31 (2), p.482-490 |
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| container_title | European journal of ophthalmology |
| container_volume | 31 |
| creator | AlBloushi, Abdulrahman F Dheyab, Abdulsalam M Al-Swaina, Nayef F Al-Obailan, Majed Daif, Abdul-kader Abu El-Asrar, Ahmed M |
| description | Purpose:
To describe the clinical findings and outcomes in patients who presented with uveitis associated with multiple sclerosis.
Methods:
Retrospective review of 20 patients (38 eyes).
Results:
The most frequent ocular finding was multifocal elongated retinal perivenous “sheathing” with focal vascular leakage on fundus fluorescein angiography in 29 eyes followed by vitreous snowballs and debris in 26 eyes, anterior chamber inflammation in 15 eyes, mutton-fat keratic precipitates in 14 eyes, posterior synechiae in 13 eyes, cystoid macular edema in 9 eyes, iris nodules in 4 eyes, and optic neuritis in 3 eyes. Patients with cystoid macular edema were treated successfully with systemic corticosteroids combined with mycophenolate mofetil. Ocular complications were cataract in 6 eyes, glaucoma in 2 eyes and vitreous hemorrhage in 1 eye.
Conclusions:
Multifocal elongated retinal perivenous “sheathing” with focal vascular leakage on fundus fluorescein angiography is the most frequent finding in uveitis associated with multiple sclerosis. |
| doi_str_mv | 10.1177/1120672120904667 |
| format | Article |
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To describe the clinical findings and outcomes in patients who presented with uveitis associated with multiple sclerosis.
Methods:
Retrospective review of 20 patients (38 eyes).
Results:
The most frequent ocular finding was multifocal elongated retinal perivenous “sheathing” with focal vascular leakage on fundus fluorescein angiography in 29 eyes followed by vitreous snowballs and debris in 26 eyes, anterior chamber inflammation in 15 eyes, mutton-fat keratic precipitates in 14 eyes, posterior synechiae in 13 eyes, cystoid macular edema in 9 eyes, iris nodules in 4 eyes, and optic neuritis in 3 eyes. Patients with cystoid macular edema were treated successfully with systemic corticosteroids combined with mycophenolate mofetil. Ocular complications were cataract in 6 eyes, glaucoma in 2 eyes and vitreous hemorrhage in 1 eye.
Conclusions:
Multifocal elongated retinal perivenous “sheathing” with focal vascular leakage on fundus fluorescein angiography is the most frequent finding in uveitis associated with multiple sclerosis.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.1177/1120672120904667</identifier><identifier>PMID: 32019337</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adolescent ; Adult ; Child ; Female ; Fluorescein Angiography ; Glucocorticoids - therapeutic use ; Humans ; Macular Edema - diagnostic imaging ; Magnetic Resonance Imaging ; Male ; Methylprednisolone - therapeutic use ; Middle Aged ; Multiple Sclerosis - complications ; Multiple Sclerosis - diagnostic imaging ; Multiple Sclerosis - drug therapy ; Multiple Sclerosis - physiopathology ; Optic Neuritis - diagnostic imaging ; Retrospective Studies ; Slit Lamp Microscopy ; Tomography, Optical Coherence ; Uveitis - complications ; Uveitis - diagnostic imaging ; Uveitis - drug therapy ; Uveitis - physiopathology ; Visual Acuity - physiology ; Young Adult</subject><ispartof>European journal of ophthalmology, 2021-03, Vol.31 (2), p.482-490</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-de78d160e48a1757176d01d25cd143d5cd6b8688fe66f1b5c248fa021fe1994c3</citedby><cites>FETCH-LOGICAL-c337t-de78d160e48a1757176d01d25cd143d5cd6b8688fe66f1b5c248fa021fe1994c3</cites><orcidid>0000-0003-2226-8617 ; 0000-0003-1104-9208</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1120672120904667$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1120672120904667$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32019337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AlBloushi, Abdulrahman F</creatorcontrib><creatorcontrib>Dheyab, Abdulsalam M</creatorcontrib><creatorcontrib>Al-Swaina, Nayef F</creatorcontrib><creatorcontrib>Al-Obailan, Majed</creatorcontrib><creatorcontrib>Daif, Abdul-kader</creatorcontrib><creatorcontrib>Abu El-Asrar, Ahmed M</creatorcontrib><title>Clinical findings and outcomes of uveitis associated with multiple sclerosis</title><title>European journal of ophthalmology</title><addtitle>Eur J Ophthalmol</addtitle><description>Purpose:
To describe the clinical findings and outcomes in patients who presented with uveitis associated with multiple sclerosis.
Methods:
Retrospective review of 20 patients (38 eyes).
Results:
The most frequent ocular finding was multifocal elongated retinal perivenous “sheathing” with focal vascular leakage on fundus fluorescein angiography in 29 eyes followed by vitreous snowballs and debris in 26 eyes, anterior chamber inflammation in 15 eyes, mutton-fat keratic precipitates in 14 eyes, posterior synechiae in 13 eyes, cystoid macular edema in 9 eyes, iris nodules in 4 eyes, and optic neuritis in 3 eyes. Patients with cystoid macular edema were treated successfully with systemic corticosteroids combined with mycophenolate mofetil. Ocular complications were cataract in 6 eyes, glaucoma in 2 eyes and vitreous hemorrhage in 1 eye.
Conclusions:
Multifocal elongated retinal perivenous “sheathing” with focal vascular leakage on fundus fluorescein angiography is the most frequent finding in uveitis associated with multiple sclerosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Child</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Macular Edema - diagnostic imaging</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Methylprednisolone - therapeutic use</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis - complications</subject><subject>Multiple Sclerosis - diagnostic imaging</subject><subject>Multiple Sclerosis - drug therapy</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Optic Neuritis - diagnostic imaging</subject><subject>Retrospective Studies</subject><subject>Slit Lamp Microscopy</subject><subject>Tomography, Optical Coherence</subject><subject>Uveitis - complications</subject><subject>Uveitis - diagnostic imaging</subject><subject>Uveitis - drug therapy</subject><subject>Uveitis - physiopathology</subject><subject>Visual Acuity - physiology</subject><subject>Young Adult</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UEtLxDAQDqK46-rdk-QPVDNpmrRHWXxBwYueS5pM1ix90bSK_94sVQ-Cl5lh5nswHyGXwK4BlLoB4EwqHmvBhJTqiKxBcZFIBvI4zvGQHO4rchbCnrGIE_yUrFLOoEhTtSbltvGdN7qhznfWd7tAdWdpP0-mbzHQ3tH5Hf3k4z6E3ng9oaUffnqj7dxMfmiQBtPg2AcfzsmJ003Ai---Ia_3dy_bx6R8fnja3paJiZ5TYlHlFiRDkWtQmQIlLQPLM2NBpDY2Wecyzx1K6aDODBe504yDQygKYdINYYuuibZhRFcNo2_1-FkBqw7BVH-DiZSrhTLMdYv2l_CTRAQkCyDoHVb7fh67-ML_gl8PUGsS</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>AlBloushi, Abdulrahman F</creator><creator>Dheyab, Abdulsalam M</creator><creator>Al-Swaina, Nayef F</creator><creator>Al-Obailan, Majed</creator><creator>Daif, Abdul-kader</creator><creator>Abu El-Asrar, Ahmed M</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-2226-8617</orcidid><orcidid>https://orcid.org/0000-0003-1104-9208</orcidid></search><sort><creationdate>202103</creationdate><title>Clinical findings and outcomes of uveitis associated with multiple sclerosis</title><author>AlBloushi, Abdulrahman F ; Dheyab, Abdulsalam M ; Al-Swaina, Nayef F ; Al-Obailan, Majed ; Daif, Abdul-kader ; Abu El-Asrar, Ahmed M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-de78d160e48a1757176d01d25cd143d5cd6b8688fe66f1b5c248fa021fe1994c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Child</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Macular Edema - diagnostic imaging</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Methylprednisolone - therapeutic use</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis - complications</topic><topic>Multiple Sclerosis - diagnostic imaging</topic><topic>Multiple Sclerosis - drug therapy</topic><topic>Multiple Sclerosis - physiopathology</topic><topic>Optic Neuritis - diagnostic imaging</topic><topic>Retrospective Studies</topic><topic>Slit Lamp Microscopy</topic><topic>Tomography, Optical Coherence</topic><topic>Uveitis - complications</topic><topic>Uveitis - diagnostic imaging</topic><topic>Uveitis - drug therapy</topic><topic>Uveitis - physiopathology</topic><topic>Visual Acuity - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AlBloushi, Abdulrahman F</creatorcontrib><creatorcontrib>Dheyab, Abdulsalam M</creatorcontrib><creatorcontrib>Al-Swaina, Nayef F</creatorcontrib><creatorcontrib>Al-Obailan, Majed</creatorcontrib><creatorcontrib>Daif, Abdul-kader</creatorcontrib><creatorcontrib>Abu El-Asrar, Ahmed M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AlBloushi, Abdulrahman F</au><au>Dheyab, Abdulsalam M</au><au>Al-Swaina, Nayef F</au><au>Al-Obailan, Majed</au><au>Daif, Abdul-kader</au><au>Abu El-Asrar, Ahmed M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical findings and outcomes of uveitis associated with multiple sclerosis</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>Eur J Ophthalmol</addtitle><date>2021-03</date><risdate>2021</risdate><volume>31</volume><issue>2</issue><spage>482</spage><epage>490</epage><pages>482-490</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>Purpose:
To describe the clinical findings and outcomes in patients who presented with uveitis associated with multiple sclerosis.
Methods:
Retrospective review of 20 patients (38 eyes).
Results:
The most frequent ocular finding was multifocal elongated retinal perivenous “sheathing” with focal vascular leakage on fundus fluorescein angiography in 29 eyes followed by vitreous snowballs and debris in 26 eyes, anterior chamber inflammation in 15 eyes, mutton-fat keratic precipitates in 14 eyes, posterior synechiae in 13 eyes, cystoid macular edema in 9 eyes, iris nodules in 4 eyes, and optic neuritis in 3 eyes. Patients with cystoid macular edema were treated successfully with systemic corticosteroids combined with mycophenolate mofetil. Ocular complications were cataract in 6 eyes, glaucoma in 2 eyes and vitreous hemorrhage in 1 eye.
Conclusions:
Multifocal elongated retinal perivenous “sheathing” with focal vascular leakage on fundus fluorescein angiography is the most frequent finding in uveitis associated with multiple sclerosis.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>32019337</pmid><doi>10.1177/1120672120904667</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2226-8617</orcidid><orcidid>https://orcid.org/0000-0003-1104-9208</orcidid></addata></record> |
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| source | Access via SAGE; MEDLINE |
| subjects | Adolescent Adult Child Female Fluorescein Angiography Glucocorticoids - therapeutic use Humans Macular Edema - diagnostic imaging Magnetic Resonance Imaging Male Methylprednisolone - therapeutic use Middle Aged Multiple Sclerosis - complications Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - drug therapy Multiple Sclerosis - physiopathology Optic Neuritis - diagnostic imaging Retrospective Studies Slit Lamp Microscopy Tomography, Optical Coherence Uveitis - complications Uveitis - diagnostic imaging Uveitis - drug therapy Uveitis - physiopathology Visual Acuity - physiology Young Adult |
| title | Clinical findings and outcomes of uveitis associated with multiple sclerosis |
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