The value of prednisolone acetate provocative test before intravitreal triamcinolone acetonide injections
Purpose: The aim of this study was to investigate the diagnostic value of a topical prednisolone acetate 1% provocative test for steroid-induced ocular hypertension before intravitreal triamcinolone acetonide injection. Methods: This is a prospective, single-center, randomized controlled study at Ka...
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| Veröffentlicht in: | European journal of ophthalmology 2020-07, Vol.30 (4), p.730-737 |
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| creator | Saady, Aya Mohammed Fouad, Heba M Abdullatif, Abdussalam M Helmy, Youssef A H Macky, Tamer A Mansour, Khaled |
| description | Purpose:
The aim of this study was to investigate the diagnostic value of a topical prednisolone acetate 1% provocative test for steroid-induced ocular hypertension before intravitreal triamcinolone acetonide injection.
Methods:
This is a prospective, single-center, randomized controlled study at Kasr El Aini Hospital, Cairo University. Patients scheduled for intravitreal triamcinolone acetonide were enrolled and randomly allocated in a ratio 2:1 to either Group A: received prednisolone acetate provocative test and those who did not develop SIOH proceeded with intravitreal triamcinolone acetonide or Group B: did not receive prednisolone acetate provocative test and proceeded directly to intravitreal triamcinolone acetonide. Intraocular pressures were measured weekly for 4 weeks following intravitreal triamcinolone acetonide. Steroid-induced ocular hypertension is defined as intraocular pressure increase of 5 mmHg or more from baseline after prednisolone acetate provocative test or intravitreal triamcinolone acetonide.
Results:
A total of 66 eyes (66 patients) were included. Of which, 10 eyes (23.8%) showed prednisolone acetate provocative test steroid-induced ocular hypertension during the 4-week period. Intravitreal triamcinolone acetonide steroid-induced ocular hypertension was less likely to develop in Group A (prednisolone acetate provocative test non-steroid-induced ocular hypertension, n = 32, 31.25%) than in group B (n = 24, 54.2%) (p = 0.006, odds ratio: 0.178, 95% CI: 0.53–0.596). Our test achieved a negative predictive value of 68.75%.
Conclusion:
The topical prednisolone acetate provocative test may be a useful method to predict a steroid-induced ocular hypertension following intravitreal triamcinolone acetonide. |
| doi_str_mv | 10.1177/1120672119842731 |
| format | Article |
| fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1177_1120672119842731</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1120672119842731</sage_id><sourcerecordid>10.1177_1120672119842731</sourcerecordid><originalsourceid>FETCH-LOGICAL-c290t-26ff28a3c2cfb73aafd278567611bc1fd35cefcc1d32b0c896853444104764863</originalsourceid><addsrcrecordid>eNp1kE9LAzEQxYMotlbvniRfYDWTpMnuUYpWoeClnpdsdqIp201J0gW_vVvqHxA8zTDv_R7MI-Qa2C2A1ncAnCnNAapSci3ghExBc1koBup03Ee5OOgTcpHShjHOKsnPyUSwSmuh9ZT49TvSwXR7pMHRXcS29yl0oUdqLGaTcTyGIViT_YA0Y8q0QRciUt_naAafI5qO5ujN1vr-Fw29bw-mDdrsQ58uyZkzXcKrrzkjr48P68VTsXpZPi_uV4XlFcsFV87x0gjLrWu0MMa1XJdzpRVAY8G1Ym7RWQut4A2zZaXKuZBSApNayVKJGWHHXBtDShFdvYt-a-JHDaw-tFb_bW1Ebo7Ibt9ssf0BvmsaDcXRkMwb1puwj_34wv-Bn306dr4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The value of prednisolone acetate provocative test before intravitreal triamcinolone acetonide injections</title><source>Access via SAGE</source><source>MEDLINE</source><creator>Saady, Aya Mohammed ; Fouad, Heba M ; Abdullatif, Abdussalam M ; Helmy, Youssef A H ; Macky, Tamer A ; Mansour, Khaled</creator><creatorcontrib>Saady, Aya Mohammed ; Fouad, Heba M ; Abdullatif, Abdussalam M ; Helmy, Youssef A H ; Macky, Tamer A ; Mansour, Khaled</creatorcontrib><description>Purpose:
The aim of this study was to investigate the diagnostic value of a topical prednisolone acetate 1% provocative test for steroid-induced ocular hypertension before intravitreal triamcinolone acetonide injection.
Methods:
This is a prospective, single-center, randomized controlled study at Kasr El Aini Hospital, Cairo University. Patients scheduled for intravitreal triamcinolone acetonide were enrolled and randomly allocated in a ratio 2:1 to either Group A: received prednisolone acetate provocative test and those who did not develop SIOH proceeded with intravitreal triamcinolone acetonide or Group B: did not receive prednisolone acetate provocative test and proceeded directly to intravitreal triamcinolone acetonide. Intraocular pressures were measured weekly for 4 weeks following intravitreal triamcinolone acetonide. Steroid-induced ocular hypertension is defined as intraocular pressure increase of 5 mmHg or more from baseline after prednisolone acetate provocative test or intravitreal triamcinolone acetonide.
Results:
A total of 66 eyes (66 patients) were included. Of which, 10 eyes (23.8%) showed prednisolone acetate provocative test steroid-induced ocular hypertension during the 4-week period. Intravitreal triamcinolone acetonide steroid-induced ocular hypertension was less likely to develop in Group A (prednisolone acetate provocative test non-steroid-induced ocular hypertension, n = 32, 31.25%) than in group B (n = 24, 54.2%) (p = 0.006, odds ratio: 0.178, 95% CI: 0.53–0.596). Our test achieved a negative predictive value of 68.75%.
Conclusion:
The topical prednisolone acetate provocative test may be a useful method to predict a steroid-induced ocular hypertension following intravitreal triamcinolone acetonide.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.1177/1120672119842731</identifier><identifier>PMID: 30977377</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Administration, Ophthalmic ; Adult ; Aged ; Anti-Inflammatory Agents - administration & dosage ; Female ; Glucocorticoids - therapeutic use ; Humans ; Intraocular Pressure - drug effects ; Intravitreal Injections ; Macular Edema - drug therapy ; Macular Edema - etiology ; Male ; Middle Aged ; Ocular Hypertension - chemically induced ; Ocular Hypertension - diagnosis ; Ophthalmic Solutions ; Prednisolone - administration & dosage ; Prednisolone - analogs & derivatives ; Prospective Studies ; Retinal Vein Occlusion - complications ; Retinal Vein Occlusion - drug therapy ; Triamcinolone Acetonide - therapeutic use</subject><ispartof>European journal of ophthalmology, 2020-07, Vol.30 (4), p.730-737</ispartof><rights>The Author(s) 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c290t-26ff28a3c2cfb73aafd278567611bc1fd35cefcc1d32b0c896853444104764863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1120672119842731$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1120672119842731$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30977377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saady, Aya Mohammed</creatorcontrib><creatorcontrib>Fouad, Heba M</creatorcontrib><creatorcontrib>Abdullatif, Abdussalam M</creatorcontrib><creatorcontrib>Helmy, Youssef A H</creatorcontrib><creatorcontrib>Macky, Tamer A</creatorcontrib><creatorcontrib>Mansour, Khaled</creatorcontrib><title>The value of prednisolone acetate provocative test before intravitreal triamcinolone acetonide injections</title><title>European journal of ophthalmology</title><addtitle>Eur J Ophthalmol</addtitle><description>Purpose:
The aim of this study was to investigate the diagnostic value of a topical prednisolone acetate 1% provocative test for steroid-induced ocular hypertension before intravitreal triamcinolone acetonide injection.
Methods:
This is a prospective, single-center, randomized controlled study at Kasr El Aini Hospital, Cairo University. Patients scheduled for intravitreal triamcinolone acetonide were enrolled and randomly allocated in a ratio 2:1 to either Group A: received prednisolone acetate provocative test and those who did not develop SIOH proceeded with intravitreal triamcinolone acetonide or Group B: did not receive prednisolone acetate provocative test and proceeded directly to intravitreal triamcinolone acetonide. Intraocular pressures were measured weekly for 4 weeks following intravitreal triamcinolone acetonide. Steroid-induced ocular hypertension is defined as intraocular pressure increase of 5 mmHg or more from baseline after prednisolone acetate provocative test or intravitreal triamcinolone acetonide.
Results:
A total of 66 eyes (66 patients) were included. Of which, 10 eyes (23.8%) showed prednisolone acetate provocative test steroid-induced ocular hypertension during the 4-week period. Intravitreal triamcinolone acetonide steroid-induced ocular hypertension was less likely to develop in Group A (prednisolone acetate provocative test non-steroid-induced ocular hypertension, n = 32, 31.25%) than in group B (n = 24, 54.2%) (p = 0.006, odds ratio: 0.178, 95% CI: 0.53–0.596). Our test achieved a negative predictive value of 68.75%.
Conclusion:
The topical prednisolone acetate provocative test may be a useful method to predict a steroid-induced ocular hypertension following intravitreal triamcinolone acetonide.</description><subject>Administration, Ophthalmic</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Female</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Intraocular Pressure - drug effects</subject><subject>Intravitreal Injections</subject><subject>Macular Edema - drug therapy</subject><subject>Macular Edema - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Ocular Hypertension - chemically induced</subject><subject>Ocular Hypertension - diagnosis</subject><subject>Ophthalmic Solutions</subject><subject>Prednisolone - administration & dosage</subject><subject>Prednisolone - analogs & derivatives</subject><subject>Prospective Studies</subject><subject>Retinal Vein Occlusion - complications</subject><subject>Retinal Vein Occlusion - drug therapy</subject><subject>Triamcinolone Acetonide - therapeutic use</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE9LAzEQxYMotlbvniRfYDWTpMnuUYpWoeClnpdsdqIp201J0gW_vVvqHxA8zTDv_R7MI-Qa2C2A1ncAnCnNAapSci3ghExBc1koBup03Ee5OOgTcpHShjHOKsnPyUSwSmuh9ZT49TvSwXR7pMHRXcS29yl0oUdqLGaTcTyGIViT_YA0Y8q0QRciUt_naAafI5qO5ujN1vr-Fw29bw-mDdrsQ58uyZkzXcKrrzkjr48P68VTsXpZPi_uV4XlFcsFV87x0gjLrWu0MMa1XJdzpRVAY8G1Ym7RWQut4A2zZaXKuZBSApNayVKJGWHHXBtDShFdvYt-a-JHDaw-tFb_bW1Ebo7Ibt9ssf0BvmsaDcXRkMwb1puwj_34wv-Bn306dr4</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Saady, Aya Mohammed</creator><creator>Fouad, Heba M</creator><creator>Abdullatif, Abdussalam M</creator><creator>Helmy, Youssef A H</creator><creator>Macky, Tamer A</creator><creator>Mansour, Khaled</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>202007</creationdate><title>The value of prednisolone acetate provocative test before intravitreal triamcinolone acetonide injections</title><author>Saady, Aya Mohammed ; Fouad, Heba M ; Abdullatif, Abdussalam M ; Helmy, Youssef A H ; Macky, Tamer A ; Mansour, Khaled</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c290t-26ff28a3c2cfb73aafd278567611bc1fd35cefcc1d32b0c896853444104764863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Administration, Ophthalmic</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Female</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Intraocular Pressure - drug effects</topic><topic>Intravitreal Injections</topic><topic>Macular Edema - drug therapy</topic><topic>Macular Edema - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Ocular Hypertension - chemically induced</topic><topic>Ocular Hypertension - diagnosis</topic><topic>Ophthalmic Solutions</topic><topic>Prednisolone - administration & dosage</topic><topic>Prednisolone - analogs & derivatives</topic><topic>Prospective Studies</topic><topic>Retinal Vein Occlusion - complications</topic><topic>Retinal Vein Occlusion - drug therapy</topic><topic>Triamcinolone Acetonide - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saady, Aya Mohammed</creatorcontrib><creatorcontrib>Fouad, Heba M</creatorcontrib><creatorcontrib>Abdullatif, Abdussalam M</creatorcontrib><creatorcontrib>Helmy, Youssef A H</creatorcontrib><creatorcontrib>Macky, Tamer A</creatorcontrib><creatorcontrib>Mansour, Khaled</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saady, Aya Mohammed</au><au>Fouad, Heba M</au><au>Abdullatif, Abdussalam M</au><au>Helmy, Youssef A H</au><au>Macky, Tamer A</au><au>Mansour, Khaled</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The value of prednisolone acetate provocative test before intravitreal triamcinolone acetonide injections</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>Eur J Ophthalmol</addtitle><date>2020-07</date><risdate>2020</risdate><volume>30</volume><issue>4</issue><spage>730</spage><epage>737</epage><pages>730-737</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>Purpose:
The aim of this study was to investigate the diagnostic value of a topical prednisolone acetate 1% provocative test for steroid-induced ocular hypertension before intravitreal triamcinolone acetonide injection.
Methods:
This is a prospective, single-center, randomized controlled study at Kasr El Aini Hospital, Cairo University. Patients scheduled for intravitreal triamcinolone acetonide were enrolled and randomly allocated in a ratio 2:1 to either Group A: received prednisolone acetate provocative test and those who did not develop SIOH proceeded with intravitreal triamcinolone acetonide or Group B: did not receive prednisolone acetate provocative test and proceeded directly to intravitreal triamcinolone acetonide. Intraocular pressures were measured weekly for 4 weeks following intravitreal triamcinolone acetonide. Steroid-induced ocular hypertension is defined as intraocular pressure increase of 5 mmHg or more from baseline after prednisolone acetate provocative test or intravitreal triamcinolone acetonide.
Results:
A total of 66 eyes (66 patients) were included. Of which, 10 eyes (23.8%) showed prednisolone acetate provocative test steroid-induced ocular hypertension during the 4-week period. Intravitreal triamcinolone acetonide steroid-induced ocular hypertension was less likely to develop in Group A (prednisolone acetate provocative test non-steroid-induced ocular hypertension, n = 32, 31.25%) than in group B (n = 24, 54.2%) (p = 0.006, odds ratio: 0.178, 95% CI: 0.53–0.596). Our test achieved a negative predictive value of 68.75%.
Conclusion:
The topical prednisolone acetate provocative test may be a useful method to predict a steroid-induced ocular hypertension following intravitreal triamcinolone acetonide.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>30977377</pmid><doi>10.1177/1120672119842731</doi><tpages>8</tpages></addata></record> |
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| subjects | Administration, Ophthalmic Adult Aged Anti-Inflammatory Agents - administration & dosage Female Glucocorticoids - therapeutic use Humans Intraocular Pressure - drug effects Intravitreal Injections Macular Edema - drug therapy Macular Edema - etiology Male Middle Aged Ocular Hypertension - chemically induced Ocular Hypertension - diagnosis Ophthalmic Solutions Prednisolone - administration & dosage Prednisolone - analogs & derivatives Prospective Studies Retinal Vein Occlusion - complications Retinal Vein Occlusion - drug therapy Triamcinolone Acetonide - therapeutic use |
| title | The value of prednisolone acetate provocative test before intravitreal triamcinolone acetonide injections |
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