Comparison of dose-related ocular side effects during systemic isotretinoin administration
To compare the effects of high- (Group 1) and low-dose (Group 2) isotretinoin treatments for acne vulgaris on lacrimal functions and other ocular complications. Twenty-six patients receiving high-dose (>0.5 mg/kg per day) systemic isotretinoin treatment and 25 patients treated with low-dose syste...
Gespeichert in:
| Veröffentlicht in: | European journal of ophthalmology 2009-03, Vol.19 (2), p.196-200 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 200 |
|---|---|
| container_issue | 2 |
| container_start_page | 196 |
| container_title | European journal of ophthalmology |
| container_volume | 19 |
| creator | Cumurcu, Tongabay Sezer, Engin Kilic, Rasit Bulut, Yunus |
| description | To compare the effects of high- (Group 1) and low-dose (Group 2) isotretinoin treatments for acne vulgaris on lacrimal functions and other ocular complications.
Twenty-six patients receiving high-dose (>0.5 mg/kg per day) systemic isotretinoin treatment and 25 patients treated with low-dose systemic isotretinoin ( 0.05). Although BUT did not differ significantly between the two groups before treatment (p >0.05), there was a statistically significant decrease in BUT in Group 1 when compared with Group 2 at days 45 and 90 of treatment (p 0.05). No difference in Staphylococcus aureus colonization was detected between the two groups at days 45 and 90 of treatment (p >0.05).
During systemic isotretinoin treatment, eye dryness was related to the dose used, at least during the period of treatment. Conversely, the rate of conjunctival S aureus colonization was unrelated to the dose of isotretinoin. |
| doi_str_mv | 10.1177/112067210901900204 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1177_112067210901900204</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19253234</sourcerecordid><originalsourceid>FETCH-LOGICAL-c301t-36031fba6b64f43154622cb7455d9740f5277af4c6f5be75e34e09ace77a2b2b3</originalsourceid><addsrcrecordid>eNplkE1LAzEQQIMotlb_gAfJH1jN5JM9SvELCl704mVJshOJdDclyR76793SggdPMwzvzeERcgvsHsCYBwDOtOHAWgYtY5zJM7IEw2WjGejzeZ-B5kAsyFUpPweklfySLKDlSnAhl-RrnYadzbGkkaZA-1Swybi1FXua_LS1mZbYI8UQ0NdC-ynH8ZuWfak4RE9nsWascUxxpLYf4hhLzbbGNF6Ti2C3BW9Oc0U-n58-1q_N5v3lbf24abxgUBuhmYDgrHZaBilASc25d0Yq1bdGsqC4MTZIr4NyaBQKiay1Hucrd9yJFeHHvz6nUjKGbpfjYPO-A9YdQnX_Q83S3VHaTW7A_k85lRG_65NkdA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Comparison of dose-related ocular side effects during systemic isotretinoin administration</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><creator>Cumurcu, Tongabay ; Sezer, Engin ; Kilic, Rasit ; Bulut, Yunus</creator><creatorcontrib>Cumurcu, Tongabay ; Sezer, Engin ; Kilic, Rasit ; Bulut, Yunus</creatorcontrib><description>To compare the effects of high- (Group 1) and low-dose (Group 2) isotretinoin treatments for acne vulgaris on lacrimal functions and other ocular complications.
Twenty-six patients receiving high-dose (>0.5 mg/kg per day) systemic isotretinoin treatment and 25 patients treated with low-dose systemic isotretinoin (<0.5 mg/kg per day) underwent complete ophthalmologic assessment of both eyes before treatment, at days 45 and 90 of treatment, and 1 month after the completion of treatment, together with a microbiologic evaluation of conjunctival flora, tear film break-up time (BUT), and anesthetized Schirmer test of the right eye of each patient.
When the results of the anesthetized Schirmer test for Groups 1 and 2 were compared (pretreatment, days 45 and 90 of treatment, and 1 month after treatment), there was no statistically significant difference between the groups (p > 0.05). Although BUT did not differ significantly between the two groups before treatment (p >0.05), there was a statistically significant decrease in BUT in Group 1 when compared with Group 2 at days 45 and 90 of treatment (p <0.05). One month after the completion of treatment, there was no difference in BUT between the two groups (p >0.05). No difference in Staphylococcus aureus colonization was detected between the two groups at days 45 and 90 of treatment (p >0.05).
During systemic isotretinoin treatment, eye dryness was related to the dose used, at least during the period of treatment. Conversely, the rate of conjunctival S aureus colonization was unrelated to the dose of isotretinoin.</description><identifier>ISSN: 1120-6721</identifier><identifier>EISSN: 1724-6016</identifier><identifier>DOI: 10.1177/112067210901900204</identifier><identifier>PMID: 19253234</identifier><language>eng</language><publisher>United States</publisher><subject>Acne Vulgaris - drug therapy ; Administration, Oral ; Adult ; Colony Count, Microbial ; Conjunctiva - microbiology ; Dermatologic Agents - administration & dosage ; Dermatologic Agents - adverse effects ; Dry Eye Syndromes - physiopathology ; Eye Diseases - chemically induced ; Eye Diseases - metabolism ; Eye Diseases - physiopathology ; Female ; Humans ; Isotretinoin - administration & dosage ; Isotretinoin - adverse effects ; Lacrimal Apparatus - drug effects ; Lacrimal Apparatus - metabolism ; Lacrimal Apparatus - physiopathology ; Male ; Staphylococcus aureus - physiology ; Tears - secretion</subject><ispartof>European journal of ophthalmology, 2009-03, Vol.19 (2), p.196-200</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-36031fba6b64f43154622cb7455d9740f5277af4c6f5be75e34e09ace77a2b2b3</citedby><cites>FETCH-LOGICAL-c301t-36031fba6b64f43154622cb7455d9740f5277af4c6f5be75e34e09ace77a2b2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19253234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cumurcu, Tongabay</creatorcontrib><creatorcontrib>Sezer, Engin</creatorcontrib><creatorcontrib>Kilic, Rasit</creatorcontrib><creatorcontrib>Bulut, Yunus</creatorcontrib><title>Comparison of dose-related ocular side effects during systemic isotretinoin administration</title><title>European journal of ophthalmology</title><addtitle>Eur J Ophthalmol</addtitle><description>To compare the effects of high- (Group 1) and low-dose (Group 2) isotretinoin treatments for acne vulgaris on lacrimal functions and other ocular complications.
Twenty-six patients receiving high-dose (>0.5 mg/kg per day) systemic isotretinoin treatment and 25 patients treated with low-dose systemic isotretinoin (<0.5 mg/kg per day) underwent complete ophthalmologic assessment of both eyes before treatment, at days 45 and 90 of treatment, and 1 month after the completion of treatment, together with a microbiologic evaluation of conjunctival flora, tear film break-up time (BUT), and anesthetized Schirmer test of the right eye of each patient.
When the results of the anesthetized Schirmer test for Groups 1 and 2 were compared (pretreatment, days 45 and 90 of treatment, and 1 month after treatment), there was no statistically significant difference between the groups (p > 0.05). Although BUT did not differ significantly between the two groups before treatment (p >0.05), there was a statistically significant decrease in BUT in Group 1 when compared with Group 2 at days 45 and 90 of treatment (p <0.05). One month after the completion of treatment, there was no difference in BUT between the two groups (p >0.05). No difference in Staphylococcus aureus colonization was detected between the two groups at days 45 and 90 of treatment (p >0.05).
During systemic isotretinoin treatment, eye dryness was related to the dose used, at least during the period of treatment. Conversely, the rate of conjunctival S aureus colonization was unrelated to the dose of isotretinoin.</description><subject>Acne Vulgaris - drug therapy</subject><subject>Administration, Oral</subject><subject>Adult</subject><subject>Colony Count, Microbial</subject><subject>Conjunctiva - microbiology</subject><subject>Dermatologic Agents - administration & dosage</subject><subject>Dermatologic Agents - adverse effects</subject><subject>Dry Eye Syndromes - physiopathology</subject><subject>Eye Diseases - chemically induced</subject><subject>Eye Diseases - metabolism</subject><subject>Eye Diseases - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Isotretinoin - administration & dosage</subject><subject>Isotretinoin - adverse effects</subject><subject>Lacrimal Apparatus - drug effects</subject><subject>Lacrimal Apparatus - metabolism</subject><subject>Lacrimal Apparatus - physiopathology</subject><subject>Male</subject><subject>Staphylococcus aureus - physiology</subject><subject>Tears - secretion</subject><issn>1120-6721</issn><issn>1724-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkE1LAzEQQIMotlb_gAfJH1jN5JM9SvELCl704mVJshOJdDclyR76793SggdPMwzvzeERcgvsHsCYBwDOtOHAWgYtY5zJM7IEw2WjGejzeZ-B5kAsyFUpPweklfySLKDlSnAhl-RrnYadzbGkkaZA-1Swybi1FXua_LS1mZbYI8UQ0NdC-ynH8ZuWfak4RE9nsWascUxxpLYf4hhLzbbGNF6Ti2C3BW9Oc0U-n58-1q_N5v3lbf24abxgUBuhmYDgrHZaBilASc25d0Yq1bdGsqC4MTZIr4NyaBQKiay1Hucrd9yJFeHHvz6nUjKGbpfjYPO-A9YdQnX_Q83S3VHaTW7A_k85lRG_65NkdA</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Cumurcu, Tongabay</creator><creator>Sezer, Engin</creator><creator>Kilic, Rasit</creator><creator>Bulut, Yunus</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20090301</creationdate><title>Comparison of dose-related ocular side effects during systemic isotretinoin administration</title><author>Cumurcu, Tongabay ; Sezer, Engin ; Kilic, Rasit ; Bulut, Yunus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-36031fba6b64f43154622cb7455d9740f5277af4c6f5be75e34e09ace77a2b2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acne Vulgaris - drug therapy</topic><topic>Administration, Oral</topic><topic>Adult</topic><topic>Colony Count, Microbial</topic><topic>Conjunctiva - microbiology</topic><topic>Dermatologic Agents - administration & dosage</topic><topic>Dermatologic Agents - adverse effects</topic><topic>Dry Eye Syndromes - physiopathology</topic><topic>Eye Diseases - chemically induced</topic><topic>Eye Diseases - metabolism</topic><topic>Eye Diseases - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Isotretinoin - administration & dosage</topic><topic>Isotretinoin - adverse effects</topic><topic>Lacrimal Apparatus - drug effects</topic><topic>Lacrimal Apparatus - metabolism</topic><topic>Lacrimal Apparatus - physiopathology</topic><topic>Male</topic><topic>Staphylococcus aureus - physiology</topic><topic>Tears - secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cumurcu, Tongabay</creatorcontrib><creatorcontrib>Sezer, Engin</creatorcontrib><creatorcontrib>Kilic, Rasit</creatorcontrib><creatorcontrib>Bulut, Yunus</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>European journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cumurcu, Tongabay</au><au>Sezer, Engin</au><au>Kilic, Rasit</au><au>Bulut, Yunus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of dose-related ocular side effects during systemic isotretinoin administration</atitle><jtitle>European journal of ophthalmology</jtitle><addtitle>Eur J Ophthalmol</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>19</volume><issue>2</issue><spage>196</spage><epage>200</epage><pages>196-200</pages><issn>1120-6721</issn><eissn>1724-6016</eissn><abstract>To compare the effects of high- (Group 1) and low-dose (Group 2) isotretinoin treatments for acne vulgaris on lacrimal functions and other ocular complications.
Twenty-six patients receiving high-dose (>0.5 mg/kg per day) systemic isotretinoin treatment and 25 patients treated with low-dose systemic isotretinoin (<0.5 mg/kg per day) underwent complete ophthalmologic assessment of both eyes before treatment, at days 45 and 90 of treatment, and 1 month after the completion of treatment, together with a microbiologic evaluation of conjunctival flora, tear film break-up time (BUT), and anesthetized Schirmer test of the right eye of each patient.
When the results of the anesthetized Schirmer test for Groups 1 and 2 were compared (pretreatment, days 45 and 90 of treatment, and 1 month after treatment), there was no statistically significant difference between the groups (p > 0.05). Although BUT did not differ significantly between the two groups before treatment (p >0.05), there was a statistically significant decrease in BUT in Group 1 when compared with Group 2 at days 45 and 90 of treatment (p <0.05). One month after the completion of treatment, there was no difference in BUT between the two groups (p >0.05). No difference in Staphylococcus aureus colonization was detected between the two groups at days 45 and 90 of treatment (p >0.05).
During systemic isotretinoin treatment, eye dryness was related to the dose used, at least during the period of treatment. Conversely, the rate of conjunctival S aureus colonization was unrelated to the dose of isotretinoin.</abstract><cop>United States</cop><pmid>19253234</pmid><doi>10.1177/112067210901900204</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1120-6721 |
| ispartof | European journal of ophthalmology, 2009-03, Vol.19 (2), p.196-200 |
| issn | 1120-6721 1724-6016 |
| language | eng |
| recordid | cdi_crossref_primary_10_1177_112067210901900204 |
| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Acne Vulgaris - drug therapy Administration, Oral Adult Colony Count, Microbial Conjunctiva - microbiology Dermatologic Agents - administration & dosage Dermatologic Agents - adverse effects Dry Eye Syndromes - physiopathology Eye Diseases - chemically induced Eye Diseases - metabolism Eye Diseases - physiopathology Female Humans Isotretinoin - administration & dosage Isotretinoin - adverse effects Lacrimal Apparatus - drug effects Lacrimal Apparatus - metabolism Lacrimal Apparatus - physiopathology Male Staphylococcus aureus - physiology Tears - secretion |
| title | Comparison of dose-related ocular side effects during systemic isotretinoin administration |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T23%3A32%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20dose-related%20ocular%20side%20effects%20during%20systemic%20isotretinoin%20administration&rft.jtitle=European%20journal%20of%20ophthalmology&rft.au=Cumurcu,%20Tongabay&rft.date=2009-03-01&rft.volume=19&rft.issue=2&rft.spage=196&rft.epage=200&rft.pages=196-200&rft.issn=1120-6721&rft.eissn=1724-6016&rft_id=info:doi/10.1177/112067210901900204&rft_dat=%3Cpubmed_cross%3E19253234%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/19253234&rfr_iscdi=true |