Monitoring Compound-Related Effects on Coagulability in Rats and Cynomolgus and Rhesus Monkeys by Thrombin Generation Kinetic Measurement

Thrombin generation assay (TGA) is a sensitive method for the assessment of the global clotting potential of plasma. This kinetic assay can detect both hypocoagulable and hypercoagulable conditions: delayed or reduced thrombin generation leading to a prolonged clotting time, or induced thrombin acti...

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Veröffentlicht in:	International journal of toxicology 2020-05, Vol.39 (3), p.207-217
Hauptverfasser:	Poitout-Belissent, F., Culang, D., Poulin, D., Samadfan, R., Cotton, S., Bédard, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Coagulation - drug effects Blood Coagulation Tests Coagulants - toxicity Female Kinetics Lipopolysaccharides - toxicity Macaca fascicularis Macaca mulatta Male Rats, Sprague-Dawley Thrombin - biosynthesis
Online-Zugang:	Volltext
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