Solution Phase Synthesis of Chemical Libraries for Lead Discovery
By integrating advanced computational design and synthesis, a series of structurally diverse reaction products based on three core scaffolds were prepared by a propietary high throughput synthesis method. Incorporation of auto-mated work stations and sample handling techniques allowed for the produc...
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| Veröffentlicht in: | Journal of biomolecular screening 1996-06, Vol.1 (4), p.179-186 |
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| Format: | Artikel |
| Sprache: | eng |
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| container_end_page | 186 |
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| container_issue | 4 |
| container_start_page | 179 |
| container_title | Journal of biomolecular screening |
| container_volume | 1 |
| creator | Garr, Cheryl D. Peterson, John R. Schultz, Lauri Oliver, Amy R. Underiner, Ted L. Cramer, Richard D. Ferguson, Allan M. Lawless, Michael S. Patterson, David E. |
| description | By integrating advanced computational design and synthesis, a series of structurally diverse reaction products based on three core scaffolds were prepared by a propietary high throughput synthesis method. Incorporation of auto-mated work stations and sample handling techniques allowed for the production of more than 20,000 compounds in a relatively short time. A method to efficiently obtain quantitative and qualitative analytical data on these compounds was developed. Structural comparison of the individual members of this library with a database of clinical drug candidates revealed a significant degree of similarity based on Tanimoto coefficients. |
| doi_str_mv | 10.1177/108705719600100404 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1087-0571 |
| ispartof | Journal of biomolecular screening, 1996-06, Vol.1 (4), p.179-186 |
| issn | 1087-0571 2472-5552 1552-454X |
| language | eng |
| recordid | cdi_crossref_primary_10_1177_108705719600100404 |
| source | Alma/SFX Local Collection |
| title | Solution Phase Synthesis of Chemical Libraries for Lead Discovery |
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