Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-HT2A Receptors and Identification of Active Compounds by High-Throughput Screening

G protein–coupled receptors (GPCRs) exist as collections of conformations in equilibrium, and the efficacy of drugs has been proposed to be associated with their absolute and relative affinities for these different conformations. The serotonin 2A (5-HT2A) receptor regulates multiple physiological fu...

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Veröffentlicht in:	Journal of biomolecular screening 2016-09, Vol.21 (8), p.816-823
Hauptverfasser:	Iglesias, Alba, Lage, Sonia, Cadavid, Maria Isabel, Loza, Maria Isabel, Brea, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Antipsychotic Agents - isolation & purification Antipsychotic Agents - therapeutic use Binding Sites Drug Evaluation, Preclinical High-Throughput Screening Assays - methods Humans Ligands Phospholipases A2 - metabolism Receptors, Serotonin, 5-HT2 - metabolism Schizophrenia - drug therapy Schizophrenia - metabolism Serotonin 5-HT2 Receptor Antagonists - isolation & purification Serotonin 5-HT2 Receptor Antagonists - metabolism Signal Transduction Type C Phospholipases - metabolism
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