NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaA

Nonessential enzymes in the staphylococcal wall teichoic acid (WTA) pathway serve as highly validated β-lactam potentiation targets. MnaA (UDP-GlcNAc 2-epimerase) plays an important role in an early step of WTA biosynthesis by providing an activated form of ManNAc. Identification of a selective MnaA...

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Veröffentlicht in:	Journal of biomolecular screening 2016-07, Vol.21 (6), p.579-589
Hauptverfasser:	Hou, Yan, Mayhood, Todd, Sheth, Payal, Tan, Christopher M., Labroli, Marc, Su, Jing, Wyss, Daniel F., Roemer, Terry, McCoy, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Lactam Resistance - drug effects beta-Lactamases - chemistry beta-Lactamases - drug effects Carbohydrate Epimerases - antagonists & inhibitors Carbohydrate Epimerases - chemistry Cell Wall - chemistry Cell Wall - drug effects Humans Magnetic Resonance Spectroscopy - methods Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - pathogenicity Teichoic Acids - chemistry Teichoic Acids - metabolism Uridine Diphosphate Sugars - chemistry Uridine Diphosphate Sugars - metabolism
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