Neuronal and Cardiovascular Potassium Channels as Therapeutic Drug Targets: Promise and Pitfalls

Potassium (K+) channels, with their diversity, often tissue-defined distribution, and critical role in controlling cellular excitability, have long held promise of being important drug targets for the treatment of dysrhythmias in the heart and abnormal neuronal activity within the brain. With the ex...

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Veröffentlicht in:	Journal of Biomolecular Screening 2015-10, Vol.20 (9), p.1055-1073
Hauptverfasser:	Humphries, Edward S. A., Dart, Caroline
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiovascular Agents - pharmacology Cardiovascular Agents - therapeutic use Cardiovascular Diseases - drug therapy Cardiovascular Diseases - metabolism Humans Myocardium - metabolism Nervous System Diseases - drug therapy Nervous System Diseases - metabolism Neurons - metabolism Potassium Channel Blockers - pharmacology Potassium Channel Blockers - therapeutic use Potassium Channels - physiology Review
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