A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation

Recent progress of genetic studies has dramatically unveiled pathogenesis of acute myeloid leukemia (AML). However, overall survival of AML still remains unsatisfactory, and development of novel therapeutics is required. CCAAT/enhancer binding protein α (C/EBPα) is one of the crucial transcription f...

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Veröffentlicht in:	Journal of biomolecular screening 2015-10, Vol.20 (9), p.1150-1159
Hauptverfasser:	Radomska, Hanna S., Jernigan, Finith, Nakayama, Sohei, Jorge, Susan E., Sun, Lijun, Tenen, Daniel G., Kobayashi, Susumu S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Base Sequence CCAAT-Enhancer-Binding Proteins - physiology Cell Differentiation - drug effects Drug Screening Assays, Antitumor Gene Expression Regulation, Leukemic - drug effects Genes, Reporter High-Throughput Screening Assays HL-60 Cells Humans Leukemia, Myeloid, Acute - drug therapy Transcriptional Activation - drug effects Tretinoin - pharmacology
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