Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression

Carboxyl-terminal binding protein (CtBP) is a transcriptional corepressor that suppresses multiple proapoptotic and epithelial genes. CtBP is overexpressed in many human cancers, and its overexpression increases stem cell–like features, epithelial-mesenchymal transition, and cancer cell survival. Kn...

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Veröffentlicht in:	Journal of biomolecular screening 2015-06, Vol.20 (5), p.663-672
Hauptverfasser:	Blevins, Melanie A., Kouznetsova, Jennifer, Krueger, Aaron B., King, Rebecca, Griner, Lesley Mathews, Hu, Xin, Southall, Noel, Marugan, Juan J., Zhang, Qinghong, Ferrer, Marc, Zhao, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - metabolism AlphaScreen Carrier Proteins - metabolism CtBP1 DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Drug Discovery - methods E1A Gene Expression Regulation - drug effects High-Throughput Screening Assays - methods Humans Naphthoquinones - pharmacology NSC95397 Protein Binding - drug effects protein-protein interaction Reproducibility of Results Small Molecule Libraries Substrate Specificity Transcription, Genetic - drug effects
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