Progesterone Receptor Chaperone Complex–Based High-Throughput Screening Assay: Identification of Capsaicin as an Inhibitor of the Hsp90 Machine

Hsp90 and its co-chaperones are known to be important for cancer cell survival. The N-terminal inhibitors of Hsp90 that are in ongoing clinical trials as antitumor agents have unfortunately shown disappointing efficacies in the clinic. Thus, novel inhibitors of the Hsp90 machine with a different mec...

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Veröffentlicht in:	Journal of biomolecular screening 2015-02, Vol.20 (2), p.223-229
Hauptverfasser:	Patwardhan, Chaitanya A., Alfa, Eyad, Lu, Su, Chadli, Ahmed
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Capsaicin - pharmacology Drug Discovery - methods Drug Screening Assays, Antitumor - methods High-Throughput Screening Assays - methods HSP90 Heat-Shock Proteins - antagonists & inhibitors Humans Molecular Chaperones - metabolism Protein Binding Receptors, Progesterone - antagonists & inhibitors Receptors, Progesterone - chemistry Receptors, Progesterone - metabolism Reproducibility of Results Small Molecule Libraries
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