Detection of Phospholipidosis Induction: A Cell-Based Assay in High-Throughput and High-Content Format

Drug-induced phospholipidosis is characterized by the accumulation of intracellular phospholipids in cells exposed to cationic amphiphilic drugs. The appearance of unicentric or multicentric multilamellar bodies viewed under an electron microscope (EM) is the morphological hallmark of phospholipidos...

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Veröffentlicht in:	Journal of biomolecular screening 2014-01, Vol.19 (1), p.66-76
Hauptverfasser:	Shahane, Sampada A., Huang, Ruili, Gerhold, David, Baxa, Ulrich, Austin, Christopher P., Xia, Menghang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiodarone Hep G2 Cells High-Throughput Screening Assays Humans Intracellular Space - metabolism Lipidoses - chemically induced Lipidoses - diagnosis Lipidoses - metabolism Microscopy, Electron, Transmission Phospholipids - metabolism Reproducibility of Results
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