A Phenotypic Screening Approach in Cord Blood–Derived Mast Cells to Identify Anti-Inflammatory Compounds

Mast cells are unique hematopoietic cells that are richly distributed in the skin and mucosal surfaces of the respiratory and gastrointestinal tract. They play a key role in allergic inflammation by releasing a cocktail of granular constituents, including histamine, serine proteases, and various eic...

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Veröffentlicht in:	Journal of biomolecular screening 2013-12, Vol.18 (10), p.1223-1233
Hauptverfasser:	Kaur, Rejbinder, Sloan, Lisa A., Blanchard, Andy D., Smith, Janet L., Churcher, Ian, Wayne, Gareth J., Ludbrook, Steven B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - pharmacology Biological Assay Cell Degranulation - drug effects Cells, Cultured Drug Evaluation, Preclinical - methods Fetal Blood - cytology Humans Inhibitory Concentration 50 Mast Cells - drug effects Mast Cells - metabolism Phenotype Prostaglandin D2 - metabolism Small Molecule Libraries
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