Biosensor-Expressing Spheroid Cultures for Imaging of Drug-Induced Effects in Three Dimensions

In the past, the majority of antitumor compound-screening approaches had been performed in two-dimensional (2D) cell cultures. Although easy to standardize, this method provides results of limited significance because cells are surrounded by an artificial microenvironment, are not exposed to hypoxia...

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Veröffentlicht in:	Journal of biomolecular screening 2013-07, Vol.18 (6), p.736-743
Hauptverfasser:	Wittig, Rainer, Richter, Verena, Wittig-Blaich, Stephanie, Weber, Petra, Strauss, Wolfgang S. L., Bruns, Thomas, Dick, Tobias P., Schneckenburger, Herbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Biosensing Techniques - methods Cell Culture Techniques - methods Cell Line, Tumor Drug Evaluation, Preclinical - methods Glioblastoma - drug therapy Glioblastoma - metabolism Glutathione - metabolism Green Fluorescent Proteins - metabolism Humans Hydrogen Peroxide - metabolism Imaging, Three-Dimensional - methods Microscopy - methods Oxidation-Reduction Spheroids, Cellular - drug effects
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