Use of Escin as a Perforating Agent on the IonWorks Quattro Automated Electrophysiology Platform

The automated electrophysiology platform IonWorks has facilitated the medium-throughput study of ion channel biology and pharmacology. Electrical and chemical access to the cell is by perforated patch, afforded by amphotericin. Permeation of the amphotericin pore is limited to monovalent cations. We...

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Veröffentlicht in:	Journal of biomolecular screening 2013-01, Vol.18 (1), p.128-134
Hauptverfasser:	Morton, Michael J., Main, Martin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B - pharmacology Animals Calcium Channel Blockers - pharmacology Calcium channels (voltage-gated) Calcium Channels, L-Type - metabolism Cations Channel pores CHO Cells Cricetinae Drug Evaluation, Preclinical - methods Drug Evaluation, Preclinical - standards Electrophysiology Escin - pharmacology HEK293 Cells Humans Ion channels Ionophores - pharmacology Lidocaine - analogs & derivatives Lidocaine - pharmacology Nucleotides Pharmacology Reference Standards Saponins
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