Screening, Identification, and Characterization of Mechanistically Diverse Inhibitors of the Mycobacterium Tuberculosis Enzyme, Pantothenate Kinase (CoaA)

The authors describe the discovery of anti-mycobacterial compounds through identifying mechanistically diverse inhibitors of the essential Mycobacterium tuberculosis (Mtb) enzyme, pantothenate kinase (CoaA). Target-driven drug discovery technologies often work with purified enzymes, and inhibitors t...

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Veröffentlicht in:	Journal of biomolecular screening 2012-03, Vol.17 (3), p.293-302
Hauptverfasser:	Venkatraman, Janani, Bhat, Jyothi, Solapure, Suresh M., Sandesh, Jatheendranath, Sarkar, Debasmita, Aishwarya, Sundaram, Mukherjee, Kakoli, Datta, Santanu, Malolanarasimhan, Krishnan, Bandodkar, Balachandra, Das, Kaveri S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Assay Drug Design Drug Evaluation, Preclinical Enzyme Inhibitors - analysis Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism High-Throughput Screening Assays - methods Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - enzymology Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors
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