Open Innovation for Phenotypic Drug Discovery: The PD2 Assay Panel

Phenotypic lead generation strategies seek to identify compounds that modulate complex, physiologically relevant systems, an approach that is complementary to traditional, target-directed strategies. Unlike gene-specific assays, phenotypic assays interrogate multiple molecular targets and signaling...

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Veröffentlicht in:	Journal of biomolecular screening 2011-07, Vol.16 (6), p.588-602
Hauptverfasser:	Lee, Jonathan A., Chu, Shaoyou, Willard, Francis S., Cox, Karen L., Sells Galvin, Rachelle J., Peery, Robert B., Oliver, Sarah E., Oler, Jennifer, Meredith, Tamika D., Heidler, Steven A., Gough, Wendy H., Husain, Saba, Palkowitz, Alan D., Moxham, Christopher M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - metabolism Cell Cycle - drug effects Cell Differentiation - drug effects Cell Line Drug Discovery Drug Evaluation, Preclinical HeLa Cells Humans Insulin - metabolism Insulin Secretion Mice Neovascularization, Physiologic - drug effects Nocodazole - pharmacology Osteoblasts - cytology Osteoblasts - metabolism Phenotype Protein Kinase Inhibitors - pharmacology Rats Reproducibility of Results Signal Transduction - drug effects Tubulin Modulators - pharmacology Wnt Proteins - metabolism
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