High-Throughput Screening for Small-Molecule Adiponectin Secretion Modulators

Adiponectin is an adipokine secreted by adipocytes and plays a role in the suppression of metabolic disorders that can result in type 2 diabetes, obesity, and atherosclerosis. Several studies have shown that upregulation of adiponectin has a number of therapeutic benefits. Although peroxisome prolif...

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Veröffentlicht in:	Journal of biomolecular screening 2011-07, Vol.16 (6), p.628-636
Hauptverfasser:	Hino, Kyosuke, Nagata, Hidetaka, Shimonishi, Manabu, Ido, Motoharu
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes - drug effects Adipocytes - metabolism Adiponectin - genetics Adiponectin - metabolism Animals Dose-Response Relationship, Drug High-Throughput Screening Assays Humans Mice NF-kappaB-Inducing Kinase Peroxisome Proliferator-Activated Receptors - genetics Promoter Regions, Genetic - genetics Protein Serine-Threonine Kinases - antagonists & inhibitors Regulatory Elements, Transcriptional - genetics Small Molecule Libraries - pharmacology
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