High-Throughput Fluorescence Assay for Small-Molecule Inhibitors of Autophagins/Atg4

Autophagy is an evolutionarily conserved process for catabolizing damaged proteins and organelles in a lysosome-dependent manner. Dysregulation of autophagy may cause various diseases, such as cancer and neurodegeneration. However, the relevance of autophagy to diseases remains controversial because...

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Veröffentlicht in:	Journal of biomolecular screening 2011-02, Vol.16 (2), p.174-182
Hauptverfasser:	Shu, Chih-Wen, Madiraju, Charitha, Zhai, Dayong, Welsh, Kate, Diaz, Paul, Sergienko, Eduard, Sano, Renata, Reed, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Autophagy-Related Proteins Caspase 3 - metabolism Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism Dose-Response Relationship, Drug Drug Evaluation, Preclinical Enzyme Inhibitors - metabolism Gene Order High-Throughput Screening Assays Humans Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Small Molecule Libraries Spectrometry, Fluorescence
Online-Zugang:	Volltext
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