Optimized High-Throughput Screen for Hepatitis C Virus Translation Inhibitors

Hepatitis C virus (HCV) is a considerable global health problem for which new classes of therapeutics are needed. The authors developed a high-throughput assay to identify compounds that selectively block translation initiation from the HCV internal ribosome entry site (HCV IRES). Rabbit reticulocyt...

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Veröffentlicht in:	Journal of biomolecular screening 2011-02, Vol.16 (2), p.211-220
Hauptverfasser:	Berry, Katherine E., Peng, Betty, Koditek, David, Beeman, Douglas, Pagratis, Nikos, Perry, Jason K., Parrish, Jay, Zhong, Weidong, Doudna, Jennifer A., Shih, I-hung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Evaluation, Preclinical Genes, Reporter Hepacivirus - genetics Hepacivirus - metabolism Hepatitis C virus High-Throughput Screening Assays Humans Protein Biosynthesis - drug effects Protein Biosynthesis - genetics Protein Synthesis Inhibitors - chemistry Protein Synthesis Inhibitors - pharmacology Puromycin - pharmacology Rabbits Reproducibility of Results Research Design RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Viral - genetics RNA, Viral - metabolism Small Molecule Libraries
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