Use of Cryopreserved Cells for Enabling Greater Flexibility in Compound Profiling

Measurement of intracellular calcium release following agonist challenge within cells expressing the relevant membrane protein is a commonly used format to derive structure-activity relationship (SAR) data within a compound profiling assay. The Fluorometric Imaging Plate Reader (FLIPR) has become th...

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Veröffentlicht in:	Journal of biomolecular screening 2008-06, Vol.13 (5), p.354-362
Hauptverfasser:	Wigglesworth, M.J., Lawless, K.J., Standing, D.J., Mackenzie, E.K., Kitchen, V.R., Mckay, F., Ward, E., Brough, S.J., Stylianou, M., Jewitt, F.R., Mclaren-Douglas, A.M., Jowet, M.I., Tamayama, N., Finnigan, D., Ding, J., Wise, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - analysis Calcium - metabolism Cells CHO Cells Cricetinae Cricetulus Cryopreservation Cryopreservation of organs, tissues, etc Drugs Fluorimetry Fluorometry - instrumentation Fluorometry - methods Histamine Humans Identification and classification Methods Physiological aspects Product/Service Evaluations Structure-Activity Relationship Structure-activity relationship (Pharmacology) Structure-activity relationships
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