Quantitative High-Throughput Screening Using a Live-Cell cAMP Assay Identifies Small-Molecule Agonists of the TSH Receptor

The thyroid-stimulating hormone (TSH; thyrotropin) receptor belongs to the glycoprotein hormone receptor subfamily of 7-transmembrane spanning receptors. TSH receptor (TSHR) is expressed mainly in thyroid follicular cells and is activated by TSH, which regulates the growth and function of thyroid fo...

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Veröffentlicht in:	Journal of biomolecular screening 2008-02, Vol.13 (2), p.120-127
Hauptverfasser:	Titus, Steve, Neumann, Susanne, Zheng, Wei, Southall, Noel, Michael, Sam, Klumpp, Carleen, Yasgar, Adam, Shinn, Paul, Thomas, Craig J., Inglese, James, Gershengorn, Marvin C., Austin, Christopher P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biological assay Biopsy Calibration Cells, Cultured CNG Cyclic AMP - analysis Drug Evaluation, Preclinical - methods False Positive Reactions HTS Humans Methods Miniaturization Models, Biological probe identification PubChem qHTS quantitative high-throughput screening Quantitative Structure-Activity Relationship Receptors, Thyrotropin - agonists Receptors, Thyrotropin - genetics Small Molecule Libraries - analysis Thyroid gland thyroid-stimulating hormone Thyrotropin Transfection TSH TSHR TSHR agonist
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