A Novel Platform for Accelerated Pharmacodynamic Profiling for Lead Optimization of Anticancer Drug Candidates

Oncology drug discovery is, by definition, a target-rich enterprise. High-throughput screening (HTS) laboratories have supported a wide array of molecularly targeted and chemical genomic approaches for anticancer lead generation, and the number of hits emerging from such campaigns has increased dram...

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Veröffentlicht in:	Journal of biomolecular screening 2007-03, Vol.12 (2), p.159-166
Hauptverfasser:	Szwaya, Jeffrey, Bruseo, Charles, Nakuci, Enkeleda, McSweeney, Denise, Xiang, Xiaoqin, Senator, David, France, Dennis, Chen, Chang-Rung
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimitotic agents Antineoplastic agents Antineoplastic Agents - analysis Antineoplastic Agents - pharmacology Blotting, Western Cancer Care and treatment Dose-Response Relationship, Drug Drug Design Electrophoresis, Polyacrylamide Gel Evaluation Studies as Topic HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - chemistry HSP90 Heat-Shock Proteins - genetics Humans Inhibitory Concentration 50 Kinetics Melanoma - drug therapy Neoplasms - drug therapy Oncology Pharmacology - instrumentation Pharmacology - methods Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - chemistry Proto-Oncogene Proteins B-raf - genetics Reference Values Reproducibility of Results Spectrophotometry, Infrared - methods Structure-Activity Relationship
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