A Novel Method for Analyzing [Ca2+] Flux Kinetics in High-Throughput Screening

Driven by multiparameter fluorescence readouts and the analysis of kinetic responses from biological assay systems, the amount and complexity of high-throughput screening data are constantly increasing. As a consequence, the reduction of data to a simple number, reflecting a percentage activity/inhi...

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Veröffentlicht in:	Journal of biomolecular screening 2006-08, Vol.11 (5), p.511-518
Hauptverfasser:	Gribbon, Philip, Chambers, Chris, Palo, Kaupo, Kupper, Juergen, Mueller, Juergen, Sewing, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological assay Calcium Calcium - metabolism Cells, Cultured Drug Evaluation, Preclinical - methods FLIPR Fluorometry - methods GPCR HTS Image Processing, Computer-Assisted - methods Ion Transport - drug effects Medical screening Models, Theoretical Pharmacokinetics Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - antagonists & inhibitors Time Factors
Online-Zugang:	Volltext
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