Simulation Modeling of Pooling for Combinatorial Protein Engineering

Pooling in directed-evolution experiments will greatly increase the throughput of screening systems, but important parameters such as the number of good mutants created and the activity level increase of the good mutants will depend highly on the protein being engineered. The authors developed and v...

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Veröffentlicht in:	Journal of biomolecular screening 2005-12, Vol.10 (8), p.856-864
Hauptverfasser:	Polizzi, Karen M., Spencer, Cody U., Dubey, Anshul, Matsumura, Ichiro, Lee, Jay H., Realff, Matthew J., Bommarius, Andreas S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Computer Simulation directed evolution Directed Molecular Evolution Drug Evaluation, Preclinical - methods Enzymes high-throughput screening Models, Biological Monte Carlo Method Monte Carlo simulation Protein Engineering Software Tissue Array Analysis
Online-Zugang:	Volltext
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