A Strategy for Discovery of Novel Broad-Spectrum Antibacterials Using a High-Throughput Streptococcus pneumoniae Transcription/Translation Screen

The authors report the development of a high-throughput screen for inhibitors of Streptococcus pneumoniae transcription and translation (TT) using a luciferase reporter, and the secondary assays used to determine the biochemical spectrum of activity and bacterial specificity. More than 220,000 compo...

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Veröffentlicht in:	Journal of biomolecular screening 2004-02, Vol.9 (1), p.3-11
Hauptverfasser:	Pratt, Steven D., David, Caroline A., Black-Schaefer, Candace, Dandliker, Peter J., Xuei, Xiaoling, Warrior, Usha, Burns, David J., Zhong, Ping, Cao, Zhensheng, Saiki, Anne Y. C., Lerner, Claude G., Chovan, Linda E., Soni, Niru B., Nilius, Angela M., Wagenaar, Frank L., Merta, Philip J., Traphagen, Linda M., Beutel, Bruce A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - pharmacology Base Sequence Cell Line, Tumor DNA, Bacterial Escherichia coli Genes, Reporter Humans Luciferases - genetics Microbial Sensitivity Tests - methods Molecular Sequence Data Protein Biosynthesis Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - genetics Transcription, Genetic
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